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99mTc-insulin: labeling, biodistribution and scintiimaging in animals.

Abstract：

:Porcine insulin was labeled with 99mTc by direct tin reduction. More than 95% labeling efficiency was obtained on paper chromatography in saline and methyl ethyl ketone. The stability of the labeled compound was confirmed by paper chromatography at 3 h post-labeling and by human serum albumin (HSA) challenge. PAGE pattern indicated no change in the electrophoretic behavior and the molecular size of insulin after the labeling procedure. Biodistribution in rats shows that kidney took up the maximum amount of 99mTc-insulin; maxima being maintained throughout 24 h post-injection. Liver and intestine were the other organs with significant uptake; the rest localizing little or negligible radioactivity. Most of the radioactivity was excreted via the renal pathway into urine. Scintiimages conformed to the biodistribution data. The results of this study present the potential of 99mTc-labeling of insulin by a simple method.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Awasthi V,Gambhir S,Sewatkar AB

doi

10.1016/0969-8051(94)90016-7

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

251-4

issue

2

eissn

0969-8051

issn

1872-9614

pii

0969-8051(94)90016-7

journal_volume

21

pub_type

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