Angiographic and pathological studies on regression of coronary atherosclerosis of FH patients who received LDL-apheresis treatment.

Abstract:

:We report on the most recent data confirming the angiographic and pathological efficacy of LDL-apheresis for coronary atherosclerosis of a familial hypercholesterolemia (FH) patient using collected data of a large number of cases and especially of one autopsy case. Changes in coronary artery stenosis have been assessed angiographically in 37 FH patients in the LDL-Apheresis Regression Study (LARS) group of 13 institutions in Japan. Definite regression was observed in 21 segments by visual and computer analysis. Fourteen of 37 patients (37.8%) who had received LDL-apheresis treatment in combination with cholesterol-lowering drugs had at least one regressed segment without any progressed segment. We pathologically examined at autopsy the coronary arteries in one FH patient who had received long-term LDL-apheresis therapy before death. The results revealed the process of scarring of atheromatous plaque, suggesting pathological regression correlated with the angiographic regression shown in serial angiograms taken during LDL-apheresis treatment. It was further suggested that the formation of an eccentric thickened wall lesion rich in collagen fiber prevented atheromatous plaque from tearing off. Such tearing off might lead to an acute coronary event. Aggressive cholesterol-lowering therapy based on LDL-apheresis can induce both angiographic and pathological regression in coronary atherosclerosis of FH patients.

journal_name

Artif Organs

journal_title

Artificial organs

authors

Koga N,Iwata Y,Yamamoto A

doi

10.1111/j.1525-1594.1992.tb00289.x

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

171-6

issue

2

eissn

0160-564X

issn

1525-1594

journal_volume

16

pub_type

杂志文章
  • Outcomes with ventricular assist device versus extracorporeal membrane oxygenation as a bridge to pediatric heart transplantation.

    abstract::Extracorporeal membrane oxygenation (ECMO) has long been the sole means of mechanical support for pediatric patients with end-stage cardiac failure, but has a high waitlist mortality and a reported survival to hospital discharge of less than 50%. The purpose of this study was to compare waitlist mortality and survival...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00969.x

    authors: Jeewa A,Manlhiot C,McCrindle BW,Van Arsdell G,Humpl T,Dipchand AI

    更新日期:2010-12-01 00:00:00

  • Systemic consequences of ventricular assist devices: alterations of coagulation, immune function, inflammation, and the neuroendocrine system.

    abstract::Implantable ventricular assist devices have proven efficacious as a bridge to transplantation and as a bridge to recovery. Although current indications for use of assist devices are somewhat limited, they are likely to expand in the upcoming years, including their use as destination therapy for end-stage heart failure...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1046/j.1525-1594.2002.07122.x

    authors: Hampton CR,Verrier ED

    更新日期:2002-11-01 00:00:00

  • Assessment of skeletal muscle ventricle tissue blood flow using positron emission tomography.

    abstract::In this pilot study, we assessed the feasibility of using positron emission tomography (PET) imaging for in vivo measurement of skeletal muscle ventricle (SMV) tissue blood flow. In 4 dogs, with SMVs prepared from their latissimus dorsi muscle, we quantified SMV tissue blood flow by PET and related it to the tissue fl...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:

    authors: Singh TP,Greer K,Muzik O,Hammond RL,Stephenson LW,Di Carli MF

    更新日期:2001-04-01 00:00:00

  • Estimation of theophylline clearance during continuous arteriovenous hemofiltration.

    abstract::Pharmacologic agents and other non-protein-bound compounds smaller than 5,000 daltons have the potential to be removed by continuous arteriovenous hemofiltration (CAVH). A proposed method for estimating drug clearance by CAVH (ClCAVH) equates ultrafiltrate clearance to the product of the sieving coefficient and the av...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1990.tb02997.x

    authors: Horton MW,Godley PJ,Moore ES,Fineg J,Gillespie WR

    更新日期:1990-12-01 00:00:00

  • Techniques for optimization of pulsatile ventricular assist device support.

    abstract::For some time now researchers have argued the efficacy of pulsatile versus nonpulsatile hemodynamic support. Pulsatile systems, while providing a more physiological pumping source, are burdened with a multiparametric output function that can greatly affect the utility of such ventricular assist device (VAD) support. A...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00299.x

    authors: Mills TC,Ott RA

    更新日期:1992-04-01 00:00:00

  • Oral treatment for jaundice using immobilized bilirubin oxidase.

    abstract::Jaundice is characterized by an excessive accumulation of bilirubin in the blood and tissues. A novel approach to reduce plasma levels of bilirubin by blocking its enterohepatic circulation was investigated. The treatment consisted of oral administration of immobilized bilirubin oxidase, which could oxidize bilirubin ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1992.tb00527.x

    authors: Soltys PJ,Mullon C,Langer R

    更新日期:1992-08-01 00:00:00

  • A nonsurgical technique for blood access in extracorporeal affinity adsorption of antibodies in rats.

