A new 99mTc-complex with a germanium-hydrazide (GeTH) ligand.

Abstract:

:A new tetrahydrazido-germanium (GeTH) ligand was synthesized, characterized and complexed with 99mTc. The negatively charged 99mTc-chelate was shown to form in high yields at neutral pH in the absence of other reducing agents and exhibits high in vitro and in vivo stability.

journal_name

Nucl Med Biol

authors

Singh PR,Katti KK,Katti KV,Corlija M,Ketring AR,Volkert WA,Holmes RR

doi

10.1016/0969-8051(94)90184-8

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

1115-8

issue

8

eissn

0969-8051

issn

1872-9614

journal_volume

21

pub_type

杂志文章
  • A comparative evaluation of the chelators H4octapa and CHX-A″-DTPA with the therapeutic radiometal (90)Y.

    abstract:OBJECTIVES:To compare the radiolabeling performance, stability, and practical efficacy of the chelators CHX-A″-DTPA and H4octapa with the therapeutic radiometal (90)Y. METHODS:The bifunctional chelators p-SCN-Bn-H4octapa and p-SCN-Bn-CHX-A″-DTPA were conjugated to the HER2-targeting antibody trastuzumab. The resulting...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2016.06.004

    authors: Price EW,Edwards KJ,Carnazza KE,Carlin SD,Zeglis BM,Adam MJ,Orvig C,Lewis JS

    更新日期:2016-09-01 00:00:00

  • Determination of the target volume of HeLa cells treated with platinum-195m radiolabeled trans-diaminedichloroplatinum(II): a comparison with cis-diaminedichloroplatinum(II).

    abstract::HeLa S-3 cells were treated with 195mPt-radiolabeled trans-diaminedichloroplatinum(II) (TDDP) under various conditions, and the relationship between lethal effect and the number of Pt atoms binding to DNA, RNA and proteins was examined. The mean lethal concentrations for the cells treated with TDDP at 37 degrees C for...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/0969-8051(93)90068-6

    authors: Akaboshi M,Kawai K,Maki H,Akuta K,Ujeno Y,Ono K,Miyahara T

    更新日期:1993-05-01 00:00:00

  • Cytotoxic and genotoxic effect of the [166Dy]Dy/166Ho-EDTMP in vivo generator system in mice.

    abstract::Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. [(166)Dy]Dy/(166)Ho-ethylenediaminetetramethylene phosphonate (EDTMP) forms a stable in vivo generator system with selective skeletal uptake in mice; therefore, i...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2004.08.010

    authors: Pedraza-López M,Ferro-Flores G,Arteaga de Murphy C,Morales-Ramírez P,Piedras-Ross J,Murphy-Stack E,Hernández-Oviedo O

    更新日期:2004-11-01 00:00:00

  • Compartmental analysis of the pharmacokinetics of radioiodinated monoclonal antibody B72.3 in colon cancer patients.

    abstract::Sixteen patients with colorectal cancer were administered 37-74 MBq (1 mg) of radioiodinated B72.3 monoclonal antibody. Pharmacokinetic analysis was carried out on plasma and urine samples. Elimination from the plasma was biexponential with a mean T1/2 alpha of 3.7 h and T1/2 beta of 62.4 h. The plasma clearance was f...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/0969-8051(93)90136-i

    authors: Reilly RM,Kirsh J,Gallinger S,Thiessen JJ,Damani M,Hay K,Polihronis J,Schmocker B,Odze R,Houle S

    更新日期:1993-01-01 00:00:00

  • Preclinical evaluation of new α-radionuclide therapy targeting LAT1: 2-[211At]astato-α-methyl-L-phenylalanine in tumor-bearing model.

    abstract:INTRODUCTION:Targeted α-radionuclide therapy has attracted attention as a promising therapy for refractory cancers. However, the application is limited to certain types of cancer. Since L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers, we prepared an LAT1-selective α-radionuclide-labe...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2020.08.003

    authors: Ohshima Y,Suzuki H,Hanaoka H,Sasaki I,Watanabe S,Haba H,Arano Y,Tsushima Y,Ishioka NS

