The predictive value of selected serum microRNAs for acute GVHD by TaqMan MicroRNA arrays.

abstract：:In vitro studies suggest that haploinsufficiency is involved in the pathogenesis of myelodysplastic syndromes (MDS). In patients with del5q cytogenetic abnormality, RPS-14 and microRNAs (miRNAs) play a major role. In a multicenter phase II single-arm trial with lenalidomide in anemic primary del5q MDS patients with lo...

journal_title：Annals of hematology

authors： Oliva EN,Cuzzola M,Aloe Spiriti MA,Poloni A,Laganà C,Rigolino C,Morabito F,Galimberti S,Ghio R,Cortelezzi A,Palumbo GA,Sanpaolo G,Finelli C,Ricco A,Volpe A,Rodà F,Breccia M,Alimena G,Nobile F,Latagliata R

更新日期：2013-01-01 00:00:00

abstract：:In some instances, because of the lack of mass formation and the absence of prominent lymph node enlargement, diagnosis of lymphoma-associated hemophagocytic syndrome (LAHS) is difficult, which results in the development of progressive disease with unfavorable prognosis. Therefore, in the diagnosis of secondary hemoph...

journal_title：Annals of hematology

authors： Tabata C,Tabata R

更新日期：2012-01-01 00:00:00

abstract：:We report on a patient who was diagnosed as having B-cell chronic lymphocytic leukemia (CLL) with atypical morphology. Flow cytometry disclosed CD5, CD19, and CD23 positivity, an immunophenotype seen mostly in B-CLL. Histology of the spleen and bone marrow suggested a diagnosis of small lymphocytic lymphoma. Upon blas...

journal_title：Annals of hematology

authors： Späth-Schwalbe E,Flath B,Kaufmann O,Thiel G,Brinckmann R,Dietel M,Possinger K

更新日期：2000-04-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets accompanied by an increased risk of bleeding, which can have a significant negative impact on patients' health-related quality of life. The condition has long been associated with an increased rate of immune-mediated plat...

journal_title：Annals of hematology

authors： Kühne T,Imbach P

更新日期：2010-07-01 00:00:00

abstract：:Recently, it was shown that glycoproteins with N-glycans close to the NH(2) terminus can directly enter the calnexin/calreticulin cycle and bypass BiP binding. This should allow efficient secretion of glycoproteins such as factor VIII (FVIII) whose secretion is negatively affected by BiP interaction. Examination of th...

journal_title：Annals of hematology

authors： Srour MA,Grupp J,Aburubaiha Z,Albert T,Brondke H,Oldenburg J,Schwaab R

更新日期：2008-02-01 00:00:00

abstract：:Assay of phosphotyrosine levels using flow cytometry has been used to identify patients with chronic myelogenous leukemia positive for the Bcr-Abl fusion gene. We hypothesized that clinical monitoring could identify treatment response through reductions in intragranulocyte phosphotyrosine. Initially, we studied cell l...

journal_title：Annals of hematology

authors： Sun X,Li J,Chen J,Li D,Chen L,Xu W,Yang Y,Wu Y,Jiang P,Xie W

更新日期：2009-01-01 00:00:00

abstract：:Interferon alpha (IFN) inhibits the growth of the abnormal clone in patients with myeloproliferative disorders, leading to a reduction of the clinical and laboratory signs of the pathologic myeloproliferation. The therapeutic efficacy of IFN in polycythemia vera (PV) is demonstrated by the summarized treatment results...

journal_title：Annals of hematology

authors： Lengfelder E,Berger U,Hehlmann R

更新日期：2000-03-01 00:00:00

abstract：:We conducted a nationwide cohort study of adult Danish patients with primary chronic immune thrombocytopenia (cITP) to examine selected patient and clinical characteristics as predictors for splenectomy. We analyzed data from the Danish National Patient Registry and patient medical records from 1996 to 2007. Using Cox...

journal_title：Annals of hematology

authors： Jensen AO,Nørgaard M,Engebjerg MC,Farkas DK,Fryzek JP,Zhao S,Sørensen HT

更新日期：2011-02-01 00:00:00

abstract：:Recently, the combination of rituximab and bendamustine (R-Benda) has been defined as highly active in patients with follicular lymphomas, but little is known about the efficacy of R-Benda in mucosa-associated lymphoid tissue (MALT) lymphoma. In a retrospective analysis, we have defined 14 patients with MALT lymphoma ...

journal_title：Annals of hematology

authors： Kiesewetter B,Mayerhoefer ME,Lukas J,Zielinski CC,Müllauer L,Raderer M

更新日期：2014-02-01 00:00:00

abstract：:Acute Epstein-Barr virus (EBV) infection commonly induces hematological abnormalities, most notably atypical lymphocytosis ("infectious mononucleosis"). In addition, mild decreases in platelet counts are commonly encountered in uncomplicated cases; however, severe thrombocytopenia is exceedingly rare. Here, we describ...