    abstract::Monoclonal antibodies for targeting cytotoxic conjugates to tumor cells are currently being evaluated together with extracorporeal affinity adsorption. The aim of the adsorption was to reduce undesired side effects in normal organs and to increase the tumor-to-normal tissue ratios. This technique is also applicable to...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00380.x

    authors: Mårtensson L,Nilsson R,Sjögren HO,Strand SE,Tennvall J

    更新日期:2007-04-01 00:00:00

  • Effect of cyclosporine therapy with low doses of corticosteroids on idiopathic nephrotic syndrome.

    abstract::Cyclosporine (CyA) has an immunosuppressive effect that might suggest a therapeutic role in idiopathic glomerular conditions. We focused on the optimization of CyA treatment control in patients with idiopathic nephrotic syndrome by using trough-level CyA measurements (C0) and the 2-h postdose levels (C2). Twenty-two p...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2009.00838.x

    authors: Griveas I,Visvardis G,Papadopoulou D,Nakopolou L,Karanikas E,Gogos K,Stavianoudakis G

    更新日期:2010-03-01 00:00:00

  • In vivo characterization of a decellularized dermis-polymer complex for use in percutaneous devices.

    abstract::To develop a method for making percutaneous devices that have high biocompatibility and do not induce downgrowth of epidermal cells, we prepared a partial decellularized dermis (DD)/poly(methyl methacrylate) (PMMA) complex (PDPC) with a PMMA rod firmly stabilized inside. The porcine decellularized tissue was chosen be...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12330

    authors: Nam K,Matsushima R,Kimura T,Fujisato T,Kishida A

    更新日期:2014-12-01 00:00:00

  • Circulatory support for patients experiencing postcardiotomy cardiogenic shock: analysis of risk factors for death and long-term follow-up.

    abstract::Over the last 5 years, 12 patients received ventricular assist devices (VADs) while in postcardiotomy cardiogenic shock. There were 7 male and 5 female patients ranging in age from 22 to 73 years (average age, 54). Eight patients underwent surgery for valve replacements, 3 for coronary artery bypass graftings, and 1 f...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1993.tb00608.x

    authors: Murakami T,Nakayama H,Irie H,Kino K,Hisamochi K,Koomoto T,Takagaki M,Sugawara E,Senoo Y,Teramoto S

    更新日期:1993-07-01 00:00:00

  • Acceleration of peritoneal mass transport by drugs and hormones.

    abstract::The major restrictions to the transport of solute and solvent across the peritoneum are the limited peritoneal blood flow, area and permeability. Recent investigations have demonstrated that several vasoactive drugs influence transport parameters. Isoproterenol, nitroprusside, dipyridamole and dopamine exemplify drugs...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1979.tb01052.x

    authors: Maher JF

    更新日期:1979-08-01 00:00:00

  • Superior mesenteric artery mycotic aneurysm in patients with left ventricular assist device support and intravenous drug abuse.

    abstract::Mycotic aneurysm of the superior mesenteric artery (SMA) is one of the complications associated with infective endocarditis. However, there are no previous case reports in the literature describing mycotic SMA aneurysm after left ventricular assist device (LVAD) implantation. We describe the case of a 31-year-old male...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2011.01250.x

    authors: Motomura T,Bruckner B,Leon-Becerril J,Anaya-Ayala JE,de Rienzo-Madero B,Bismuth J,Bunge R,Irwin S,Loebe M

    更新日期:2011-07-01 00:00:00

  • Glucose-insulin kinetics of a bioartificial pancreas made of an AN69 hydrogel hollow fiber containing porcine islets and implanted in diabetic mice.

    abstract::The goal of this study was to determine whether porcine islets encapsulated in hollow fibers made of AN69 copolymer can correct hyperglycemia in diabetic mice and provide normal tolerance to a glucose challenge. In vitro perifusion of hollow fibers demonstrated the rapid kinetics of insulin release in response to gluc...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1998.05087.x

    authors: Delaunay C,Darquy S,Honiger J,Capron F,Rouault C,Reach G

    更新日期:1998-04-01 00:00:00

  • Blood transfusion in pediatric cardiac surgery.

    abstract::The aim of the study is to measure the volume of homologous blood needed for one pediatric patient during his hospital stay. Over a 4-month period, all the patients operated upon with a blood prime or requiring blood transfusion during their hospital stay were included in this study.The cardiopulmonary bypass protocol...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2010.01158.x

    authors: Durandy Y

    更新日期:2010-11-01 00:00:00

  • A newly designed adapter for testing an ex vivo mitral valve apparatus.

