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Dual radiolabeled liposomes: biodistribution studies and localization of focal sites of infection in rats.

Abstract：

:Liposomes encapsulating both glutathione and deferoxamine were labeled with 99mTc-HMPAO and 111In-oxine at the same time. These dual radiolabeled liposomes were intravenously injected in rats with S. aureus infection in thigh. The target-to-background ratio (T/BG) increased from 2.9 at 2 h to 4.4 at 8 h in 99mTc images. In 111In images, T/BG of 5.5 at 8 h increased to 10.5 by 48 h. The 24-h spleen uptake of 111In- and 99mTc-liposomes was 24.14%ID and 8.91%ID. In femur, 99mTc-liposomes remained at approximately 10.5%ID, but 111In-liposomes increased from approximately 11%ID at 4 h to approximately 25.5%ID at 24 h. The simultaneous presence of 99mTc and 111In in the liposomes resulted in good early (2-8 h) as well as delayed (24-48 h) images delineating the infection site.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Awasthi VD,Goins B,Klipper R,Phillips WT

doi

10.1016/s0969-8051(97)00162-5

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

155-60

issue

2

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(97)00162-5

journal_volume

25

pub_type

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