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Rhodium-105 tetrathioether complexes: radiochemistry and initial biological evaluation.

Abstract：

:105Rhodium(III) complexes with three different acyclic tetrathioether ligands containing pendant carboxylic acid groups have been synthesized and characterized. The complexes were evaluated for stability under physiological conditions and the most promising complexes were evaluated in vivo in normal mice. The primary route of clearance for these complexes was the renal/urinary system, consistent with the presence of pendant carboxylate groups. The results indicate that the cis-[Rh(III)Cl2(2,5,8,11-tetrathiadodecane-1,12-dicarboxylic acid)]+ complex shows the most promising in vivo characteristics on which to base a potential therapeutic radiopharmaceutical.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Goswami N,Higginbotham C,Volkert W,Alberto R,Nef W,Jurisson S

doi

10.1016/s0969-8051(99)00070-0

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

951-7

issue

8

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(99)00070-0

journal_volume

26

pub_type

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