    更新日期:2020-01-01 00:00:00

  • [1-11C]octanoate as a potential PET tracer for studying glial functions: PET evaluation in rats and cats.

    abstract::To evaluate the ability of [1-11C]octanoate as a PET tracer for imaging the brain, we examined its distribution in the brain and surrounding tissues in rats and cats with PET. In rats, owing to the accumulated radioactivity in the harderian glands, clear brain images were not obtained at rostral levels. In cats, the b...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/s0969-8051(96)00148-5

    authors: Kuge Y,Kawashima H,Yamazaki S,Hashimoto N,Miyake Y

    更新日期:1996-11-01 00:00:00

  • Evaluation of [18F]Nifene biodistribution and dosimetry based on whole-body PET imaging of mice.

    abstract:INTRODUCTION:[(18)F]Nifene is a novel radiotracer specific to the nicotinic acetylcholine α4β2 receptor class. In preparation for using this tracer in humans we have performed whole-body PET studies in mice to evaluate the in vivo biodistribution and dosimetry of [(18)F]Nifene. METHODS:Seven BALB/c mice (3 males, 4 fe...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2012.11.004

    authors: Constantinescu CC,Garcia A,Mirbolooki MR,Pan ML,Mukherjee J

    更新日期:2013-02-01 00:00:00

  • Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine based on a cartridge purification method.

    abstract:INTRODUCTION:O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) is widely used as a positron emission tomography tracer for brain tumors. Usually, a high-performance liquid chromatography (HPLC) purification at the end of the two-step synthesis is applied. In this work, we report an automatic radiosynthesis of FET with a purifi...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2011.01.006

    authors: Mueller D,Klette I,Kalb F,Baum RP

    更新日期:2011-07-01 00:00:00

  • Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography.

    abstract::We performed preclinical and clinical studies of O-[11C]methyl-L-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-L-tyrosine and the acute toxicity and mutagenicity of O-methyl-L-tyrosine showed s...

    journal_title:Nuclear medicine and biology

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.nucmedbio.2004.11.005

    authors: Ishiwata K,Tsukada H,Kubota K,Nariai T,Harada N,Kawamura K,Kimura Y,Oda K,Iwata R,Ishii K

    更新日期:2005-04-01 00:00:00

  • In vitro metabolism studies of (18)F-labeled 1-phenylpiperazine using mouse liver S9 fraction.

    abstract::The in vitro metabolism of 1-(4-[(18)F]fluoromethylbenzyl)-4-phenylpiperazine ([(18)F]1) and 1-(4-[(18)F]fluorobenzyl)-4-phenylpiperazine ([(18)F]2) was investigated using mouse liver S9 fraction. Results were compared to those of in vivo metabolism using mouse blood and bone and to in vitro metabolism using mouse liv...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2005.12.002

    authors: Ryu EK,Choe YS,Kim DH,Ko BH,Choi Y,Lee KH,Kim BT

    更新日期:2006-02-01 00:00:00

  • 99Mo/(99m)Tc separation: an assessment of technology options.

    abstract::Several strategies for the effective separation of (99m)Tc from (99)Mo have been developed and validated. Due to the success of column chromatographic separation using acidic alumina coupled with high specific activity fission (99)Mo (F (99)Mo) for production of (99)Mo/(99m)Tc generators, however, most technologies un...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.nucmedbio.2012.10.005

    authors: Dash A,Knapp FF Jr,Pillai MR

    更新日期:2013-02-01 00:00:00

  • Influence of pegylation and hapten location at the surface of radiolabelled liposomes on tumour immunotargeting using bispecific antibody.

    abstract:INTRODUCTION:This paper proposes liposomes as a potential new tool for radioimmunotherapy in solid tumours with a two step targeting system. Tumour pretargeting is obtained by using a monoclonal bispecific antibody (BsmAb, anti CEA x anti-DTPA-In) and pegylated liposomes containing lipid-hapten (DSPE-DTPA-In or DSPE-PE...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2013.12.012

    authors: Rauscher A,Frindel M,Maurel C,Maillasson M,Le Saëc P,Rajerison H,Gestin JF,Barbet J,Faivre-Chauvet A,Mougin-Degraef M