journal_title：Annals of hematology

authors： Walter RB,Hong TC,Bachli EB

更新日期：2002-11-01 00:00:00

abstract：:This study aimed to systematically review the prognostic value of interim and end-of-treatment (18)F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in follicular lymphoma during and after first-line therapy. The PubMed/MEDLINE database was searched for relevant original studies. Included studies were ...

journal_title：Annals of hematology

authors： Adams HJA,Nievelstein RAJ,Kwee TC

更新日期：2016-01-01 00:00:00

abstract：:We report the case of a 23-year-old female with severe neurologic dysfunction without a clear cause at the time of initial presentation. The search for an underlying malignancy revealed a slightly enlarged cervical lymph node with Hodgkin's disease (HD). There was no evidence of a brain tumor despite nonspecific brigh...

journal_title：Annals of hematology

authors： Kalinka E,Robak T,Wrzesien-Kus A,Krykowski E,Warzocha K

更新日期：2002-05-01 00:00:00

abstract：:Patients with Philadelphia chromosome-positive (Ph+) and/or BCR-ABL+ acute lymphoblastic leukemia (ALL) have extremely poor prognoses. Most of these patients have additional, heterogenous karyotype abnormalities, the majority of which have uncertain clinical significance. In this study we analyzed the clinical charact...

journal_title：Annals of hematology

authors： Wrzesień-Kuś A,Robak T,Pluta A,Zwolińska M,Wawrzyniak E,Wierzbowska A,Skotnicki A,Jakubas B,Hołowiecki J,Nowak K,Kuliczkowski K,Mazur G,Haus O,Dmoszyńska A,Adamczyk-Cioch M,Jedrzejczak WW,Paluszewska M,Konopka L,Pałyn

更新日期：2006-06-01 00:00:00

abstract：:This retrospective single-center analysis studied the impact of the conditioning and the graft-versus-host disease (GVHD) prophylaxis on outcome in unselected patients allografted for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) secondary to documented prior CMML. A total of 44 patients (med...

journal_title：Annals of hematology

authors： Radujkovic A,Hegenbart U,Müller-Tidow C,Herfarth K,Dreger P,Luft T

更新日期：2020-04-01 00:00:00

abstract：:Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where ...

journal_title：Annals of hematology

authors： Jud S,Goede JS,Senn O,Spanaus K,Manz MG,Benz R

更新日期：2017-05-01 00:00:00

abstract：:The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities of H. pylori eradication ...

journal_title：Annals of hematology

authors： Kim H,Lee WS,Lee KH,Bae SH,Kim MK,Joo YD,Zang DY,Jo JC,Lee SM,Lee JH,Lee JH,Kim DY,Ryoo HM,Hyun MS,Kim HJ,CoOperative Study Group A for Hematology (COSAH).

更新日期：2015-05-01 00:00:00

abstract：:We retrospectively analyzed very early chimerism before and ongoing neutrophil engraftment (days 7, 14, 21, 28) and investigated the influence of conditioning regimens and stem cell sources on donor-type chimerism in 59 Japanese patients who had received allogeneic hematopoietic stem cell transplantation. The percenta...

journal_title：Annals of hematology

authors： Sugita J,Tanaka J,Hashimoto A,Shiratori S,Yasumoto A,Wakasa K,Kikuchi M,Shigematsu A,Miura Y,Tsutsumi Y,Kondo T,Asaka M,Imamura M

更新日期：2008-12-01 00:00:00

abstract：:Standard conditioning for allogeneic bone marrow transplantation induces high transplant-related mortality (TRM) in patients with a poor performance status. Less intensive regimens have been tested to reduce the TRM; our purpose was to evaluate the feasibility and tolerability of a new combination: thiotepa and fludar...

journal_title：Annals of hematology

authors： Alessandrino EP,Bernasconi P,Colombo AA,Caldera D,Bonfichi M,Pagnucco G,Malcovati L,Varettoni M,Lazzarino M,Bernasconi C

更新日期：2001-09-01 00:00:00

abstract：:This study retrospectively analyzed the clinical outcome of 172 children with newly diagnosed severe aplastic anemia (SAA) between January 2008 and April 2018, who received rabbit antithymocyte globulin (ATG) and cyclosporine (CsA) as first-line treatment. The median age at diagnosis was 5 years (range, 1-14). The ove...

journal_title：Annals of hematology

authors： Lan Y,Chang L,Yi M,Cai Y,Feng J,Ren Y,Liu C,Chen X,Wang S,Guo Y,Zhang A,Liu L,Zhang J,Zhu X

更新日期：2021-01-01 00:00:00

abstract：:Two immunocompetent patients with cat-scratch disease due to infection with Bartonella henselae developed monoclonal and biclonal gammopathy. Neither patient had evidence of any other known cause of plasma cell dyscrasia, and antibiotic eradication of Bartonella henselae infection resulted in the prompt disappearance ...

journal_title：Annals of hematology

authors： Krause R,Auner HW,Daxböck F,Mulabecirovic A,Krejs GJ,Wenisch C,Reisinger EC

