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Comparison of the distribution of radioiodinated di- and tri-hydroxyphenylethylene estrogens in the immature female rat.

Abstract：

:The uptake, retention and tissue to blood ratios of two non-steroidal, 125I-labeled iodoestrogens, an iodotrihydroxyphenylethylene, 2-iodo-1,2-bis(4-hydroxyphenyl)-2-(3-hydroxyphenyl)ethylene and an iododihydroxyphenylethylene, 2-iodo-1,1-bis(4-hydroxyphenyl)-2-phenylethylene, were compared after intraperitoneal injection in immature female rats. The iodotrihydroxyphenylethylene showed an unexpectedly prolonged specific retention in estrogen target tissue, lasting up to 72 h. It was rapidly cleared from blood and non-target tissues so that uterus or ovary to blood ratios of greater than 100 were seen at 2 and 3 days. This iodotrihydroxyphenylethylene may have clinical potential for estrogen receptor-containing cancers.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Desombre ER,Pribish J,Hughes A

doi

10.1016/0969-8051(95)00002-f

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

679-87

issue

5

eissn

0969-8051

issn

1872-9614

pii

0969-8051(95)00002-F

journal_volume

22

pub_type

杂志文章

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