[186Re]-labeled mouse and chimeric monoclonal antibody 323/A3: a comparison of the efficacy in experimental human ovarian cancer.

abstract：INTRODUCTION:Amino acid based radiotracers target tumor cells through increased uptake by membrane-associated amino acid transport (AAT) systems. In the present study, four structurally related non-natural (18)F-labeled amino acids, (R)- and (S)-[(18)F]FAMP 1 and (R)- and (S)-[(18)F]MeFAMP 2 have been prepared and eval...

journal_title：Nuclear medicine and biology

authors： Yu W,McConathy J,Olson JJ,Goodman MM

更新日期：2015-01-01 00:00:00

abstract：:The uptake of 65Zn, determined by gamma-counting and also by autoradiography, significantly increased with the increasing level of metallothionein in liver 4 weeks after the start of feeding a diet containing 3'-methyl-dimethylaminoazobenzene (3'-Me-DAB), at which time the serum gamma-glutamyl transpeptidase activity ...

journal_title：Nuclear medicine and biology

authors： Takeda A,Tamano H,Ohnuma M,Okada S

更新日期：1995-04-01 00:00:00

abstract：:Packed capillary liquid chromatography with electrospray mass spectrometry was used for direct determination of the specific radioactivity by calculation of isotope ratios between the (76)Br- and (79)Br-labeled analogues of N-((3-aminomethyl)benzyl)-4-bromobenzamide. Using 20 microL injections on packed capillary colu...

journal_title：Nuclear medicine and biology

authors： Forngren BH,Yngve U,Forngren T,Långström B

更新日期：2000-11-01 00:00:00

abstract：:Central benzodiazepine receptor binding was studied in spontaneously epileptic rats (SER) and in their parent strain. Kyoto-Wistar (KW) rats, by ex vivo quantitative autoradiography with [125I]iomazenil. Thirteen-week-old SER developed tonic and absence-like seizures following mild stimulation by tapping at 5 min befo...

journal_title：Nuclear medicine and biology

authors： Nagata T,Saji H,Nishizawa S,Yonekura Y,Yamamoto I,Iida Y,Magata Y,Konishi J,Serikawa T,Yokoyama A

更新日期：1995-05-01 00:00:00

abstract：:Porcine insulin was labeled with 99mTc by direct tin reduction. More than 95% labeling efficiency was obtained on paper chromatography in saline and methyl ethyl ketone. The stability of the labeled compound was confirmed by paper chromatography at 3 h post-labeling and by human serum albumin (HSA) challenge. PAGE pat...

journal_title：Nuclear medicine and biology

authors： Awasthi V,Gambhir S,Sewatkar AB

更新日期：1994-02-01 00:00:00

abstract：INTRODUCTION:The neurohistological findings in patients treated with targeted beta emitters such as (131)I are poorly described. We report a histopathologic analysis from patients treated with combined external beam therapy and a brachytherapy consisting of a (131)I-labeled monoclonal antibody (mAb) injected into surgi...

journal_title：Nuclear medicine and biology

authors： McLendon RE,Akabani G,Friedman HS,Reardon DA,Cleveland L,Cokgor I,Herndon JE 2nd,Wikstrand C,Boulton ST,Friedman AH,Bigner DD,Zalutsky MR

更新日期：2007-05-01 00:00:00

abstract：INTRODUCTION:The in vitro and in vivo behavior of the radiolabeled monoclonal antibody MORAb-003 was investigated as a prelude to a clinical trial. METHODS:The cellular retention of 111In- and 131I-labeled MORAb-003 was investigated using IGROV1 and SW620 cells. Biodistribution studies in tumor-bearing mice were perfo...

journal_title：Nuclear medicine and biology

authors： Smith-Jones PM,Pandit-Taskar N,Cao W,O'Donoghue J,Philips MD,Carrasquillo J,Konner JA,Old LJ,Larson SM

