Stability and in vivo behavior of Rh[16aneS4-diol]211 at complex: a potential precursor for astatine radiopharmaceuticals.

abstract：INTRODUCTION:We examined whether the amino acid PET tracers, trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic acid (anti-(18)F-FACBC) and (11)C-methyl-l-methionine ((11)C-Met), are suitable for detecting early responses to combination therapies including temozolomide (TMZ), interferon-β (IFN), and bevacizumab (Bev) in...

journal_title：Nuclear medicine and biology

authors： Ono T,Sasajima T,Doi Y,Oka S,Ono M,Kanagawa M,Baden A,Mizoi K,Shimizu H

更新日期：2015-07-01 00:00:00

abstract：:Synthesis and preliminary biological evaluation of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl)-guanine ([18F]FHBG) is reported. 9-(4-Hydroxy-3-hydroxymethylbutyl)-guanine (penciclovir) 4 was converted to 9-[N2, O-bis-(methoxytrityl)-3-(tosylmethybutyl)]guanine 7 by treatment with methoxytrityl chloride followed by tosylat...

journal_title：Nuclear medicine and biology

authors： Alauddin MM,Conti PS

更新日期：1998-04-01 00:00:00

abstract：:The goal of this study was to investigate the potential use of a radioiodinated benzamide, N-[2-(1'-piperidinyl)ethyl]-3-iodo[125I]-4-methoxybenzamide (P[125I]MBA), a sigma receptor binding radioligand for imaging breast cancer. The chemical and radiochemical syntheses of PIMBA are described. The pharmacological evalu...

journal_title：Nuclear medicine and biology

authors： John CS,Bowen WD,Fisher SJ,Lim BB,Geyer BC,Vilner BJ,Wahl RL

更新日期：1999-05-01 00:00:00

abstract：:Quantitative imaging of glucose metabolism of human brain tumors with PET utilizes 2-[(18)F]-fluorodeoxy-D-glucose (FDG) and a conversion factor called the lumped constant (LC), which relates the metabolic rate of FDG to glucose. Since tumors have greater uptake of FDG than would be predicted by the metabolism of nati...

journal_title：Nuclear medicine and biology

authors： Muzi M,Freeman SD,Burrows RC,Wiseman RW,Link JM,Krohn KA,Graham MM,Spence AM

更新日期：2001-02-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) such as the tumor-specific anti-epidermal growth factor receptor variant III (EGFRvIII) that are internalized and degraded after cell binding necessitate the use of radioiodination methods that minimize the loss of radioactivity from the tumor cell after intracellular processing. The purpo...

journal_title：Nuclear medicine and biology

authors： Vaidyanathan G,Affleck DJ,Bigner DD,Zalutsky MR

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Nanoscale perfluorocarbon (PFC) droplets have been used to create imaging agents and drug delivery vehicles. However, development and characterization of new formulations of PFC droplets are hindered because of the lack of simple methods for quantitative and sensitive assessment of whole body tissue distri...

journal_title：Nuclear medicine and biology

authors： Amir N,Green D,Kent J,Xiang Y,Gorelikov I,Seo M,Blacker M,Janzen N,Czorny S,Valliant JF,Matsuura N

更新日期：2017-11-01 00:00:00

abstract：:We compared the influence of three different catechol-O-methyltransferase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabolism of no-carrier-added (NCA) 6-[18F]fluoro-L-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptak...

journal_title：Nuclear medicine and biology

authors： Günther I,Psylla M,Reddy GN,Antonini A,Vontobel P,Reist HW,Zollinger A,Nickles RJ,Beer HF,Schubiger PA

更新日期：1995-10-01 00:00:00

abstract：INTRODUCTION:Nuclear and optical imaging are complementary in many aspects and there would be many advantages when optical imaging probes are prepared using radionuclides rather than classic fluorophores, and when nuclear and optical dual images are obtained using single imaging probe. METHODS:The luminescence intensi...

journal_title：Nuclear medicine and biology

authors： Park JC,Il An G,Park SI,Oh J,Kim HJ,Su Ha Y,Wang EK,Min Kim K,Kim JY,Lee J,Welch MJ,Yoo J

更新日期：2011-04-01 00:00:00

abstract：:Most radioligands are substantially metabolised in peripheral organs during the course of positron emission tomography (PET) recordings. Accurate determination of plasma concentrations of unmetabolised radioligands is often important for quantification of data from PET studies. The fractions of untransformed radioliga...

journal_title：Nuclear medicine and biology

authors： Gillings NM,Bender D,Falborg L,Marthi K,Munk OL,Cumming P

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:A novel compound with the potential for "targeted" therapy for cancer patients was prepared using a conjugate between the potent anticancer drug Gemzar (gemcitabine) and a bisphosphonate. This conjugate would be expected to accumulate at sites of bone metastatic cancer by virtue of an affinity of the bisph...

journal_title：Nuclear medicine and biology

authors： El-Mabhouh AA,Angelov CA,Cavell R,Mercer JR

更新日期：2006-08-01 00:00:00

abstract：INTRODUCTION:Dysregulation of the hepatocyte growth factor (HGF)/MET pathway has been implicated in various cancers. Rilotumumab is an investigational, fully human monoclonal antibody that binds and neutralizes HGF. The purpose of this study was to evaluate the efficacy of rilotumumab in a U-87 MG mouse xenograft tumor...

