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Tumor resection cavity administered iodine-131-labeled antitenascin 81C6 radioimmunotherapy in patients with malignant glioma: neuropathology aspects.

Abstract：

INTRODUCTION:The neurohistological findings in patients treated with targeted beta emitters such as (131)I are poorly described. We report a histopathologic analysis from patients treated with combined external beam therapy and a brachytherapy consisting of a (131)I-labeled monoclonal antibody (mAb) injected into surgically created resection cavities during brain tumor resections. METHODS:Directed tissue samples of the cavity walls were obtained because of suspected tumor recurrence from 28 patients. Samples and clinical follow-up were evaluated on all patients (Group A) based on total radiation dose received and a subset of these (n=18; Group B, proximal therapy subset) who had received external beam therapy within

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

McLendon RE,Akabani G,Friedman HS,Reardon DA,Cleveland L,Cokgor I,Herndon JE 2nd,Wikstrand C,Boulton ST,Friedman AH,Bigner DD,Zalutsky MR

doi

10.1016/j.nucmedbio.2007.01.009

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

405-13

issue

4

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(07)00036-4

journal_volume

34

pub_type

杂志文章

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