Sigma1 and dopamine D2 receptor occupancy in the mouse brain after a single administration of haloperidol and two dopamine D2-like receptor ligands.

Abstract:

:We investigated sigma(1) and dopamine D(2) receptor occupancy in mouse brain after a single injection of haloperidol, nemonapride, or spiperone using [(11)C]SA4503 and [(11)C]raclopride, respectively. Co-injection of the three compounds significantly blocked the uptake of each radioligand. Six hours later, only haloperidol blocked [(11)C]SA4503 uptake, while all three reduced [(11)C]raclopride uptake. Sigma(1) receptor occupancy by haloperidol was reduced to 19% at day 2 when D(2) receptor occupancy disappeared. [(11)C]SA4503 would be applicable to the investigation of sigma(1) receptor occupancy of antispychotic drugs using PET.

journal_name

Nucl Med Biol

authors

Ishiwata K,Kawamura K,Kobayashi T,Matsuno K

doi

10.1016/s0969-8051(03)00003-9

keywords:

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

429-34

issue

4

eissn

0969-8051

issn

1872-9614

pii

S0969805103000039

journal_volume

30

pub_type

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