Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.

Abstract:

:A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered 211At-labeled chimeric 81C6 using a quality factor of 5 for alpha-emissions.

journal_name

Nucl Med Biol

authors

Zalutsky MR,Stabin MG,Larsen RH,Bigner DD

doi

10.1016/s0969-8051(97)00060-7

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

255-61

issue

3

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(97)00060-7

journal_volume

24

pub_type

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