Abstract:
:The aims of this study are to determine the replacement rate of damaged hepatocytes by donor-derived cells in sex-mismatched recipient patients with thalassemia major and to determine whether co-transplantation of mesenchymal stem cells and hematopoietic stem cells (HSCs) can alleviate liver fibrosis. Ten sex-mismatched donor-recipient pairs who received co-transplantation of HSCs with mesenchymal stem cells were included in our study. Liver biopsy was performed before transplantation. Two other liver biopsies were performed between 2 and 5 years after transplantation. The specimens were studied for the presence of donor-derived epithelial cells or hepatocytes using fluorescence in situ hybridization by X- and Y-centromeric probes and immunohistochemical staining for pancytokeratin, CD45, and a hepatocyte-specific antigen. All sex-mismatched tissue samples demonstrated donor-derived hepatocyte independent of donor gender. XY-positive epithelial cells or hepatocytes accounted for 11 to 25% of the cells in histologic sections of female recipients in the first follow-up. It rose to 47-95% in the second follow-up. Although not statistically significant, four out of ten patients showed signs of improvement in liver fibrosis. Our results showed that co-transplantation of HSC with mesenchymal stem cells increases the rate of replacement of recipient hepatocytes by donor-derived cells and may improve liver fibrosis.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Ghavamzadeh A,Sotoudeh M,Hashemi Taheri AP,Alimoghaddam K,Pashaiefar H,Jalili M,Shahi F,Jahani M,Yaghmaie Mdoi
10.1007/s00277-017-3181-9subject
Has Abstractpub_date
2018-02-01 00:00:00pages
327-334issue
2eissn
0939-5555issn
1432-0584pii
10.1007/s00277-017-3181-9journal_volume
97pub_type
杂志文章abstract::A patient with painful peripheral neuropathy is presented, whose symptoms were thought to result from an infection with Borrelia burgdorferi sensu lato. Investigations of the cerebrospinal fluid for signs of inflammation and borrelial antibodies were negative, and the patient did not benefit from repeated antibiotic t...
journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章,meta分析
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01715373
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journal_title:Annals of hematology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF01697981
更新日期:1995-12-01 00:00:00
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journal_title:Annals of hematology
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doi:10.1007/s00277-011-1357-2
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-014-2289-4
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/BF01695972
更新日期:1993-06-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s00277-004-0952-x
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journal_title:Annals of hematology
pub_type: 杂志文章
doi:10.1007/s002770000196
更新日期:2000-10-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,评审
doi:10.1007/s002770050503
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journal_title:Annals of hematology
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更新日期:2005-02-01 00:00:00
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journal_title:Annals of hematology
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更新日期:1994-04-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
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更新日期:2011-09-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
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journal_title:Annals of hematology
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更新日期:2014-04-01 00:00:00
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journal_title:Annals of hematology
pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章
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journal_title:Annals of hematology
pub_type: 杂志文章
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