Kinetics of the metabolism of four PET radioligands in living minipigs.

abstract：INTRODUCTION:Dysregulation of the hepatocyte growth factor (HGF)/MET pathway has been implicated in various cancers. Rilotumumab is an investigational, fully human monoclonal antibody that binds and neutralizes HGF. The purpose of this study was to evaluate the efficacy of rilotumumab in a U-87 MG mouse xenograft tumor...

journal_title：Nuclear medicine and biology

authors： Rex K,Lewis XZ,Gobalakrishnan S,Glaus C,Silva MD,Radinsky R,Burgess TL,Gambhir SS,Coxon A

更新日期：2013-05-01 00:00:00

abstract：:The ability to measure blood flow to tumors non-invasively may be of importance in monitoring tumor therapies, assessing drug delivery, and understanding tumor physiology. Of all the radiotracer methods that have been proposed to measure tumor blood flow, the method based on labeled water-H(2)(15)O-may be the most app...

journal_title：Nuclear medicine and biology

authors： Bacharach SL,Libutti SK,Carrasquillo JA

更新日期：2000-10-01 00:00:00

abstract：:A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation peri...

journal_title：Nuclear medicine and biology

authors： Zalutsky MR,Stabin MG,Larsen RH,Bigner DD

更新日期：1997-04-01 00:00:00

abstract：:Deuteron-induced nuclear reactions for generation of no-carrier-added (NCA) Lu isotopes were investigated using the stacked-foil activation technique on natural Yb targets at energies up to Ed=18.18MeV. The decay curve of ¹⁷⁷Yb, the growth curve of the cumulative (direct and indirect) and the direct production of (177...

journal_title：Nuclear medicine and biology

authors： Manenti S,Bonardi ML,Gini L,Groppi F

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:The alpha-7 nicotinic acetylcholine receptor (α7 nAChR) is key in brain communication and has been implicated in the pathophysiology of diseases of the central nervous system. A positron-emitting radioligand targeting the α7 nAChR would enable better understanding of a variety of neuropsychiatric illnesses...

journal_title：Nuclear medicine and biology

authors： Ravert HT,Dorff P,Foss CA,Mease RC,Fan H,Holmquist CR,Phillips E,McCarthy DJ,Heys JR,Holt DP,Wang Y,Endres CJ,Dannals RF,Pomper MG

更新日期：2013-08-01 00:00:00

abstract：:We are interested in imaging cell death in vivo using annexin V radiolabeled with (124)I. In this study, [(124)I]4IB-annexin V and [(124)I]4IB-ovalbumin were made using [(124)I]N-hydroxysuccinimidyl-4-iodobenzoate prepared by iododestannylation of N-hydroxysuccinimidyl-4-(tributylstannyl)benzoate. [(124)I]4IB-annexin ...

journal_title：Nuclear medicine and biology

authors： Dekker B,Keen H,Shaw D,Disley L,Hastings D,Hadfield J,Reader A,Allan D,Julyan P,Watson A,Zweit J

更新日期：2005-05-01 00:00:00

abstract：:Quantitative imaging of glucose metabolism of human brain tumors with PET utilizes 2-[(18)F]-fluorodeoxy-D-glucose (FDG) and a conversion factor called the lumped constant (LC), which relates the metabolic rate of FDG to glucose. Since tumors have greater uptake of FDG than would be predicted by the metabolism of nati...

journal_title：Nuclear medicine and biology

authors： Muzi M,Freeman SD,Burrows RC,Wiseman RW,Link JM,Krohn KA,Graham MM,Spence AM

更新日期：2001-02-01 00:00:00

abstract：INTRODUCTION:Our objective was to evaluate the effect of epidermal growth factor receptor(s) (EGFR) density on the importation and nuclear localization of 111In-labeled diethylenetriaminepentaacetic acid human epidermal growth factor ([111In]DTPA-hEGF) in breast cancer (BC) cells in vitro and in tumor xenografts and no...

journal_title：Nuclear medicine and biology

authors： Hu M,Scollard D,Chan C,Chen P,Vallis K,Reilly RM

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope (213)Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi(3+), however, hinders the develo...

journal_title：Nuclear medicine and biology

authors： Wilson JJ,Ferrier M,Radchenko V,Maassen JR,Engle JW,Batista ER,Martin RL,Nortier FM,Fassbender ME,John KD,Birnbaum ER

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:The identification of sentinel lymph nodes (SLNs) is important in deciding the resection range during surgery. 99mTc-labeled mannosylated human serum albumin ([99mTc]Tc-MSA) is a radiopharmaceutical developed for SLN detection by targeting macrophages. Evans blue (EB) is a blue dye binding strongly to albu...

journal_title：Nuclear medicine and biology

authors： Lee JY,Kim HY,Lee YS,Seo HY,Park JY,Jeong JM

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:[(18)F]Nifene is a novel radiotracer specific to the nicotinic acetylcholine α4β2 receptor class. In preparation for using this tracer in humans we have performed whole-body PET studies in mice to evaluate the in vivo biodistribution and dosimetry of [(18)F]Nifene. METHODS:Seven BALB/c mice (3 males, 4 fe...

