Synthesis and properties of 18F-labeled potential myocardial blood flow tracers.

abstract：:The herpes simplex virus type 1 thymidine kinase (HSV1-TK) reporter system is being used to directly and indirectly monitor therapeutic gene expression, immune cell trafficking and protein-protein interactions in various living animals. However, the issues of HSV1-TK enzyme stability in living cells and whether this r...

journal_title：Nuclear medicine and biology

authors： Hsieh CH,Liu RS,Wang HE,Hwang JJ,Deng WP,Chen JC,Chen FD

更新日期：2006-07-01 00:00:00

abstract：INTRODUCTION:Earlier studies indicated that bevacizumab could favorably be combined with radiation. However excessive damage to tumor vasculature can result in radioresistance and clinical data suggest that treatment sequencing may be important when combining bevacizumab with radiation. The aim of this study was to eva...

journal_title：Nuclear medicine and biology

authors： Becker S,Bohn P,Bouyeure-Petit AC,Modzelewski R,Gensanne D,Picquenot JM,Dubray B,Vera P

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:(99m)Tc-MDP (technetium-99(m)-labeled methylene diphosphonate) has been widely used as a radiopharmaceutical for bone scintigraphy in cases of metastatic bone disease. (177)Lu is presently considered as an excellent radionuclide for developing bone pain palliation agents. No study on preparing a complex of (1...

journal_title：Nuclear medicine and biology

authors： Abbasi IA

更新日期：2011-04-01 00:00:00

abstract：:The premise that, over the course of Alzheimer's disease (AD), changes in the levels of the vesicular acetylcholine transporter (VAChT) occur in parallel with changes to other cholinergic marker proteins provides the basis for the applicability of benzovesamicol derivatives as radioligands for AD studies by single pho...

journal_title：Nuclear medicine and biology

authors： Emond P,Mavel S,Zea-Ponce Y,Kassiou M,Garreau L,Bodard S,Drossard ML,Chalon S,Guilloteau D

更新日期：2007-11-01 00:00:00

abstract：:Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. [(166)Dy]Dy/(166)Ho-ethylenediaminetetramethylene phosphonate (EDTMP) forms a stable in vivo generator system with selective skeletal uptake in mice; therefore, i...

journal_title：Nuclear medicine and biology

authors： Pedraza-López M,Ferro-Flores G,Arteaga de Murphy C,Morales-Ramírez P,Piedras-Ross J,Murphy-Stack E,Hernández-Oviedo O

更新日期：2004-11-01 00:00:00

abstract：INTRODUCTION:The utility of [(18)F]FPBM [2-(2'-((dimethylamino)methyl)-4'-(3-[(18)F]-fluoropropoxy)phenylthio)benzenamine], a selective serotonin transporter (SERT) tracer, and [(18)F]AV-133 [(+)-2-Hydroxy-3-isobutyl-9-(3-fluoropropoxy)-10-methoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine], a selective vesicular m...

journal_title：Nuclear medicine and biology

authors： Wang JL,Oya S,Parhi AK,Lieberman BP,Ploessl K,Hou C,Kung HF

更新日期：2010-05-01 00:00:00

abstract：INTRODUCTION:Radiolabeled gastrin analogs represent attractive candidates for diagnosis and therapy of cholecystokinin subtype-2 receptor (CCK2R)-expressing tumors. Radiolabeled des(Glu)5-gastrins show favorably low renal accumulation, but localize poorly in CCK2R-positive lesions. We introduce herein three truncated [...

journal_title：Nuclear medicine and biology

authors： Kaloudi A,Nock BA,Lymperis E,Sallegger W,Krenning EP,de Jong M,Maina T

更新日期：2015-11-01 00:00:00

abstract：:6-Hydrazinopyridine-3-carboxylic acid (HYNIC) is a representative agent used to prepare technetium-99m ((99m)Tc)-labeled polypeptides with tricine as a coligand. However, (99m)Tc-HYNIC-labeled polypeptides show delayed elimination rates of the radioactivity not only from the blood but also from nontarget tissues such ...

