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Compartmental analysis of the pharmacokinetics of radioiodinated monoclonal antibody B72.3 in colon cancer patients.

Abstract：

:Sixteen patients with colorectal cancer were administered 37-74 MBq (1 mg) of radioiodinated B72.3 monoclonal antibody. Pharmacokinetic analysis was carried out on plasma and urine samples. Elimination from the plasma was biexponential with a mean T1/2 alpha of 3.7 h and T1/2 beta of 62.4 h. The plasma clearance was fit to a two-compartmental model. This was combined with a previously reported model for radioiodine to construct a composite model. There was a good correlation (r = 0.952) between the model-predicted and observed excretion of radioiodine suggesting that the composite model is compatible with the pharmacokinetics of the radiolabelled antibody.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Reilly RM,Kirsh J,Gallinger S,Thiessen JJ,Damani M,Hay K,Polihronis J,Schmocker B,Odze R,Houle S

doi

10.1016/0969-8051(93)90136-i

subject

Has Abstract,Author List Incomplete

pub_date

1993-01-01 00:00:00

pages

57-64

issue

1

eissn

0969-8051

issn

1872-9614

pii

0969-8051(93)90136-I

journal_volume

20

pub_type

杂志文章

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