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:Current guidelines for brain PET imaging advice against the injection of diazepam prior to brain FDG-PET examination in order to avoid possible interactions of benzodiazepines with the radiotracer uptake. Nevertheless, many patients undergoing PET studies are likely to be under chronic treatment with benzo...

journal_title：Nuclear medicine and biology

authors： Silva-Rodríguez J,García-Varela L,López-Arias E,Domínguez-Prado I,Cortés J,Pardo-Montero J,Fernández-Ferreiro A,Ruibal Á,Sobrino T,Aguiar P

更新日期：2016-12-01 00:00:00

abstract：:Positron-emission tomography (PET) provides potential in neuropsychiatric drug development by expanding knowledge of drug action in the living human brain and reducing time consumption and costs. The 5-hydroxytryptamine(1A) (5-HT(1A)) receptor is of central interest as a target for the treatment of anxiety, depression...

journal_title：Nuclear medicine and biology

authors： Andrée B,Halldin C,Thorberg SO,Sandell J,Farde L

更新日期：2000-07-01 00:00:00

abstract：:A simple, rapid, and reproducible micromethod for quantification of sulfhydryl (SH) groups generated after reduction of monoclonal antibody (MAb) disulfide bonds with 2-mercaptoethanol (2-ME) is described. The number of SH groups per molecule of antibody in the 2-ME and in the other reducing agents was calculated from...

journal_title：Nuclear medicine and biology

authors： Iznaga Escobar N,Morales A,Núñez G

更新日期：1996-07-01 00:00:00

abstract：:18Fluoro-norchloroepibatidine (exo-2-(6-fluoro-3-pyridyl)-7-azabicyclo-[2.2.1]heptane [NFEP]), a labeled derivative of epibatidine, has shown promise for imaging brain nicotinic acetylcholine receptors with PET. We determined the dose-dependent effects of NFEP in conscious rats. NFEP (1.5 microg/kg; administered intra...

journal_title：Nuclear medicine and biology

authors： Molina PE,Ding YS,Carroll FI,Liang F,Volkow ND,Pappas N,Kuhar M,Abumrad N,Gatley SJ,Fowler JS

更新日期：1997-11-01 00:00:00

abstract：:Brofaromine (4-5(-methoxy-7-bromobenzofuranyl)-2-piperidine-HCl) is a potent and selective inhibitor of monoamine oxidase (MAO) A. Two methods for its synthesis and a preliminary positron emission tomography (PET) evaluation in monkey brain are described. The first method, at low carrier concentration of CO2, consiste...

journal_title：Nuclear medicine and biology

authors： Ametamey SM,Beer HF,Guenther I,Antonini A,Leenders KL,Waldmeier PC,Schubiger PA

更新日期：1996-04-01 00:00:00

abstract：:The imaging of apoptosis represents an attractive diagnostic goal in the area of tumor therapy, degenerative diseases and organ transplantation. Since caspases play a key role during the early period of the intracellular signal cascade of cells undergoing apoptosis we considered benzyloxycarbonyl-Val-Ala-DL-Asp(O-meth...

journal_title：Nuclear medicine and biology

authors： Haberkorn U,Kinscherf R,Krammer PH,Mier W,Eisenhut M

更新日期：2001-10-01 00:00:00

abstract：:In this study, we present the evaluation of two new ternary ligand (99m)Tc complexes [(99m)Tc(HYNIC tetramer)(tricine)(L)] [L=isonicotinic acid (ISONIC) and 2,5-pyridinedicarboxylic acid (PDA)] as potential radiotracers for tumor imaging. Athymic nude mice bearing MDA-MB-435 human breast cancer xenografts were used to...

journal_title：Nuclear medicine and biology

authors： Liu S,Kim YS,Hsieh WY,Gupta Sreerama S

更新日期：2008-01-01 00:00:00

abstract：:HeLa S-3 cells were treated with 195mPt-radiolabeled trans-diaminedichloroplatinum(II) (TDDP) under various conditions, and the relationship between lethal effect and the number of Pt atoms binding to DNA, RNA and proteins was examined. The mean lethal concentrations for the cells treated with TDDP at 37 degrees C for...

