Abstract：
:Interferon alpha (IFN) inhibits the growth of the abnormal clone in patients with myeloproliferative disorders, leading to a reduction of the clinical and laboratory signs of the pathologic myeloproliferation. The therapeutic efficacy of IFN in polycythemia vera (PV) is demonstrated by the summarized treatment results of 279 patients participating in 16 prospective nonrandomized studies and in three case reports. The initial IFN dose ranged from 3 to 35 million IU/week. In 82% of the patients the frequency of phlebotomies was reduced. In 50% a complete remission was achieved, defined as a stable hematocrit of 45% without concomitant phlebotomies. Reduction of splenomegaly was seen in 77% and control of pruritus in 81% of the patients. The median observation time of the studies was 13 months (ranging from 3 to 84 months). Individual cases were followed for up to 126 months. In 21% of the patients IFN was terminated, owing mostly to side effects. The selective suppression of the malignant clone by IFN was demonstrated by the induction of cytogenetic remissions in sporadic cases with a chromosomal marker and by the observation of unmaintained remissions that lasted up to 4.8 years. IFN has no known mutagenic or teratogenic effects. The data presently available demonstrate that IFN is an effective alternative to the present forms of treatment in PV. Controlled prospective studies are essential to clarify whether the favorable biologic properties are also reflected by a benefit in clinical course and survival, and whether IFN may reduce the rates of acute leukemia and myelofibrosis. A randomized study that compares IFN and hydroxyurea in patients with PV has recently been initiated by the Suddeutsche Hamoblastosegruppe (SHG) in Germany.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Lengfelder E,Berger U,Hehlmann Rdoi
10.1007/s002770050563subject
Has Abstractpub_date
2000-03-01 00:00:00pages
103-9issue
3eissn
0939-5555issn
1432-0584journal_volume
79pub_type
杂志文章,评审abstract：:Reactivation of fetal hemoglobin synthesis in adulthood can be seen in hematological disorders affecting the erythropoietic system. The objective of the present study was to evaluate the incidence and prognostic significance of increased hemoglobin F in patients with myelodysplastic syndrome. Hemoglobin F concentratio...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050377
更新日期：1998-03-01 00:00:00
abstract：:Chronic idiopathic neutropenia (CIN) has been well recognized as a granulocytic disorder not associated with increased risk to malignant transformation. Four cases, however, of acute myeloid leukemia have been recently reported in patients with CIN. In the current paper, we report on a CIN patient who developed acute ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-004-0862-y
更新日期：2004-06-01 00:00:00
abstract：:Multicentric Castleman's disease (MCD) is a rare systemic lymphoproliferative disorder with too few patient series reported in the literature to have a clear idea about the etiology, outcome and the best treatment available. Systemic reactive amyloidosis is a very rare complication of MCD and its presence worsens the ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0718-x
更新日期：2003-12-01 00:00:00
abstract：:We integrated molecular data with available prognostic factors in patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) for myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (sAML) from MDS to evaluate their impact on prognosis. Three hundred four patients were sequenced for muta...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-017-3027-5
更新日期：2017-08-01 00:00:00
abstract：:Delayed platelet engraftment (DPE) is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). This phenomenon is also a predictor of increased treatment-related mortality and poor survival. Therefore, therapies that promote platelet engraftment to prevent DPE are needed. This pr...
journal_title：Annals of hematology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00277-014-2158-1
更新日期：2015-01-01 00:00:00
abstract：:We conducted a phase 2 study with bortezomib, doxorubicin, and dexamethasone (PAD) followed by thalidomide and dexamethasone (TD) in patients with relapsed multiple myeloma (MM). Forty patients were enrolled between November 2005 and October 2007, with follow-up continuing until January 2009. Efficacy could be assesse...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-010-0943-z
更新日期：2010-09-01 00:00:00
abstract：:The clarification of enlarged lymph nodes is a common issue in clinical routine. By now, open surgery with complete lymph node extirpation, followed by histopathology, is considered as standard. We investigated the value of fine needle aspiration (FNA) and core needle biopsy (CNB) when supporting the conventional morp...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-012-1476-4
更新日期：2012-09-01 00:00:00
abstract：:Photodynamic virus inactivation of human fresh plasma mediated by visible light in the presence of the phenothiazine dyes methylene blue or toluidine blue was investigated to determine whether it influences functional, structural, and immunological properties of plasma proteins. The activities of the coagulation facto...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01703949
更新日期：1992-11-01 00:00:00
abstract：:An acute leukemia with an unusual immunophenotype developed in a 17-year-old girl. At the initial presentation, extramedullary involvement was not evident, but with advancing disease, massive splenomegaly and an osteolytic rib tumor developed. The disease was aggressive and refractory to intensive chemotherapeutic reg...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050472
更新日期：1999-01-01 00:00:00
abstract：:Although eosinophilia has been reported as a side effect of purine analogues, there is no report on fludarabine-induced eosinophilia in chronic lymphocytic leukemia (CLL). During chemotherapy with fludarabine and cyclophosphamide, we observed two cases of significant eosinophilia. A 67-year-old patient with CLL develo...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s002770050602
更新日期：1999-10-01 00:00:00
abstract：:Parenteral human immunoglobulin (IVIG) administration is widely used in low birth weight (LBW) infants for prevention and therapy of neonatal infection. In previous studies, IVIG preparations containing IgG and low IgM concentrations were commonly used. In this study we compare immunoglobulin serum levels in two group...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01703445
更新日期：1991-10-01 00:00:00
abstract：:The aim of this study was to analyze the ability of an alloantibody from a patient with severe von Willebrand disease (vWD) to interfere with the vWF domain for FVIII, to inhibit factor VIII (FVIII), and to compare it with a rabbit polyclonal antibody. The vWF domain for binding to FVIII was assayed by a method previo...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050323
