2-[18F]Fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors.

abstract：INTRODUCTION:The alpha-7 nicotinic acetylcholine receptor (α7 nAChR) is key in brain communication and has been implicated in the pathophysiology of diseases of the central nervous system. A positron-emitting radioligand targeting the α7 nAChR would enable better understanding of a variety of neuropsychiatric illnesses...

journal_title：Nuclear medicine and biology

authors： Ravert HT,Dorff P,Foss CA,Mease RC,Fan H,Holmquist CR,Phillips E,McCarthy DJ,Heys JR,Holt DP,Wang Y,Endres CJ,Dannals RF,Pomper MG

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:The overexpression of epidermal growth factor receptor (EGFR) in tumors underlines the recent interest in EGFR as attractive target for the development of new cancer imaging agents. EGFR-tyrosine kinase inhibitors (EGFR-TKIs) based on the anilinoquinazoline scaffold have been explored as potential probes f...

journal_title：Nuclear medicine and biology

authors： Neto C,Fernandes C,Oliveira MC,Gano L,Mendes F,Kniess T,Santos I

更新日期：2012-02-01 00:00:00

abstract：:A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation peri...

journal_title：Nuclear medicine and biology

authors： Zalutsky MR,Stabin MG,Larsen RH,Bigner DD

更新日期：1997-04-01 00:00:00

abstract：INTRODUCTION:Sepantronium bromide (YM155) is an antitumor drug in development and is a first-in-class chemical entity, which is a survivin suppressant. We developed a radiosynthesis of [(11)C]YM155 to non-invasively evaluate its tissue and tumor distribution in mice bearing human prostate tumor xenografts. METHODS:Met...

journal_title：Nuclear medicine and biology

authors： Murakami Y,Matsuya T,Kita A,Yamanaka K,Noda A,Mitsuoka K,Nakahara T,Miyoshi S,Nishimura S

更新日期：2013-02-01 00:00:00

abstract：:Asynchronous exponentially growing EL4 murine T lymphoma cells were exposed either to high LET alpha-radiation from 212Bi-DTPA or to gamma-radiation from a 137Cs source. Radiation-induced cell cycle perturbation was studied by flow cytometry. Alpha irradiation, like gamma, transiently arrested cells in the G2M phase i...

journal_title：Nuclear medicine and biology

authors： Palayoor ST,Humm JL,Atcher RW,Hines JJ,Macklis RM

更新日期：1993-08-01 00:00:00

abstract：INTRODUCTION:The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope (213)Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi(3+), however, hinders the develo...

journal_title：Nuclear medicine and biology

authors： Wilson JJ,Ferrier M,Radchenko V,Maassen JR,Engle JW,Batista ER,Martin RL,Nortier FM,Fassbender ME,John KD,Birnbaum ER

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:As the use of metallic radionuclides increases, so does the demand for a simple production method. In this study, we demonstrated an in situ target processing concept for automated metallic radionuclide production without the use of any robotic device. METHODS:An alumina ceramic vessel for a vertical irra...

journal_title：Nuclear medicine and biology

authors： Nagatsu K,Suzuki H,Fukada M,Minegishi K,Tsuji A,Fukumura T

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:We synthesized and evaluated (64)Cu-labeled tetraiodothyroacetic acid (tetrac)-conjugated liposomes for PET imaging of tumor angiogenesis, because tetrac inhibits angiogenesis via integrin αVβ3. METHODS:Tetrac-PEG-DSPE and DOTA-PEG-DSPE were synthesized and formulated with other lipids into liposomes. The...

journal_title：Nuclear medicine and biology

authors： Kang CM,Koo HJ,Lee S,Lee KC,Oh YK,Choe YS

更新日期：2013-11-01 00:00:00

abstract：:The prospective therapeutic, propionyl-L-carnitine, was labelled in the N-methyl position with the positron-emitter, carbon-11 (t1/2 = 20.4 min), with a view to studying its pharmacokinetics in humans using PET. Labelling was achieved by methylating nor-propionyl-L-carnitine hydrochloride with no-carrier-added [11C]io...

