当前位置： SCI文献检索 > NUCLEAR MEDICINE AND BIOLOGY期刊下所有文献 > New bis(dithiocarboxylato) nitridotechnetium-99m radiopharmaceuticals for leucocyte labelling: in vitro and in vivo studies.

New bis(dithiocarboxylato) nitridotechnetium-99m radiopharmaceuticals for leucocyte labelling: in vitro and in vivo studies.

Abstract：

:Dithiocarboxylate ligands were synthesized and characterised. New nitrido 99m-technetium complexes were obtained with these ligands and identified by thin layer chromatography. The nitrido complexes were tested in vitro in whole blood for leucocyte labelling and the design of the ligand was optimized. Best results were obtained with aliphatic linear ligands, containing 9 to 11 atoms of carbon. The in vivo experiment failed because an inflammated area could not be visualized by gamma imaging, the cell labelling mechanism being probably different.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Demaimay F,Noiret N,Roucoux A,Patin H,Bellande E,Pasqualini R,Moisan A

doi

10.1016/s0969-8051(97)00025-5

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

439-45

issue

5

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(97)80012-1

journal_volume

24

pub_type

杂志文章

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