journal_title：Nuclear medicine and biology

authors： Constantinescu CC,Garcia A,Mirbolooki MR,Pan ML,Mukherjee J

更新日期：2013-02-01 00:00:00

abstract：:We propose a renal imaging agent, the 99mTc complex of the bidentate-N,S chelate N-(mercaptoacetyl)glycine (99mTc-2GAM), with the imaging characteristics of 99mTc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99mTc-2GAM as [Tc(v)(O)(GAM)2]-. After biodistribution and toxicity studies i...

journal_title：Nuclear medicine and biology

authors： Gianolli L,Dosio F,Matarrese M,Colombo F,Cutler C,Stepniak-Biniakiewicz D,Deutsch E,Savi A,Lucignani G,Fazio F

更新日期：1996-11-01 00:00:00

abstract：:A new tetrahydrazido-germanium (GeTH) ligand was synthesized, characterized and complexed with 99mTc. The negatively charged 99mTc-chelate was shown to form in high yields at neutral pH in the absence of other reducing agents and exhibits high in vitro and in vivo stability. ...

journal_title：Nuclear medicine and biology

authors： Singh PR,Katti KK,Katti KV,Corlija M,Ketring AR,Volkert WA,Holmes RR

更新日期：1994-11-01 00:00:00

abstract：INTRODUCTION:O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) is widely used as a positron emission tomography tracer for brain tumors. Usually, a high-performance liquid chromatography (HPLC) purification at the end of the two-step synthesis is applied. In this work, we report an automatic radiosynthesis of FET with a purifi...

journal_title：Nuclear medicine and biology

authors： Mueller D,Klette I,Kalb F,Baum RP

更新日期：2011-07-01 00:00:00

abstract：INTRODUCTION:3'-Deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) shows great potential as a tracer for proliferative studies with PET. However, its regular application is often limited by low radiochemical yields and the use of a troublesome HPLC separation. Moreover, a high content of ethanol, at least one-fold higher tha...

journal_title：Nuclear medicine and biology

authors： Pascali C,Bogni A,Fugazza L,Cucchi C,Crispu O,Laera L,Iwata R,Maiocchi G,Crippa F,Bombardieri E

更新日期：2012-05-01 00:00:00

abstract：:Poly(adenosine diphosphate-ribose) synthetase (PARS) is a nuclear enzyme that is activated by deoxyribonucleic acid (DNA) strand breaks and participates in DNA repair. Excessive PARS activation, however, leads to cell death due to depletion of adenosine triphosphate (ATP). To evaluate whether it is possible to detect ...

journal_title：Nuclear medicine and biology

authors： Miyake Y,Kuge Y,Shimadzu H,Hashimoto N,Ishida Y,Shibakawa M,Nishimura T

更新日期：2000-11-01 00:00:00

abstract：:Stavudine, a potent antiviral agent for treating human immunodeficiency virus (HIV) infections, was radiolabeled with (11)C by methylation of a specifically designed precursor, 5'-O-(2-tetrahydropyranyl)-5-bromo-2',3'-didehydro-3'-deoxythymidine, with (11)C H(3)I. The radiolabeled drug was isolated by reverse phase HP...

journal_title：Nuclear medicine and biology

authors： Livni E,Berker M,Hillier S,Waller SC,Ogan MD,Discordia RP,Rienhart JK,Rubin RH,Fischman AJ

更新日期：2004-07-01 00:00:00

abstract：:The imaging of apoptosis represents an attractive diagnostic goal in the area of tumor therapy, degenerative diseases and organ transplantation. Since caspases play a key role during the early period of the intracellular signal cascade of cells undergoing apoptosis we considered benzyloxycarbonyl-Val-Ala-DL-Asp(O-meth...

journal_title：Nuclear medicine and biology

authors： Haberkorn U,Kinscherf R,Krammer PH,Mier W,Eisenhut M

更新日期：2001-10-01 00:00:00

abstract：:New oxotechnetium complexes of general formula [99mTc(O)(PNS)(S(CH2)nOSiR3)] (4-6) were synthesized by direct reduction of [99mTcO4]- with stannous chloride, in the presence of the tridentate heterofunctionalized phosphine H2PNS and of the monodentate silylated thiols [HS(CH2)nOSiR3] (n = 2, R = Ph (1); n = 3, R = Ph ...

journal_title：Nuclear medicine and biology

authors： Fernandes C,Kniess T,Gano L,Seifert S,Spies H,Santos I

更新日期：2004-08-01 00:00:00

abstract：:We describe the synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ), which differs from the typically used [(18)F]fluoroethylflumazenil (FEFMZ) for benzodiazepine receptor imaging. For one-pot one-step labeling, the precursors, 2'-tosyloxyflumazenil (TFMZ) and 2'-mesyloxyflumazenil (MFMZ), were synthesized in three steps. ...