journal_title：Nuclear medicine and biology

authors： Davenport RJ,Law MP,Pike VW,Osman S,Poole KG

更新日期：1995-08-01 00:00:00

abstract：INTRODUCTION:Hypoxia plays a negative role in the clinical management of cancer. Detection of hypoxic status of a cancer is important for selecting patients for hypoxia directed therapy. Though [(18)F]fluoromisonidazole ([(18)F]FMISO), a PET radiopharmaceutical, is presently being used in the clinic for the detection o...

journal_title：Nuclear medicine and biology

authors： Mallia MB,Subramanian S,Mathur A,Sarma HD,Banerjee S

更新日期：2014-08-01 00:00:00

abstract：:We propose a renal imaging agent, the 99mTc complex of the bidentate-N,S chelate N-(mercaptoacetyl)glycine (99mTc-2GAM), with the imaging characteristics of 99mTc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99mTc-2GAM as [Tc(v)(O)(GAM)2]-. After biodistribution and toxicity studies i...

journal_title：Nuclear medicine and biology

authors： Gianolli L,Dosio F,Matarrese M,Colombo F,Cutler C,Stepniak-Biniakiewicz D,Deutsch E,Savi A,Lucignani G,Fazio F

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:Herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene in combination with radiolabeled nucleoside substrates is the most widely used reporter system. This study characterized 1-(2'-deoxy-2'-[(18)F]fluoro-β-D-arabinofuranosyl)-5-iodocytosine ((18)F-FIAC) as a new potential positron emission tomography (P...

journal_title：Nuclear medicine and biology

authors： Chan PC,Wu CY,Chang WY,Chang WT,Alauddin M,Liu RS,Lin WJ,Chen FD,Chen CL,Wang HE

更新日期：2011-10-01 00:00:00

abstract：:In connection with pretargeting, an amine-derivatized morpholino phosphorodiamidate oligomer (NH(2)-cMORF) was conjugated conventionally with p-isothiocyanate benzyl-DTPA (p-SCN-Bn-DTPA). However, after (111)In radiolabeling, unexpected label instability was observed. To understand this instability, the NH(2)-cMORF an...

journal_title：Nuclear medicine and biology

authors： Liu G,Dou S,Liu Y,Liang M,Chen L,Cheng D,Greiner D,Rusckowski M,Hnatowich DJ

更新日期：2011-02-01 00:00:00

abstract：:Positron emission tomography (PET), which requires a compound labeled with a positron emitter radioisotope as an imaging probe, is one of the most useful and valuable imaging modalities in molecular imaging. It has several advantages over other imaging modalities, particularly in sensitive and quantitative investigati...

journal_title：Nuclear medicine and biology

authors： Harada R,Furumoto S,Yoshikawa T,Ishikawa Y,Shibuya K,Okamura N,Iwata R,Yanai K

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:The utility of [(18)F]FPBM [2-(2'-((dimethylamino)methyl)-4'-(3-[(18)F]-fluoropropoxy)phenylthio)benzenamine], a selective serotonin transporter (SERT) tracer, and [(18)F]AV-133 [(+)-2-Hydroxy-3-isobutyl-9-(3-fluoropropoxy)-10-methoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine], a selective vesicular m...

journal_title：Nuclear medicine and biology

authors： Wang JL,Oya S,Parhi AK,Lieberman BP,Ploessl K,Hou C,Kung HF

更新日期：2010-05-01 00:00:00

abstract：:The discovery of neuroendocrine differentiation in hormone-refractory prostatic adenocarcinoma has opened a potentially new therapeutic approach in this group of patients with a poor prognosis and few effective therapy modalities. Based on previous findings of increased uptake of 11C-5-hydroxytryptophan (11C-5-HTP) in...