更新日期：2003-07-01 00:00:00

abstract：:The requirement of antifungal prophylaxis has not been established in the chemotherapies for malignant lymphoma. This study was conducted to explore the incidence of invasive fungal diseases (IFD) and their risk factors in patients receiving salvage therapies for malignant lymphoma. We retrospectively analyzed 177 con...

journal_title：Annals of hematology

authors： Takaoka K,Nannya Y,Shinohara A,Arai S,Nakamura F,Kurokawa M

更新日期：2014-10-01 00:00:00

abstract：:Thirty-nine pregnant women with idiopathic thrombocytopenic purpura (ITP) were studied in order to evaluate the influence of therapies for maternal ITP on fetal passive immune thrombocytopenia (PIT). Neonatal platelet counts were also compared with platelet counts, amount of PAIgG, and presence of circulating antiplat...

journal_title：Annals of hematology

authors： Yamada H,Fujimoto S

更新日期：1994-01-01 00:00:00

abstract：:We tested two Fc gamma receptor I (Fc gamma RI); six Fc gamma RII; and six Fc gamma RIII-specific monoclonal antibodies (mAb) for their capacity to inhibit monocyte and polymorphonuclear granulocyte (PMN) immune phagocytosis which is mediated by Fc gamma R. We used human red blood cells (rbc) coated with hIgG1 or mIgG...

journal_title：Annals of hematology

authors： Flesch BK,Achtert G,Neppert J

更新日期：1997-01-01 00:00:00

abstract：:The general impact of blood donation on iron status was studied in a population survey comprising 1359 nonpregnant Danish women in age cohorts of 30, 40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal; 180 (13%) were blood donors. Iron stores were assessed by serum (S)-ferritin and hemoglobin (Hb). Hb...

journal_title：Annals of hematology

authors： Milman N,Kirchhoff M

更新日期：1991-07-01 00:00:00

abstract：PURPOSE:To determine whether, after very intensive induction and consolidation therapy in childhood AML, further maintenance therapy (MT) confers any advantage. PATIENTS AND METHODS:Three hundred-nine children with previously untreated AML were registered in the LAME 89/91 protocol. This three-cycle intensive regimen ...

journal_title：Annals of hematology

authors： Perel Y,Auvrignon A,Leblanc T,Michel G,Vannier JP,Dalle JH,Gandemer V,Schmitt C,Mèchinaud F,Lamagnere JP,Piguet Ch,Couillaud G,Pautard B,Baruchel A,Leverger G,Group LAME.,French Society of Pediatric Hematology and Immunol

更新日期：2004-01-01 00:00:00

abstract：:MicroRNAs are short noncoding RNAs, known regulators of several signaling pathways cell differentiation and proliferation, development, and apoptosis, which are deregulated in acute leukemia. Mixed lineage leukemia (MLL) gene encodes a protein with histone methyltransferase activity, which is essential for the fine tu...

journal_title：Annals of hematology

authors： Benetatos L,Vartholomatos G

更新日期：2013-11-01 00:00:00

abstract：:The object of this study was to assess the estimation of 2- and 5-year overall survival and tumor response and the frequency and severity of treatment morbidity with a modified ProMACE-MOPP hybrid protocol in patients with primary CNS lymphoma (PCNSL). Thirty-two immunocompetent patients were treated with a regimen of...

journal_title：Annals of hematology

authors： Yamanaka R,Morii K,Shinbo Y,Takeuchi S,Tamura T,Hondoh H,Takahashi H,Onda K,Takahashi H,Tanaka R

更新日期：2005-07-01 00:00:00

abstract：:FLT3 and its ligand (FL) are one of the regulators of normal hematopoiesis. Ligand-independent activation of FLT3 occurs in about 30% of acute myeloid leukemia cases and is one goal for selectively targeted therapies. However, the function of FLT3/FL in the regulation of non-malignant immature hematopoietic cells is p...

journal_title：Annals of hematology

authors： Weisel KC,Yildirim S,Schweikle E,Kanz L,Möhle R

更新日期：2009-03-01 00:00:00

abstract：:Genes involved in the hemostatic mechanism are logical candidate genes for association studies in prothrombotic conditions such as stroke. Since the underlying etiology in pediatric strokes is different than adults, looking for genetic causes would be the logical thing to do in the pediatric stroke population. Fifty-e...

journal_title：Annals of hematology

authors： Biswas A,Tiwari AK,Ranjan R,Meena A,Akhter MS,Yadav BK,Behari M,Saxena R

更新日期：2009-05-01 00:00:00

abstract：:To elucidate the role of hematopoietic growth factors (HGFs) and other cytokines in the autocrine or paracrine regulation of inducible hematopoiesis we studied cytokine gene expression in the bone marrow (BM) of patients after myelosuppressive treatment. Furthermore, we studied the cytokine gene expression profile in ...

journal_title：Annals of hematology

authors： Cluitmans FH,Esendam BH,Veenhof WF,Landegent JE,Willemze R,Falkenburg JH

更新日期：1997-07-01 00:00:00