Abstract：
:To examine the mechanism of HIV-1 regulation by NF-IL6 in activated human cells, we selected a Jurkat cell line that did not contain endogenous NF-IL6. In this cellular environment, we evaluated the effect of exogenous NF-IL6 on transcription mediated by native and deleted LTR sequences. In Jurkat cells stimulated with LPS and PMA, LTR-mediated transcription was enhanced by NF-IL6. The results of deletion studies revealed a central role for the basal LTR region and the TATA element in the LTR, in upregulation of reporter gene expression by NF-IL6 in activated cells. In the selected cellular environment, regulation of transcription by NF-IL6 was not evident in studies of promoter regions of other genes. The results implied that the basal region of HIV-1 LTR includes molecular properties that support activation of HIV-1 by NF-IL6 in stimulated cells.
journal_name
Virus Resjournal_title
Virus researchauthors
Buckner AE,Tesmer VM,Bina Mdoi
10.1016/s0168-1702(02)00110-7subject
Has Abstractpub_date
2002-10-01 00:00:00pages
53-63issue
1eissn
0168-1702issn
1872-7492pii
S0168170202001107journal_volume
89pub_type
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