journal_title：Nuclear medicine and biology

authors： Kälkner KM,Ginman C,Nilsson S,Bergström M,Antoni G,Ahlström H,Långström B,Westlin JE

更新日期：1997-05-01 00:00:00

abstract：:A new 99mTc labelling method using a cleavable chelator, RP-1, was developed. In this study Balb/c mice with ovarian carcinoma xenografts received various Fab' fragments labelled with 99mTc either directly or via RP-1. Kidney uptake was significantly lower for the RP-1 linked conjugates. Tumour uptake showed no signif...

journal_title：Nuclear medicine and biology

authors： Tibben JG,Massuger LF,Boerman OC,Claessens RA,Borm GF,Pak KY,Koenders EB,Corstens FH

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to measure functional and structural aspects of local neuroinflammation induced by intracerebral injection of lipopolysaccharide (LPS) in rats using TSPO microPET imaging with [(18)F]DPA-714, magnetic resonance imaging (MRI), in vitro autoradiography and immunohistochemistry (IHC) i...

journal_title：Nuclear medicine and biology

authors： Ory D,Planas A,Dresselaers T,Gsell W,Postnov A,Celen S,Casteels C,Himmelreich U,Debyser Z,Van Laere K,Verbruggen A,Bormans G

更新日期：2015-10-01 00:00:00

abstract：:High-affinity iodine- and ethyl-C-5 substituted analogs of 4-hydroxy-3-(3-[11C]methoxyphenyl)-2(1H)-quinolone ([11C]4HQ) were synthesized as new positron emission tomography radioligands for the glycine-binding sites of the N-methyl-d-aspartate (NMDA) ion channel. Although both radioligands showed high in vitro specif...

journal_title：Nuclear medicine and biology

authors： Fuchigami T,Haradahira T,Fujimoto N,Okauchi T,Maeda J,Suzuki K,Suhara T,Yamamoto F,Sasaki S,Mukai T,Yamaguchi H,Ogawa M,Magata Y,Maeda M

更新日期：2008-02-01 00:00:00

abstract：:To evaluate the ability of [1-11C]octanoate as a PET tracer for imaging the brain, we examined its distribution in the brain and surrounding tissues in rats and cats with PET. In rats, owing to the accumulated radioactivity in the harderian glands, clear brain images were not obtained at rostral levels. In cats, the b...

journal_title：Nuclear medicine and biology

authors： Kuge Y,Kawashima H,Yamazaki S,Hashimoto N,Miyake Y

更新日期：1996-11-01 00:00:00

abstract：:The aim of this study was to assess the biological behavior of new radiolabeled glucose analogues proposed as tracers of glucose uptake in vivo and iodinated in position 3, 4, or 6. Biological results obtained in vitro on adipocytes and erythrocytes and in vivo in mice were compared to those obtained with the gold-sta...

journal_title：Nuclear medicine and biology

authors： Perret P,Ghezzi C,Ogier L,Abbadi M,Morin C,Mathieu JP,Fagret D

更新日期：2004-02-01 00:00:00

abstract：:NCQ 115 ((+)-(R)-5-bromo-N-((1-(4-fluorobenzyl)-2-pyrrolidinyl)methyl)-2, 3-dimethoxybenzamide) is a selective dopamine D-2 receptor antagonist. NCQ 115 has a fluorine in a synthetically suitable position in the parent compound and was therefore suggested as a potential 18F-labelled radioligand for positron emission t...

journal_title：Nuclear medicine and biology

authors： Halldin C,Högberg T,Farde L

更新日期：1994-05-01 00:00:00

abstract：INTRODUCTION:[(18)F]Nifene is a novel radiotracer specific to the nicotinic acetylcholine α4β2 receptor class. In preparation for using this tracer in humans we have performed whole-body PET studies in mice to evaluate the in vivo biodistribution and dosimetry of [(18)F]Nifene. METHODS:Seven BALB/c mice (3 males, 4 fe...

