Abstract:
:Signaling by TGFbeta regulates the expression of hundreds of genes. The rapid repression of c-Myc stands out because of its roles in growth control and cancer. Recent work shows that c-Myc repression by TGFbeta is mediated by the nuclear translocation of a novel, preformed complex composed of Smad3, E2F4 or E2F5, and the Rb-related factor p107.
journal_name
Mol Celljournal_title
Molecular cellauthors
Kowalik TFdoi
10.1016/s1097-2765(02)00584-1subject
Has Abstractpub_date
2002-07-01 00:00:00pages
7-8issue
1eissn
1097-2765issn
1097-4164pii
S1097-2765(02)00584-1journal_volume
10pub_type
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