    abstract::Few instruments are currently available to test mitral valve function in an ex vivo state due to the technical difficulties involved. To investigate the native ex vivo mitral valve or prosthetic mitral valve with chordae, we developed a mitral valve adapter with an annulus suturing portion and 2 papillary muscle sutur...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06293.x

    authors: Katoh T,Ikeda N,Nishi K,Gohra H,Hamano K,Noda H,Fujimura Y,Esato K

    更新日期:1999-10-01 00:00:00

  • Influence of flow design on microcirculation in conditions of undulation pump-left ventricle assist device testing.

    abstract::To study the microvessels in bulbar conjunctiva, we conducted an experiment in goat with a pneumatically driven left heart bypass pump, which was replaced with an undulation pump-left ventricle assist device for 9 days. Three flow patterns were tested: complete pulsatile, continuous, and percentage of pulsatile. We st...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2006.00244.x

    authors: Dobsák P,Novakova M,Baba A,Vasku J,Isoyama T,Saito I,Abe Y,Chinzei T,Imachi K

    更新日期:2006-06-01 00:00:00

  • Electrochemical and Electrophysiological Performance of Platinum Electrodes Within the Ninety-Nine-Electrode Stimulating Nerve Cuff.

    abstract::The trend in neural prostheses using selective nerve stimulation for electrical stimulation therapies is headed toward single-part systems having a large number of working electrodes (WEs), each of which selectively stimulate neural tissue or record neural response (NR). The present article reviews the electrochemical...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审

    doi:10.1111/aor.12625

    authors: Pečlin P,Mehle A,Karpe B,Rozman J

    更新日期:2015-10-01 00:00:00

  • Experimental study on shear stress distributions in a centrifugal blood pump.

    abstract::Wall shear stress on the pump casing cover was measured using a surface-mounted hot-film sensor. In addition, the shear stress distribution in the pump was qualitatively investigated by means of oil-film visualization. The characteristics of shear stress in the pump are discussed, including the results on the oil-film...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.2007.00421.x

    authors: Mizunuma H,Nakajima R

    更新日期:2007-07-01 00:00:00

  • Paper is a compatible bed for rat hepatocytes.

    abstract::To develop an effective hybrid bioartificial liver (BAL) device, the material of the scaffold is very important to support hepatocytes that have both growth ability and hepatic differentiated functions. In this study we used paper (Kimwipe, Kimberly-Clark Corp., Roswell, GA, U.S.A.) as a scaffold. Primary hepatocytes ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2000.06506.x

    authors: Mizuguchi T,Mitaka T,Sato F,Mochizuki Y,Hirata K

    更新日期:2000-04-01 00:00:00

  • Myristoyl gelatin as a sealant for Dacron vascular prostheses.

    abstract::Myristoyl gelatin (MG) retains its gel structure at temperatures above body temperature without any crosslinking. As a coating material, MG adheres well to polyester fibers, and the outermost layers of the sealant that are in contact with blood or surrounding tissue become hydrophilic. We produced MG-impregnated knitt...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1997.tb00363.x

    authors: Sasajima T,Inaba M,Azuma N,Goh K,Koshiko S,Kubo Y,Miyamoto K,Tokita M,Komai T

    更新日期:1997-04-01 00:00:00

  • Acellular Endocardium as a Novel Biomaterial for the Intima of Tissue-Engineered Small-Caliber Vascular Grafts.

    abstract::We aimed to investigate whether acellular endocardium can be used as a useful biomaterial for the intima of engineered small-caliber vascular grafts. Fresh endocardium was harvested from the swine left atrium and was decellularized by digestion with the decellularization solution of Triton X-100 and SDS containing DNa...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12814

    authors: Wang F,Guan X,Wu T,Qiao J,Han Z,Wu J,Yu X,You Q

    更新日期:2016-12-01 00:00:00

  • Can We Develop a Nonpulsatile Permanent Rotary Blood Pump? Yes, We Can.

    abstract::For many years, it was thought that nonpulsatile perfusion produced physiological and circulatory abnormalities. Since 1977, Yukihiko Nosé and his colleagues have challenged this misconception. Toward that end, they did show that if a 20% higher blood flow uses more than that required for a pulsatile blood pump, then ...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1996.tb04466.x

    authors: Nosé Y,Kawahito K,Nakazawa T

    更新日期:1996-05-01 00:00:00

  • An implantable two channel drop foot stimulator: initial clinical results.