更新日期：1997-09-01 00:00:00
abstract：:We recently reported that IgM antibody-related microparticles exist in some patients with idiopathic thrombocytopenic purpura (ITP) [14]. In this study, we investigated the relationship between antiphospholipid (cardiolipin and phosphatidylinositol) antibodies and microparticles in 56 ITP patients. We used an ELISA to...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01715126
更新日期：1992-07-01 00:00:00
abstract：:Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-2943-8
更新日期：2017-05-01 00:00:00
abstract：:Acute leukemia (AL) patients may experience more than one episode of bloodstream infection (BSI) caused by the same pathogen during the entire chemotherapy program. In order to identify factors influencing BSI recurrence (R-BSI) during subsequent phases of treatment, we analyzed all BSIs occurring to consecutively tre...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1965-0
更新日期：2014-05-01 00:00:00
abstract：:Primary non-Hodgkin's lymphoma of bone (PLB) is a rare entity. We present three new cases and a review of the literature. If PLB is suspected radiologically, the diagnosis must be confirmed by open biopsy. Histopathologically, PLB usually represents diffuse large B-cell lymphoma or lymphoma of the follicular center ty...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-003-0674-5
更新日期：2003-07-01 00:00:00
abstract：:As ethnic variations are known to exist in inherited genetic defects, the clinico-haematological profile of Indian children with thrombophilia may be different from that of Caucasians. The aim of the study was to analyse the phenotypic and genotypic causes of thrombophilia in Indian children. Forty patients with arter...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-004-0952-x
更新日期：2005-02-01 00:00:00
abstract：:Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is an atypical lympho-proliferative disorder with borderline features that often constitute a diagnostic challenge for the hematopathologist and a therapeutic dilemma for the treating clinician. Morphologically, the involved lymph nodes in this disorder are...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050244
更新日期：1996-12-01 00:00:00
abstract：:Polycythemias or erythrocytoses in childhood and adolescence are very rare. Systematic data on the clinical presentation and laboratory evaluations as well as on treatment regimens are sparse. The diagnostic program in absolute erythrocytosis includes extensive clinical, hematological, biochemical, and molecular biolo...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-004-0985-1
更新日期：2005-03-01 00:00:00
abstract：:Treatment of acute lymphoblastic leukemia (ALL) requires the combination of multiple drugs to integrate a complete remission. The different prognostic factors (age, leukocytes, risk, cytogenetic alterations) allow identifying those patients with a high risk of relapse, but there are few described factors that impact t...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-04277-y
更新日期：2020-11-01 00:00:00
abstract：:A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal a...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0795-x
更新日期：2004-06-01 00:00:00
abstract：:A 40-year-old patient with low-grade B-NHL developed a generalized macular-papular rash following the first cycle of fludarabine treatment which progressed to a complete epidermal necrolysis following the second cycle. Clinical symptoms and the results of the direct and indirect immunofluorescence were consistent with...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050347
更新日期：1997-11-01 00:00:00
abstract：:The absence of researches about autophagy in multiple myeloma promoted us to explore the biological characteristics and role of autophagy induced by nutrient depletion in multiple myeloma (MM) cell line RPMI8226 cells. Both autophagic and apoptotic morphology were observed by TUNEL, transmission electron microscopy (T...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1315-z
更新日期：2012-03-01 00:00:00
abstract：:Blastic transformation of essential thrombocythemia (ET) preceded by chemotherapy is occasionally described in the literature. In ET as well as in other myeloproliferative disorders the leukemogenic effect of alkylating agents and (32)P is well established, and recent reports also indicate a certain leukemogenic effec...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050007
更新日期：2000-01-01 00:00:00
abstract：:In a large proportion of patients with mild bleeding disorders (MBDs) no diagnosis can be established by routine coagulation tests. We investigated whether alterations in plasma clot properties account for MBDs of unknown cause. Ninety-five patients with MBDs of unknown origin and 98 age- and sex-matched healthy contr...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-015-2399-7
更新日期：2015-08-01 00:00:00
abstract：:An additional affiliation for the first author was not indicated. Hyewon Lee is also affiliated with: Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, South Korea. ...
journal_title：Annals of hematology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00277-019-03868-8
更新日期：2020-01-01 00:00:00
abstract：:Organizing pneumonia (OP) is a poorly understood complication of hematopoietic stem cell transplant (HSCT). We identified 15 patients diagnosed with OP following HSCT and described their clinical course. CT chest findings were remarkable for multifocal infiltrates that were predominantly consolidating or ground glass ...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03746-3
更新日期：2019-09-01 00:00:00
abstract：:In Germany, analyses of clinical and laboratory features of patients with acute porphyrias are only available for hereditary coproporphyria (HCP) but not with other acute porphyrias, acute intermittent porphyria (AIP) and variegate porphyria (VP). The aim of the study was to analyze a large cohort of patients with par...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-019-03831-7
更新日期：2019-12-01 00:00:00
abstract：:Primary non-Hodgkin's lymphoma (NHL) of the genital tract is a rare entity. Etiology and pathogenesis of these NHLs are unknown, although there might be a possible association between chronic inflammation and lymphomas. The most common histological subtype is the diffuse large B-cell lymphoma. We report two cases of u...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-009-0741-7
更新日期：2009-12-01 00:00:00
abstract：:We aimed to evaluate the treatments, particularly the role of corticosteroids, in patients with late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). One hundred and sixty-three consecutive patients who underwent non-T-cell-depleted allo-HSCT and met the criterion...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-018-3290-0
更新日期：2018-07-01 00:00:00