journal_title：Nuclear medicine and biology

authors： Ono M,Arano Y,Mukai T,Fujioka Y,Ogawa K,Uehara T,Saga T,Konishi J,Saji H

更新日期：2001-04-01 00:00:00

abstract：:The aim of this study was to assess the biological behavior of new radiolabeled glucose analogues proposed as tracers of glucose uptake in vivo and iodinated in position 3, 4, or 6. Biological results obtained in vitro on adipocytes and erythrocytes and in vivo in mice were compared to those obtained with the gold-sta...

journal_title：Nuclear medicine and biology

authors： Perret P,Ghezzi C,Ogier L,Abbadi M,Morin C,Mathieu JP,Fagret D

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:The in vitro and in vivo behavior of the radiolabeled monoclonal antibody MORAb-003 was investigated as a prelude to a clinical trial. METHODS:The cellular retention of 111In- and 131I-labeled MORAb-003 was investigated using IGROV1 and SW620 cells. Biodistribution studies in tumor-bearing mice were perfo...

journal_title：Nuclear medicine and biology

authors： Smith-Jones PM,Pandit-Taskar N,Cao W,O'Donoghue J,Philips MD,Carrasquillo J,Konner JA,Old LJ,Larson SM

更新日期：2008-04-01 00:00:00

abstract：:Quantitative imaging of glucose metabolism of human brain tumors with PET utilizes 2-[(18)F]-fluorodeoxy-D-glucose (FDG) and a conversion factor called the lumped constant (LC), which relates the metabolic rate of FDG to glucose. Since tumors have greater uptake of FDG than would be predicted by the metabolism of nati...

journal_title：Nuclear medicine and biology

authors： Muzi M,Freeman SD,Burrows RC,Wiseman RW,Link JM,Krohn KA,Graham MM,Spence AM

更新日期：2001-02-01 00:00:00

abstract：:The aim of this work was to develop a method to produce 18F-labeled fluorine gas ([18F]F2) with high specific radioactivity (SA, radioactivity/mass-ratio). 18F-Labeled methyl fluoride ([18F]CH3F) was synthesized from [18F]F-aq and mixed with carrier F2 in an inert neon matrix. The constituents were atomized in an elec...

journal_title：Nuclear medicine and biology

authors： Bergman J,Solin O

更新日期：1997-10-01 00:00:00

abstract：INTRODUCTION:Thymidylate synthase and folate receptors are well-developed targets of cancer therapy. Discovery of a simple and fast method for the conversion of 11CH3Ito[11C]-formaldehyde (11CH2O) encouraged us to label the co-factor of this enzyme. Preliminary studies conducted on cell lines have demonstrated a prefer...

journal_title：Nuclear medicine and biology

authors： Saeed M,Tewson TJ,Erdahl CE,Kohen A

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:We synthesized and evaluated (64)Cu-labeled tetraiodothyroacetic acid (tetrac)-conjugated liposomes for PET imaging of tumor angiogenesis, because tetrac inhibits angiogenesis via integrin αVβ3. METHODS:Tetrac-PEG-DSPE and DOTA-PEG-DSPE were synthesized and formulated with other lipids into liposomes. The...

journal_title：Nuclear medicine and biology

authors： Kang CM,Koo HJ,Lee S,Lee KC,Oh YK,Choe YS

更新日期：2013-11-01 00:00:00

abstract：:HeLa S-3 cells were treated with 195mPt-radiolabeled trans-diaminedichloroplatinum(II) (TDDP) under various conditions, and the relationship between lethal effect and the number of Pt atoms binding to DNA, RNA and proteins was examined. The mean lethal concentrations for the cells treated with TDDP at 37 degrees C for...