    abstract::This article reports preliminary results of pilot studies of a new implantable two channel drop foot stimulator. The stimulator consists of an externally worn transmitter inductively coupled to an implanted receiver unit located in the lower leg, lateral and distal to the knee. The receiver is connected to electrodes ...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1525-1594.2002.06949.x

    authors: Kenney L,Bultstra G,Buschman R,Taylor P,Mann G,Hermens H,Holsheimer J,Nene A,Tenniglo M,van der Aa H,Hobby J

    更新日期:2002-03-01 00:00:00

  • Correlation between cerebral-renal near-infrared spectroscopy and ipsilateral renal perfusion parameters as clinical outcome predictors after open heart surgery in neonates and infants.

    abstract::The objective of this clinical study is to determine whether correlation exists among cerebral and renal near-infrared spectroscopy (NIRS) measurements, renal Doppler ultrasonography parameters (resistive index, peak systolic velocity), and early postoperative clinical outcomes following cardiac surgery in neonates an...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/aor.12455

    authors: Örmeci T,Alkan-Bozkaya T,Özyüksel A,Ersoy C,Ündar A,Akçevin A,Türkoğlu H

    更新日期:2015-01-01 00:00:00

  • Uremic neuropathy: evidence of middle molecule toxicity.

    abstract::Ten dialysis patients were followed in a prospective study to determine the neurotoxicity of metabolites in the middle molecule (MM) molecular weight (mol wt) range of 500-200 daltons/molecule. In the absence of readily available direct serum measurements of MM concentrations, a theoretically calculated dialysis index...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1978.tb01002.x

    authors: Milutinovic J,Babb AL,Eschbach JW,Follette WC,Graefe U,Strand MJ,Scribner BH

    更新日期:1978-02-01 00:00:00

  • Clinical validation of a predictive modeling equation for sodium.

    abstract::Changes in plasma sodium (Na) concentration during hemodialysis were predicted by changes in Na concentration of the dialysate at equilibrium with the plasma, according to the formula C't = CD - (CD - C'0) [(V0 - QFt)/V0]A/QF, where C'0 and C't are the Na concentration of the dialysate at equilibrium with the plasma a...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04365.x

    authors: Man NK,Petitclerc T,Tien NQ,Jehenne G,Funck-Brentano JL

    更新日期:1985-05-01 00:00:00

  • Artificial liver: present and future.

    abstract::Early in 1956, the first model of a biological artificial liver, using a live dog's liver incorporated in a cross-hemodialyzer, was placed in an experimental animal with portocaval encephalopathy. This "biological artificial liver," a hybrid artificial liver in the present terminology, was the first in the world. In O...

    journal_title:Artificial organs

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1525-1594.1986.tb02548.x

    authors: Hori M

    更新日期:1986-06-01 00:00:00

  • Chaotic dynamics in circulation with Tohoku University vibrating flow pump.

    abstract::For the development of a totally implantable ventricular assist system (VAS), we have been developing the vibrating flow pump (VFP), which can generate oscillated blood flow with a relative high frequency (10-50 Hz) for a totally implantable system. In this study, the effects of left ventricular assistance with this u...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.1999.06288.x

    authors: Nitta S,Yambe T,Kobayashi S,Hashimoto H,Yoshizawa M,Mastuki H,Tabayashi K,Takeda H

    更新日期:1999-01-01 00:00:00

  • Extracorporeal membrane oxygenator compatible with centrifugal blood pumps.

    abstract::Coil-type silicone membrane oxygenators can only be used with roller blood pumps due to the resistance from the high blood flow. Therefore, during extracorporeal membrane oxygenation (ECMO) treatment, the combination of a roller pump and an oxygenator with a high blood flow resistance will induce severe hemolysis, whi...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1046/j.1525-1594.2002.07117.x

    authors: Motomura T,Maeda T,Kawahito S,Matsui T,Ichikawa S,Ishitoya H,Kawamura M,Nishimura I,Shinohara T,Oestmann D,Glueck J,Kawaguchi Y,Sato K,Nosé Y

    更新日期:2002-11-01 00:00:00

  • Utilization of activated carbon hemoperfusion to assist recovery of ischemically damaged canine liver allografts.

    abstract::The sensitivity of liver allografts to even minimal periods of ischemia currently limits the duration of hepatic preservation prior to liver transplantation. This study evaluates the role of activated carbon hemoperfusion (ACH) for assisting the recovery of canine livers ischemically damaged by a 20-min occlusion of t...

    journal_title:Artificial organs

    pub_type: 杂志文章

    doi:10.1111/j.1525-1594.1985.tb04386.x

    authors: Toledo-Pereyra LH

    更新日期:1985-08-01 00:00:00