Abstract：
:Prions constitute a rare class of protein, which can switch to a robust amyloid form and then propagate that form in the absence of a nucleic acid determinant, thereby creating a unique, protein-only infectious agent. Details of the mechanism that drives conversion to the prion form and then subsequent propagation of that form are beginning to emerge using a range of in vivo and in vitro approaches. Recent studies on both mammalian and fungal prions are providing a greater understanding of the structural features that distinguish prions from non-transmissible amyloids.
journal_name
Mol Celljournal_title
Molecular cellauthors
Tuite MF,Koloteva-Levin Ndoi
10.1016/j.molcel.2004.05.012subject
Has Abstractpub_date
2004-06-04 00:00:00pages
541-52issue
5eissn
1097-2765issn
1097-4164pii
S1097-2765(04)00298-9journal_volume
14pub_type
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