    更新日期:2014-05-01 00:00:00

  • Clinical acceptance of a molecular imaging agent: a long march with [99mTc]TRODAT.

    abstract::In the past 10 years, significant progress has been made in using a technetium-99m dopamine transporter imaging agent, [99mTc]TRODAT, for routine clinical studies. Developing a molecular imaging agent from bench to the bedside is more than a simple scientific venture. Currently, Taiwan is the only place where [99mTc]T...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.nucmedbio.2007.03.010

    authors: Kung HF,Kung MP,Wey SP,Lin KJ,Yen TC

    更新日期:2007-10-01 00:00:00

  • Effect of hypoxia on the uptake of [methyl-3H]choline, [1-14C] acetate and [18F]FDG in cultured prostate cancer cells.

    abstract:INTRODUCTION:Choline, acetate and glucose ([2-(18)F]fluoro-2-deoxyglucose, [(18)F]FDG) analogs are under investigation as positron emission tomography (PET) tracers for the imaging of prostate cancer; however, their response to tumor hypoxia has not been clarified. METHODS:The uptake of [methyl-(3)H]choline, [1-(14)C]...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2006.08.002

    authors: Hara T,Bansal A,DeGrado TR

    更新日期:2006-11-01 00:00:00

  • The chemical nature, purity and stability of 99mTc-N-(2,6-Diethyl-3-iodo-phenylcarbamoylmethyl)-iminodiacetic acid.

    abstract::The chemical purity and stability of a radio pharmaceutical 99mTc-N-(2,6-diethyl-3-iodo-phenylcarbamoylmethyl)-iminodiacetic acid (IODIDA) has been studied using HPLC. The HPLC results indicate that IODIDA decomposed into at least three species after 99mTc labelling, and the amount of these varied with time. Mass spec...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/0969-8051(94)00120-9

    authors: Lundberg PS,Jacobsson L,Stenhagen G,Mårtensson J,Fjälling M

    更新日期:1995-05-01 00:00:00

  • Preliminary assessment of extrastriatal dopamine D-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, 18F-fallypride.

    abstract::We have identified the value of 18F-fallypride [(S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide], as a dopamine D-2 receptor radiotracer for the study of striatal and extrastriatal receptors. Fallypride exhibits high affinities for D-2 and D-3 subtypes and low affinity for D-4 (3...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/s0969-8051(99)00012-8

    authors: Mukherjee J,Yang ZY,Brown T,Lew R,Wernick M,Ouyang X,Yasillo N,Chen CT,Mintzer R,Cooper M

    更新日期:1999-07-01 00:00:00

  • Pharmacokinetic computer simulations of the relationship between in vivo and in vitro neuroreceptor subtype selectivity of radioligands.

    abstract::Pharmacokinetic computer simulations reveal a discrepancy between the in vivo and in vitro neuroreceptor subtype selectivity of radioligands. For radioligands with an in vitro neuroreceptor subtype selectivity between 0.1 and 10.0, the in vivo neuroreceptor subtype selectivity appears to be constrained to be between 0...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/s0969-8051(99)00061-x

    authors: Zeeberg BR

    更新日期:1999-10-01 00:00:00

  • Evaluation of a bolus/infusion protocol for 11C-ABP688, a PET tracer for mGluR5.

    abstract:UNLABELLED:(11)C-ABP-688 is a selective tracer for the mGluR5 receptor. Its kinetics is fast and thus favourable for an equilibrium approach to determine receptor-related parameters. The purpose of this study was to test the hypothesis that the pattern of the (11)C-ABP688 uptake using a bolus-plus-infusion (B/I) protoc...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2010.04.107

    authors: Burger C,Deschwanden A,Ametamey S,Johayem A,Mancosu B,Wyss M,Hasler G,Buck A

    更新日期:2010-10-01 00:00:00

  • Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1.