journal_title：Nuclear medicine and biology

authors： Rex K,Lewis XZ,Gobalakrishnan S,Glaus C,Silva MD,Radinsky R,Burgess TL,Gambhir SS,Coxon A

更新日期：2013-05-01 00:00:00

abstract：UNLABELLED:The evaluation of oxygenation status of solid tumors is an important field of radiopharmaceutical research. With the aim to develop new potential 99mTc-radiopharmaceuticals for imaging hypoxia, we have synthesized two novel isocyanide derivatives of metronidazole, which has demonstrated high affinity for hyp...

journal_title：Nuclear medicine and biology

authors： Giglio J,Fernández S,Pietzsch HJ,Dematteis S,Moreno M,Pacheco JP,Cerecetto H,Rey A

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:Serotonin transporters (SERT) play an important role in controlling serotonin concentration in the synaptic cleft and in managing postsynaptic signal transduction. Inhibitors of SERT binding are well known as selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, sertraline, paroxetine, and esci...

journal_title：Nuclear medicine and biology

authors： Zhang Y,Liu F,Xiao H,Yao X,Li G,Choi SR,Ploessl K,Zha Z,Zhu L,Kung HF

更新日期：2018-11-01 00:00:00

abstract：:At present, P-glycoprotein (P-gp) function can be studied using positron emission tomography (PET) together with a labelled P-gp substrate such as R-[11C]verapamil. Such a tracer is, however, less suitable for investigating P-gp (over)expression. Laniquidar is a third-generation P-gp inhibitor, which has been used in ...

journal_title：Nuclear medicine and biology

authors： Luurtsema G,Schuit RC,Klok RP,Verbeek J,Leysen JE,Lammertsma AA,Windhorst AD

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Imaging of the serotonergic innervation of the brain using positron emission tomography (PET) with the serotonin transporter (SERT) ligand [11C] (+)McN5652 might be affected by serotonin in the synaptic cleft if there is relevant interaction between [11C] (+)McN5652 and serotonin at the SERT. The aim of th...

journal_title：Nuclear medicine and biology

authors： Hummerich R,Schulze O,Rädler T,Mikecz P,Reimold M,Brenner W,Clausen M,Schloss P,Buchert R

更新日期：2006-04-01 00:00:00

abstract：:A new positron emission tomography (PET) radioligand for the serotonin transporter (SERT), [(11)C]2-[2-[[(dimethylamino)methyl]phenyl]thio]-5-(2-fluoroethyl)phenylamine ([(11)C]AFE, 12), was synthesized and evaluated in vivo in rats and baboons. [(11)C]AFE (12) was prepared from its monomethylamino precursor 11 by rea...

journal_title：Nuclear medicine and biology

authors： Zhu Z,Guo N,Narendran R,Erritzoe D,Ekelund J,Hwang DR,Bae SA,Laruelle M,Huang Y

更新日期：2004-11-01 00:00:00

abstract：UNLABELLED:(18)F-9-fluoropropyl-(+)-dihydrotetrabenazine ((18)F-AV-133) is a novel positron emission tomography tracer for imaging the vesicular monoamine transporter II in dopaminergic neuron degeneration, which might be indicative for Parkinson's disease (PD) and other parkinsonism. Studies were performed to optimize...

journal_title：Nuclear medicine and biology

authors： Lin KJ,Lin WY,Hsieh CJ,Weng YH,Wey SP,Lu CS,Skovronsky D,Yen TC,Chang CJ,Kung MP,Hsiao IT

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:This study investigated radiolabeled bacteriophages for specific detection of infection through gamma imaging. Previously, a (99m)Tc-labeled M13 phage demonstrated specific binding for its host Escherichia coli in vitro and in mice through imaging. METHODS:This study was extended to phages P22, E79, VD-13...

journal_title：Nuclear medicine and biology

authors： Rusckowski M,Gupta S,Liu G,Dou S,Hnatowich DJ

更新日期：2008-05-01 00:00:00

abstract：INTRODUCTION:Histone deacetylases (HDACs) are enzymes involved in epigenetic modifications that shift the balance toward chromatin condensation and silencing of gene expression. Here, we evaluate the utility of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide ([(18)F]FAHA) for positron emission tomography imaging of HDAC a...

journal_title：Nuclear medicine and biology

authors： Reid AE,Hooker J,Shumay E,Logan J,Shea C,Kim SW,Collins S,Xu Y,Volkow N,Fowler JS

更新日期：2009-04-01 00:00:00

abstract：:We investigated sigma(1) and dopamine D(2) receptor occupancy in mouse brain after a single injection of haloperidol, nemonapride, or spiperone using [(11)C]SA4503 and [(11)C]raclopride, respectively. Co-injection of the three compounds significantly blocked the uptake of each radioligand. Six hours later, only halope...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Kawamura K,Kobayashi T,Matsuno K

