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Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography.

Abstract：

:We performed preclinical and clinical studies of O-[11C]methyl-L-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-L-tyrosine and the acute toxicity and mutagenicity of O-methyl-L-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[11C]methyl-L-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[11C]methyl-L-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Ishiwata K,Tsukada H,Kubota K,Nariai T,Harada N,Kawamura K,Kimura Y,Oda K,Iwata R,Ishii K

doi

10.1016/j.nucmedbio.2004.11.005

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

253-62

issue

3

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(04)00181-7

journal_volume

32

pub_type

临床试验,杂志文章

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