journal_title：Nuclear medicine and biology

authors： Akaboshi M,Kawai K,Maki H,Akuta K,Ujeno Y,Ono K,Miyahara T

更新日期：1993-05-01 00:00:00

abstract：:We examined transport of 3-[(125)I]iodo-alpha-methyl-L-tyrosine ([(125)I]IMT) in Xenopus laevis oocytes co-expressing human L-type amino acid transporter 1 (a component of system L) and human 4F2hc. Human LAT1 mediated transport of [(125)I]IMT. [(125)I]IMT uptake was decreased by the presence of L-isomers of Cys, Leu,...

journal_title：Nuclear medicine and biology

authors： Shikano N,Kanai Y,Kawai K,Ishikawa N,Endou H

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Fatty acid amide hydrolase (FAAH) is the enzyme responsible for metabolising the endogenous cannabinoid, anandamide, and thus represents an important target for molecular imaging. To date, no radiotracer has been shown to be useful for imaging of FAAH using either positron emission tomography (PET) or sing...

journal_title：Nuclear medicine and biology

authors： Wilson AA,Garcia A,Parkes J,Houle S,Tong J,Vasdev N

更新日期：2011-02-01 00:00:00

abstract：:With [11C]raclopride,[11C]nemonapride and [11C]N-methylspiperone, degeneration of dopamine D2-like receptors in the unilaterally quinolinic acid-lesioned rats was evaluated by positron emission tomography (PET) and ex vivo and in vitro autoradiography. PET showed a decreased uptake of [11C]raclopride in the lesioned s...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Ogi N,Hayakawa N,Umegaki H,Nagaoka T,Oda K,Toyama H,Endo K,Tanaka A,Senda M

更新日期：2002-04-01 00:00:00

abstract：:We attempted to measure the regional metabolic rate of glucose (MRglc) in sliced spinal cords in vitro. The thoracic spinal cord of a mature Wister rat was cut into 400-mum slices in oxygenated and cooled (1-4 degrees C) Krebs-Ringer solution. After at least 60 min of preincubation, the spinal cord slices were transfe...

journal_title：Nuclear medicine and biology

authors： Fan X,Asai T,Morioka K,Uchida K,Baba H,Tanaka K,Zhuang J,Okazawa H,Fujibayashi Y

更新日期：2009-02-01 00:00:00

abstract：INTRODUCTION:High expression of the system L amino acid transporter has been observed in clinically important tissues including tumors and the blood-brain barrier. We examined amino acid transport system L selectivity of (14)C(U)-L-tyrosine ((14)C-Tyr), (125)I-4-iodo-L-meta-tyrosine (4-(125)I-mTyr), (125)I-6-iodo-L-met...

journal_title：Nuclear medicine and biology

authors： Shikano N,Kotani T,Nakajima S,Ogura M,Nakazawa S,Sagara J,Kobayashi M,Baba T,Yamaguchi N,Kubota N,Kawai K

更新日期：2010-11-01 00:00:00

abstract：:We have investigated whether [186Re]-labeled chimeric monoclonal antibody 323/A3 (MAb c-323/A3) is as effective as [186Re]-labeled mouse 323/A3 (m-323/A3) in the growth inhibition of human ovarian cancer xenografts OVCAR-3 and FMa. [186Re] was conjugated to MAbs with the use of the chelate S-benzoylmercaptoacetyltrigl...

journal_title：Nuclear medicine and biology

authors： Kievit E,van Gog FB,Schlüper HM,van Dongen GA,Pinedo HM,Boven E

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:Renal uptake of Tc-99m-MG3 involves organic anion transporter (OAT). Treatment with drugs showing OAT affinity might interfere with renal uptake of Tc-99m-MAG3, leading to misinterpretation in Tc-99m-MAG3. This study was conducted to discuss a possible drug interference with Tc-99m-MAG3 diagnosis on OAT si...

journal_title：Nuclear medicine and biology

authors： Takahara N,Saga T,Inubushi M,Kusuhara H,Seki C,Ito S,Oyama N,Yokoyama O,Sugiyama Y,Fujibayashi Y