    abstract:INTRODUCTION:Pathological formation of fibrosis, is an important feature in many diseases. Fibrosis in liver and pancreas has been associated to metabolic disease including type 1 and 2 diabetes. The current methods for detecting and diagnosing fibrosis are either invasive, or their sensitivity to detect fibrosis in ea...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2020.11.006

    authors: Rosestedt M,Velikyan I,Rosenström U,Estrada S,Åberg O,Weis J,Westerlund C,Ingvast S,Korsgren O,Nordeman P,Eriksson O

    更新日期:2020-11-28 00:00:00

  • Tetradentate bis-phosphine ligands (P(2)N(2) and P(2)S(2)) and their Rh(III), Ni(II) and (105)Rh complexes: X-ray crystal structures of trans-[RhCl(2)(L2)]PF(6), [Ni(L2)](PF(6))(2) and μ-O(2)SO(2)-[Ni(L5)](2)(PF(6))(2).

    abstract:INTRODUCTION:Tetradentate acyclic and macrocyclic diphosphine ligands (P(2)N(2) and P(2)S(2)) have been synthesized and characterized as potential chelates for Rh(III). METHODS:The coordination complexes [RhCl(2)(L1)]Cl, trans-[RhCl(2)(L2)]PF(6), [Ni(L2)](PF(6))(2), [Ni(L3)](PF(6))(2), [RhCl(2)(L4)]PF(6) and [RhCl(2)(...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2010.06.013

    authors: Cagnolini A,Ballard B,Engelbrecht HP,Rold TL,Barnes C,Cutler C,Hoffman TJ,Kannan R,Katti K,Jurisson SS

    更新日期:2011-01-01 00:00:00

  • [18F]Fluoro-azomycin-2´-deoxy-β-d-ribofuranoside - A new imaging agent for tumor hypoxia in comparison with [18F]FAZA.

    abstract:INTRODUCTION:Radiolabeled 2-nitroimidazoles (azomycins) are a prominent class of biomarkers for PET imaging of hypoxia. [18F]Fluoro-azomycin-α-arabinoside ([18F]FAZA) - already in clinical use - may be seen as α-configuration nucleoside, but enters cells only via diffusion and is not transported by cellular nucleoside ...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2016.08.005

    authors: Schweifer A,Maier F,Ehrlichmann W,Lamparter D,Kneilling M,Pichler BJ,Hammerschmidt F,Reischl G

    更新日期:2016-12-01 00:00:00

  • Pharmacokinetics of the thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) in tumor-bearing rats.

    abstract::The thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) is incorporated into DNA and is resistant to catabolism. We performed pharmacokinetic measurements with [(14)C]FMAU and PET studies with [(11)C]FMAU using rats bearing several different syngeneic tumors. Among normal tissues, FMAU uptake re...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2004.01.001

    authors: Bading JR,Shahinian AH,Vail A,Bathija P,Koszalka GW,Koda RT,Alauddin MM,Fissekis JD,Conti PS

    更新日期:2004-05-01 00:00:00

  • A new nucleophilic fluorine-18 labeling method for aliphatic mesylates: reaction in ionic liquids shows tolerance for water.

    abstract::[see text for equation] Nucleophilic [(18)F]fluorination of some halo- and mesyloxyalkanes to the corresponding [(18)F]fluoroalkanes with fluoride-18 obtained from an (18)O(p,n) [(18)F]F reaction, using an ionic liquid as a reaction medium, has been studied as a new method for fluorine-18 labeling. Of the various ioni...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/s0969-8051(03)00017-9

    authors: Kim DW,Choe YS,Chi DY

    更新日期:2003-05-01 00:00:00

  • Physical optimization of production by deuteron irradiation of high specific activity (177g)Lu suitable for radioimmunotherapy.