journal_title：Nuclear medicine and biology

authors： Yoon YH,Jeong JM,Kim HW,Hong SH,Lee YS,Kil HS,Chi DY,Lee DS,Chung JK,Lee MC

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION:Targeted α-radionuclide therapy has attracted attention as a promising therapy for refractory cancers. However, the application is limited to certain types of cancer. Since L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers, we prepared an LAT1-selective α-radionuclide-labe...

journal_title：Nuclear medicine and biology

authors： Ohshima Y,Suzuki H,Hanaoka H,Sasaki I,Watanabe S,Haba H,Arano Y,Tsushima Y,Ishioka NS

更新日期：2020-01-01 00:00:00

abstract：:Chondroitin sulfate (CS) is used in the treatment of human osteoarthritis as a slow-acting symptomatic drug. For this reason, we performed uptake studies with (99m)TcCS using different chondrocyte cultures, as well as cartilage tissue in vitro. For uptake studies, adherent monolayer cultures of human chondrocytes (2.7...

journal_title：Nuclear medicine and biology

authors： Sobal G,Menzel J,Sinzinger H

更新日期：2009-01-01 00:00:00

abstract：:An increasing interest in zirconium-89 (89Zr) can be attributed to the isotope's half-life which is compatible with antibody imaging using positron emission tomography (PET). The goal of this work was to develop an efficient means of production for 89Zr that provides this isotope with high radionuclidic purity and spe...

journal_title：Nuclear medicine and biology

authors： Queern SL,Aweda TA,Massicano AVF,Clanton NA,El Sayed R,Sader JA,Zyuzin A,Lapi SE

更新日期：2017-07-01 00:00:00

abstract：:We report a single pass gas phase route to [11C]CH3I based on production of I from I2 at elevated temperature. I abstracts H from CH4 to yield CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessi...

journal_title：Nuclear medicine and biology

authors： Link JM,Krohn KA,Clark JC

更新日期：1997-01-01 00:00:00

abstract：:The pituitary gonadotropins FSH and LH are secreted into blood as dimeric glycoproteins which display a wide heterogeneity when submitted to technique of separation based on electric charge. That supports the assumption of a major role of the carbohydrates moieties as a source of heterogeneity. No clear difference how...

journal_title：Nuclear medicine and biology

authors： Roger M,Lalhou N

更新日期：1994-04-01 00:00:00

abstract：:Packed capillary liquid chromatography with electrospray mass spectrometry was used for direct determination of the specific radioactivity by calculation of isotope ratios between the (76)Br- and (79)Br-labeled analogues of N-((3-aminomethyl)benzyl)-4-bromobenzamide. Using 20 microL injections on packed capillary colu...

journal_title：Nuclear medicine and biology

authors： Forngren BH,Yngve U,Forngren T,Långström B

更新日期：2000-11-01 00:00:00

abstract：:To evaluate the ability of [1-11C]octanoate as a PET tracer for imaging the brain, we examined its distribution in the brain and surrounding tissues in rats and cats with PET. In rats, owing to the accumulated radioactivity in the harderian glands, clear brain images were not obtained at rostral levels. In cats, the b...

journal_title：Nuclear medicine and biology

authors： Kuge Y,Kawashima H,Yamazaki S,Hashimoto N,Miyake Y

更新日期：1996-11-01 00:00:00

abstract：:A new 99mTc labelling method using a cleavable chelator, RP-1, was developed. In this study Balb/c mice with ovarian carcinoma xenografts received various Fab' fragments labelled with 99mTc either directly or via RP-1. Kidney uptake was significantly lower for the RP-1 linked conjugates. Tumour uptake showed no signif...

journal_title：Nuclear medicine and biology

authors： Tibben JG,Massuger LF,Boerman OC,Claessens RA,Borm GF,Pak KY,Koenders EB,Corstens FH

更新日期：1994-01-01 00:00:00

abstract：:The niobium-90 radioisotope ((90)Nb) holds considerable promise for use in immuno-PET, due to its decay parameters (t½ = 14.6h, positron yield=53%, Eß(+)(mean) = 0.35 MeV and Eß(+)(max) = 1.5 MeV). In particular, (90)Nb appears well suited to detect in vivo the pharmacokinetics of large targeting vectors (50-150 kDa)....

journal_title：Nuclear medicine and biology

authors： Radchenko V,Busse S,Roesch F

更新日期：2014-10-01 00:00:00

abstract：:The uptake, retention and tissue to blood ratios of two non-steroidal, 125I-labeled iodoestrogens, an iodotrihydroxyphenylethylene, 2-iodo-1,2-bis(4-hydroxyphenyl)-2-(3-hydroxyphenyl)ethylene and an iododihydroxyphenylethylene, 2-iodo-1,1-bis(4-hydroxyphenyl)-2-phenylethylene, were compared after intraperitoneal injec...

journal_title：Nuclear medicine and biology

authors： Desombre ER,Pribish J,Hughes A

更新日期：1995-07-01 00:00:00