更新日期：2013-07-01 00:00:00

abstract：:By variation of reaction parameters iodination of 3-(9,10-didehydro-6-methyl-8 alpha-ergolinyl)-1,1-diethylurea (lisuride) was performed with the radiohalogen [123I]iodine (t1/2 = 13.3 h). For comparative experiments and stability studies the beta(-)-emitting radioisotope [131I]iodine (t1/2 = 8.04 d) was also used. Re...

journal_title：Nuclear medicine and biology

authors： Bier D,Dutschka K,Knust EJ

更新日期：1996-04-01 00:00:00

abstract：:Conjugates of For-MLFK and For-NleLFNleYK with S-benzyl mercaptoacetyl dipeptides containing, respectively, zero, one, and two carboxyl functions in their structures were prepared and labeled with (99m)Tc. In vitro binding studies using isolated human granulocytes indicated specific receptor binding of the radiolabele...

journal_title：Nuclear medicine and biology

authors： Verbeke K,Snauwaert K,Cleynhens B,Scheers W,Verbruggen A

更新日期：2000-11-01 00:00:00

abstract：:In the quantitative studies of presynaptic dopamine metabolism by PET with 6-[18F]fluoro-L-dopa (6-[18F]FDOPA), metabolic analysis in the plasma is required to determine the precise input function because of susceptibility of the compound to peripheral metabolism. In this study, we prepared 6-[18F]-fluoro-O-pivaloyl-L...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Shinoda M,Ishii S,Nozaki T,Senda M

更新日期：1996-04-01 00:00:00

abstract：:We present a method for estimating 99mTc-MAG3 clearance from both a single injection and two blood samples that is valid for both adults and children. It was obtained by fitting a scaled two-compartment model (having only two adjustable parameters) to adult and pediatric data from multiple centers. ...

journal_title：Nuclear medicine and biology

authors： Russell CD,Taylor AT Jr,Dubovsky EV,Eshima D

更新日期：1995-01-01 00:00:00

abstract：:In the past 10 years, significant progress has been made in using a technetium-99m dopamine transporter imaging agent, [99mTc]TRODAT, for routine clinical studies. Developing a molecular imaging agent from bench to the bedside is more than a simple scientific venture. Currently, Taiwan is the only place where [99mTc]T...

journal_title：Nuclear medicine and biology

authors： Kung HF,Kung MP,Wey SP,Lin KJ,Yen TC

更新日期：2007-10-01 00:00:00

abstract：:Metabolic studies of (111)In-DTPA-labeled polypeptides and peptides showed that the radiolabeled (poly)peptides generated (111)In-DTPA-adducts of amino acid that possess long residence times in the lysosomal compartment of the tissues where (poly)peptides accumulated. However, a recent study suggested that metal-chela...

journal_title：Nuclear medicine and biology

authors： Akizawa H,Arano Y,Mifune M,Iwado A,Saito Y,Uehara T,Ono M,Fujioka Y,Ogawa K,Kiso Y,Saji H

更新日期：2001-05-01 00:00:00

abstract：INTRODUCTION:This paper proposes liposomes as a potential new tool for radioimmunotherapy in solid tumours with a two step targeting system. Tumour pretargeting is obtained by using a monoclonal bispecific antibody (BsmAb, anti CEA x anti-DTPA-In) and pegylated liposomes containing lipid-hapten (DSPE-DTPA-In or DSPE-PE...

journal_title：Nuclear medicine and biology

authors： Rauscher A,Frindel M,Maurel C,Maillasson M,Le Saëc P,Rajerison H,Gestin JF,Barbet J,Faivre-Chauvet A,Mougin-Degraef M

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the effectiveness of PET in differentiating malignant from benign pancreatic cystic tumors. METHODS:Between 2009 and 2010, all patients with pancreatic cystic tumors who had PET, triple phase contrast computed tomography (CT) and endoscopic ultrasound (EUS) were reviewed. Clinicopathological cha...

journal_title：Nuclear medicine and biology

authors： Zhang Y,Frampton AE,Martin JL,Kyriakides C,Bong JJ,Habib NA,Vlavianos P,Jiao LR

更新日期：2012-10-01 00:00:00