journal_title：Nuclear medicine and biology

authors： Akaboshi M,Kawai K,Maki H,Akuta K,Ujeno Y,Ono K,Miyahara T

更新日期：1993-05-01 00:00:00

abstract：:The serotonin2A (5-HT2A) receptor is implicated in the pathophysiology of schizophrenia and mood disorders, and in vivo studies of this receptor would be of value in studying the pathophysiology of these disorders and in measuring the relationship of clinical response to receptor occupancy for 5-HT2A antagonists such ...

journal_title：Nuclear medicine and biology

authors： Kumar JS,Prabhakaran J,Erlandsson K,Majo VJ,Simpson NR,Pratap M,Van Heertum RL,Mann JJ,Parsey RV

更新日期：2006-05-01 00:00:00

abstract：:A novel approach for the combinatorial synthesis of backbone-derived metal-cyclic peptide libraries is presented. In this approach the metalo-cyclic peptides are prepared from their linear precursors through complexation of a metal atom via two hemi-chelating arms located on the peptide backbone. Thus, cyclization and...

journal_title：Nuclear medicine and biology

authors： Fridkin G,Bonasera TA,Litman P,Gilon C

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Bromodomain and extra-terminal domain (BET) family proteins play a vital role in the epigenetic regulation process by interacting with acetylated lysine (Ac-K) residues in histones. BET inhibitors have become promising candidates to treat various diseases through the inhibition of the interaction between B...

journal_title：Nuclear medicine and biology

authors： Bai P,Lu X,Lan Y,Chen Z,Patnaik D,Fiedler S,Striar R,Haggarty SJ,Wang C

更新日期：2020-01-01 00:00:00

abstract：:The chemokine receptor CXCR4 is highly expressed in tumor cells and plays an important role in tumor metastasis. The aim of this study was to develop a radiopharmaceutical for the imaging of CXCR4-expressing tumors in vivo. Based on structure-activity relationships, we designed a 14-residue peptidic CXCR4 inhibitor, A...

journal_title：Nuclear medicine and biology

authors： Hanaoka H,Mukai T,Tamamura H,Mori T,Ishino S,Ogawa K,Iida Y,Doi R,Fujii N,Saji H

更新日期：2006-05-01 00:00:00

abstract：INTRODUCTION:Prognostic markers for progression of polycystic kidney disease (PKD) are limited. We evaluated the potential of early para-[(18)F]fluorohippurate ([(18)F]PFH) positron emission tomography (PET) renography to predict future progression of PKD in Han:SPRD rats with slowly progressive autosomal dominant PKD....

journal_title：Nuclear medicine and biology

authors： Pathuri G,Hedrick AF,Awasthi V,Cowley BD Jr,Gali H

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to assess the biological behavior of new radiolabeled glucose analogues proposed as tracers of glucose uptake in vivo and iodinated in position 3, 4, or 6. Biological results obtained in vitro on adipocytes and erythrocytes and in vivo in mice were compared to those obtained with the gold-sta...

journal_title：Nuclear medicine and biology

authors： Perret P,Ghezzi C,Ogier L,Abbadi M,Morin C,Mathieu JP,Fagret D

更新日期：2004-02-01 00:00:00

abstract：UNLABELLED:In recent years, several PET and SPECT studies have shown loss of striatal dopamine transporter (DAT) binding in amphetamine (AMPH) users. However, the use of DAT SPECT tracers to detect AMPH-induced changes in DAT binding has not been validated. We therefore examined if repeated administration of D-AMPH or ...

journal_title：Nuclear medicine and biology

authors： Booij J,de Bruin K,Gunning WB

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope (213)Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi(3+), however, hinders the develo...

journal_title：Nuclear medicine and biology

authors： Wilson JJ,Ferrier M,Radchenko V,Maassen JR,Engle JW,Batista ER,Martin RL,Nortier FM,Fassbender ME,John KD,Birnbaum ER