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:The dopamine D4 receptor (D4R) has attracted considerable attention as potential target for the treatment of a broad range of central nervous system disorders. Although many efforts have been made to improve the performance of putative radioligand candidates, there is still a lack of D4R selective tracers ...

journal_title：Nuclear medicine and biology

authors： Willmann M,Ermert J,Prante O,Hübner H,Gmeiner P,Neumaier B

更新日期：2020-07-16 00:00:00

abstract：:Pretargeted tumour imaging was performed in nude mice bearing subcutaneous LS174T human colon cancer xenografts with streptavidin-CC49 monoclonal antibody and 111In-DTPA-biocytin. Mice were administered 250 micrograms of streptavidin-CC49, followed 6 or 9 days later by 40 ng (250 microCi) of 111In-DTPA-biocytin. Tumor...

journal_title：Nuclear medicine and biology

authors： Alvarez-Diez TM,Polihronis J,Reilly RM

更新日期：1996-05-01 00:00:00

abstract：:Metabolic studies of (111)In-DTPA-labeled polypeptides and peptides showed that the radiolabeled (poly)peptides generated (111)In-DTPA-adducts of amino acid that possess long residence times in the lysosomal compartment of the tissues where (poly)peptides accumulated. However, a recent study suggested that metal-chela...

journal_title：Nuclear medicine and biology

authors： Akizawa H,Arano Y,Mifune M,Iwado A,Saito Y,Uehara T,Ono M,Fujioka Y,Ogawa K,Kiso Y,Saji H

更新日期：2001-05-01 00:00:00

abstract：INTRODUCTION:The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope (213)Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi(3+), however, hinders the develo...

journal_title：Nuclear medicine and biology

authors： Wilson JJ,Ferrier M,Radchenko V,Maassen JR,Engle JW,Batista ER,Martin RL,Nortier FM,Fassbender ME,John KD,Birnbaum ER

更新日期：2015-05-01 00:00:00

abstract：:Liver accumulation of 99mTc-DL-homocysteine (99mTc-Hcy), which had been found to accumulate in several experimental tumors, was studied using experimental hepatitis models of rats. The distribution of this compound in liver of rats treated with CCl4 (25-100 microL/100 g body weight) was more than five times higher tha...

journal_title：Nuclear medicine and biology

authors： Takeda A,Okumura H,Okada S

更新日期：1993-11-01 00:00:00

abstract：:[(123)I]AIBZM, (S)-5-[(123)I]-Iodo-N-[(1-ethyl-2-pyrrolidinyl)]methyl-4-amine-2-methoxybenzamide is a derivative with high affinity for the D2 receptor. Labeling was achieved by the Iodogen method. The in vivo affinity for the D2 receptor and the biological characteristics were performed in rats. The brain uptake of [...

journal_title：Nuclear medicine and biology

authors： Li H,Gildehaus FJ,Dresel S,Patt JT,Shen M,Zhu T,Liu B,Tang Z,Tatsch K,Hahn K

更新日期：2001-05-01 00:00:00

abstract：INTRODUCTION:Image-derived input functions (IDIFs) represent a promising non-invasive alternative to arterial blood sampling for quantification in positron emission tomography (PET) studies. However, routine applications in patients and longitudinal designs are largely missing despite widespread attempts in healthy sub...

journal_title：Nuclear medicine and biology

authors： Hahn A,Nics L,Baldinger P,Wadsak W,Savli M,Kraus C,Birkfellner W,Ungersboeck J,Haeusler D,Mitterhauser M,Karanikas G,Kasper S,Frey R,Lanzenberger R

更新日期：2013-04-01 00:00:00

abstract：:The serotonin2A (5-HT2A) receptor is implicated in the pathophysiology of schizophrenia and mood disorders, and in vivo studies of this receptor would be of value in studying the pathophysiology of these disorders and in measuring the relationship of clinical response to receptor occupancy for 5-HT2A antagonists such ...

journal_title：Nuclear medicine and biology

authors： Kumar JS,Prabhakaran J,Erlandsson K,Majo VJ,Simpson NR,Pratap M,Van Heertum RL,Mann JJ,Parsey RV

更新日期：2006-05-01 00:00:00

abstract：:Positron emission tomography (PET), which requires a compound labeled with a positron emitter radioisotope as an imaging probe, is one of the most useful and valuable imaging modalities in molecular imaging. It has several advantages over other imaging modalities, particularly in sensitive and quantitative investigati...

journal_title：Nuclear medicine and biology

authors： Harada R,Furumoto S,Yoshikawa T,Ishikawa Y,Shibuya K,Okamura N,Iwata R,Yanai K

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Radiolabeled gastrin analogs represent attractive candidates for diagnosis and therapy of cholecystokinin subtype-2 receptor (CCK2R)-expressing tumors. Radiolabeled des(Glu)5-gastrins show favorably low renal accumulation, but localize poorly in CCK2R-positive lesions. We introduce herein three truncated [...

journal_title：Nuclear medicine and biology

authors： Kaloudi A,Nock BA,Lymperis E,Sallegger W,Krenning EP,de Jong M,Maina T

更新日期：2015-11-01 00:00:00