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[125I]iomazenil binding in the brains of spontaneously epileptic rats: an ex vivo quantitative autoradiographic study.

Abstract：

:Central benzodiazepine receptor binding was studied in spontaneously epileptic rats (SER) and in their parent strain. Kyoto-Wistar (KW) rats, by ex vivo quantitative autoradiography with [125I]iomazenil. Thirteen-week-old SER developed tonic and absence-like seizures following mild stimulation by tapping at 5 min before injection of the radioligand. When compared with age-matched KW rats, a significant 76% elevation of radioactivity was observed in the SER hippocampus, while there was no difference in hippocampal blood flow obtained using [125I]N-isopropyl-p-iodoamphetamine. Since benzodiazepine receptors act to enhance inhibitory GABA transmission, this finding suggests a possible mechanism for seizure-induced enhancement of inhibition.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Nagata T,Saji H,Nishizawa S,Yonekura Y,Yamamoto I,Iida Y,Magata Y,Konishi J,Serikawa T,Yokoyama A

doi

10.1016/0969-8051(94)00133-5

subject

Has Abstract,Author List Incomplete

pub_date

1995-05-01 00:00:00

pages

445-9

issue

4

eissn

0969-8051

issn

1872-9614

pii

0969805194001335

journal_volume

22

pub_type

杂志文章

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