    abstract::Deuteron-induced nuclear reactions for generation of no-carrier-added (NCA) Lu isotopes were investigated using the stacked-foil activation technique on natural Yb targets at energies up to Ed=18.18MeV. The decay curve of ¹⁷⁷Yb, the growth curve of the cumulative (direct and indirect) and the direct production of (177...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2014.02.007

    authors: Manenti S,Bonardi ML,Gini L,Groppi F

    更新日期:2014-05-01 00:00:00

  • [⁶⁸Ga]NS₃-RGD and [⁶⁸Ga] Oxo-DO3A-RGD for imaging α(v)β₃ integrin expression: synthesis, evaluation, and comparison.

    abstract:INTRODUCTION:⁶⁸Ga-labeled RGD peptides in combination with PET allow non-invasive determination of α(v)β₃ integrin expression which is highly increased during tumor-induced angiogenesis. The aim of this study was to synthesize and evaluate two RGD peptides containing alternative chelating systems, namely [⁶⁸Ga]NS₃-RGD-...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2012.09.006

    authors: Knetsch PA,Petrik M,Rangger C,Seidel G,Pietzsch HJ,Virgolini I,Decristoforo C,Haubner R

    更新日期:2013-01-01 00:00:00

  • Synthesis and in vivo evaluation of [O-methyl-11C](2R,4R)-4-hydroxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine as a 5-HT2A receptor PET ligand.

    abstract::The serotonin2A (5-HT2A) receptor is implicated in the pathophysiology of schizophrenia and mood disorders, and in vivo studies of this receptor would be of value in studying the pathophysiology of these disorders and in measuring the relationship of clinical response to receptor occupancy for 5-HT2A antagonists such ...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2006.02.001

    authors: Kumar JS,Prabhakaran J,Erlandsson K,Majo VJ,Simpson NR,Pratap M,Van Heertum RL,Mann JJ,Parsey RV

    更新日期:2006-05-01 00:00:00

  • Biodistribution studies of two 18F-labeled pyridinylphenyl amides as subtype selective radioligands for the dopamine D3 receptor.

    abstract:INTRODUCTION:Dopamine D3 receptors are implicated in various neuropsychiatric diseases, drug abuse and alcoholism, but specific agents for D3 molecular imaging are lacking. We evaluated two in vitro selective fluorine-18-labeled radioligand candidates ([(18)F]5 and [(18)F]6) for positron emission tomography (PET) imagi...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/j.nucmedbio.2013.12.014

    authors: Hocke C,Cumming P,Maschauer S,Kuwert T,Gmeiner P,Prante O

    更新日期:2014-03-01 00:00:00

  • Kinetics of the metabolism of four PET radioligands in living minipigs.

    abstract::Most radioligands are substantially metabolised in peripheral organs during the course of positron emission tomography (PET) recordings. Accurate determination of plasma concentrations of unmetabolised radioligands is often important for quantification of data from PET studies. The fractions of untransformed radioliga...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/s0969-8051(00)00187-6

    authors: Gillings NM,Bender D,Falborg L,Marthi K,Munk OL,Cumming P

    更新日期:2001-01-01 00:00:00

  • PET FDG studies in oncology.

    abstract::Positron emission tomography (PET) studies of cancer with the glucose analog 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) have emerged as both a useful research and clinical method for detecting (diagnosing), staging, and monitoring treatment responses in a variety of neoplasms, including tumors of the brain, head and neck,...

    journal_title:Nuclear medicine and biology

    pub_type: 杂志文章

    doi:10.1016/0969-8051(94)90045-0

    authors: Hawkins RA,Hoh CK

    更新日期:1994-07-01 00:00:00

  • Somatostatin receptor scintigraphy during treatment with lanreotide in patients with neuroendocrine tumors.

    abstract::To investigate possible changes in somatostatin receptor expression during treatment with high dose lanreotide, eight patients with neuroendocrine tumors were investigated by [(111)In-DTPA-D-Phe1]-octreotide scintigraphy before and during treatment. The spleen-to-background ratio decreased in all patients, whereas tum...

    journal_title:Nuclear medicine and biology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0969-8051(99)00059-1

    authors: Janson ET,Kälkner KM,Eriksson B,Westlin JE,Oberg K

    更新日期:1999-11-01 00:00:00