Abstract:
:In filamentous ascomycetes, glucose repression is mediated by CRE1, a zinc-finger protein related to Miglp from yeast. Five putative AMPK phosphorylation motifs identified in the glucose repressor from the phytopathogenic fungus Sclerotinia sclerotiorum were mutated in a GFP::CRE1 translational fusion. Complementation experiments in Aspergillus nidulans and fluorescence microscopy analyses showed that mutation of one site (Ser266) abolishes the repressor activity of the fusion protein but not its nuclear targeting, suggesting that an AMPK protein kinase may be involved in the function of the fungal glucose repressor.
journal_name
Curr Genetjournal_title
Current geneticsauthors
Vautard-Mey G,Fèvre Mdoi
10.1007/s002940050535subject
Has Abstractpub_date
2000-05-01 00:00:00pages
328-32issue
5eissn
0172-8083issn
1432-0983journal_volume
37pub_type
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