journal_title：Nuclear medicine and biology

authors： Constantinescu CC,Garcia A,Mirbolooki MR,Pan ML,Mukherjee J

更新日期：2013-02-01 00:00:00

abstract：:The aggregative condition of albumin was investigated using bovine serum albumin (BSA) as a model for quality control of 99mTc-macroaggregated albumin (99mTc-MAA). Uniformalized aggregates were obtained from the oxidized non-mercapt-type of BSA by heating. The size of the aggregates was affected by the pH and the type...

journal_title：Nuclear medicine and biology

authors： Fukuoka M,Kobayashi T,Satoh T,Tanaka A,Kubodera A

更新日期：1993-07-01 00:00:00

abstract：INTRODUCTION:The functions of I₂-imidazoline receptors (I₂Rs) are unknown, but evidence exists for their involvement in various neuropsychiatric disorders. Although a few positron emission tomography (PET) I₂R ligands have been developed, of which [(11)C]FTIMD and [(11)C]BU99008 were evaluated as PET I₂R imaging ligand...

journal_title：Nuclear medicine and biology

authors： Kawamura K,Shimoda Y,Kumata K,Fujinaga M,Yui J,Yamasaki T,Xie L,Hatori A,Wakizaka H,Kurihara Y,Ogawa M,Nengaki N,Zhang MR

更新日期：2015-04-01 00:00:00

abstract：UNLABELLED:Several radiopharmaceuticals and imaging techniques are proposed for breast cancer imaging. Since limited data are available of the uptake of SPECT and PET radiopharmaceuticals in malignant breast tumors and their metastases the aim of this study was to compare the uptake values and to correlate these data w...

journal_title：Nuclear medicine and biology

authors： Palmedo H,Hensel J,Reinhardt M,Von Mallek D,Matthies A,Biersack HJ

更新日期：2002-11-01 00:00:00

abstract：:Ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid), a widely-prescribed antibiotic, was labeled with fluorine-18 with the aim to perform positron emission tomography studies in humans for pharmacokinetic measurements. Due to a lack of chemical activation of ciproflox...

journal_title：Nuclear medicine and biology

authors： Langer O,Mitterhauser M,Brunner M,Zeitlinger M,Wadsak W,Mayer BX,Kletter K,Müller M

更新日期：2003-04-01 00:00:00

abstract：INTRODUCTION:Noninvasive imaging of small animals to measure biodistributions and pharmacokinetics of radiolabeled agents is increasingly seen as an effective alternative to external counting of tissues obtained by sacrifice and dissection. However, we have observed important disagreements in measuring the accumulation...

journal_title：Nuclear medicine and biology

authors： Cheng D,Rusckowski M,Pretorius PH,Chen L,Xiao N,Liu Y,Liu G,Liang M,Liu X,Dou S,Hnatowich DJ

更新日期：2011-08-01 00:00:00

abstract：:Two photolabile heterobifunctional O-nitrobenzyl reagents were used to modify B72.3 monoclonal antibody followed by immobilization on a solid support. Antibody was labeled with 99mTc and then cleaved from the resin on irradiation with light of peak intensity at 365 nm. The antibody was restored unmodified after cleava...

journal_title：Nuclear medicine and biology

authors： Ranadive GN,Bloomer WD

更新日期：1995-07-01 00:00:00

abstract：:By variation of reaction parameters iodination of 3-(9,10-didehydro-6-methyl-8 alpha-ergolinyl)-1,1-diethylurea (lisuride) was performed with the radiohalogen [123I]iodine (t1/2 = 13.3 h). For comparative experiments and stability studies the beta(-)-emitting radioisotope [131I]iodine (t1/2 = 8.04 d) was also used. Re...

journal_title：Nuclear medicine and biology

authors： Bier D,Dutschka K,Knust EJ

更新日期：1996-04-01 00:00:00