更新日期：2015-05-01 00:00:00

abstract：:The herpes simplex virus type 1 thymidine kinase (HSV1-TK) reporter system is being used to directly and indirectly monitor therapeutic gene expression, immune cell trafficking and protein-protein interactions in various living animals. However, the issues of HSV1-TK enzyme stability in living cells and whether this r...

journal_title：Nuclear medicine and biology

authors： Hsieh CH,Liu RS,Wang HE,Hwang JJ,Deng WP,Chen JC,Chen FD

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:The radiolabeled amino acid O-(2-(18)F-fluoroethyl)-L-tyrosine (FET) and thymidine analogue 3'-deoxy-3'-(18)F-fluorothymidine (FLT) are widely used for positron emission tomography (PET) brain tumor imaging; however, comparative studies are scarce. The aim of this study therefore was to compare FLT and FET P...

journal_title：Nuclear medicine and biology

authors： Nedergaard MK,Michaelsen SR,Perryman L,Erler J,Poulsen HS,Stockhausen MT,Lassen U,Kjaer A

更新日期：2016-03-01 00:00:00

abstract：INTRODUCTION:The cardinal pathological feature of Parkinson's disease (PD) is progressive loss of dopaminergic neurons. Since dopamine transporter (DAT) is a protein located presynaptically on dopaminergic nerve terminals, radioligands that bind to these sites are promising radiopharmaceuticals for evaluation of the in...

journal_title：Nuclear medicine and biology

authors： Liu L,Wang Y,Li B,Jia J,Sun Z,Zhang J,Tian J,Wang X

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:Derived from heavy chain only camelid antibodies, ~15-kDa single-domain antibody fragments (sdAbs) are an attractive platform for developing molecularly specific imaging probes and targeted radiotherapeutics. The rapid tumor accumulation and normal tissue clearance of sdAbs might be ideal for use with 211A...

journal_title：Nuclear medicine and biology

authors： Choi J,Vaidyanathan G,Koumarianou E,Kang CM,Zalutsky MR

更新日期：2018-01-01 00:00:00

abstract：:A no-carrier-added, high specific activity synthesis of [11C-methyl]-thymidine is reported. Reaction of 3'. 5'-O-bis-(tetrahydropyramyl)-5-bromo-2'-deoxyuridine with n-butylithium produced a diamion which was alkylated with [11C]-methyl iodide, and on subsequent hydrolysis, yielded [IIC-methyl]-thymidine. The labeled ...

journal_title：Nuclear medicine and biology

authors： Alauddin MM,Ravert HT,Musachio JL,Mathews WB,Dannals RF,Conti PS

更新日期：1995-08-01 00:00:00

abstract：INTRODUCTION:Pathological formation of fibrosis, is an important feature in many diseases. Fibrosis in liver and pancreas has been associated to metabolic disease including type 1 and 2 diabetes. The current methods for detecting and diagnosing fibrosis are either invasive, or their sensitivity to detect fibrosis in ea...

journal_title：Nuclear medicine and biology

authors： Rosestedt M,Velikyan I,Rosenström U,Estrada S,Åberg O,Weis J,Westerlund C,Ingvast S,Korsgren O,Nordeman P,Eriksson O

更新日期：2020-11-28 00:00:00

abstract：:A paired-label biodistribution was performed in athymic mice bearing SK-N-SH human neuroblastoma xenografts to compare the tissue uptake of meta-[211At]astatobenzylguanidine ([211At]MABG) and [131I]MIBG. Significantly higher (p < 0.05) uptake of [211At]MABG was seen in tumor (3.8 +/- 0.8% ID/g vs. 3.1 +/- 0.7% ID/g at...

journal_title：Nuclear medicine and biology

authors： Vaidyanathan G,Friedman HS,Keir ST,Zalutsky MR

更新日期：1996-08-01 00:00:00