Abstract:
:[(123)I]AIBZM, (S)-5-[(123)I]-Iodo-N-[(1-ethyl-2-pyrrolidinyl)]methyl-4-amine-2-methoxybenzamide is a derivative with high affinity for the D2 receptor. Labeling was achieved by the Iodogen method. The in vivo affinity for the D2 receptor and the biological characteristics were performed in rats. The brain uptake of [(123)I]AIBZM was significantly lower, however the striatum/cerebellum ratio (2h p.i.) was higher than that of [(123)I]IBZM. Because of the high affinity and its possibly lower unspecific binding compared to [(123)I]IBZM, [(123)I]AIBZM may be a potential imaging agent for the D2 dopamine receptor.
journal_name
Nucl Med Bioljournal_title
Nuclear medicine and biologyauthors
Li H,Gildehaus FJ,Dresel S,Patt JT,Shen M,Zhu T,Liu B,Tang Z,Tatsch K,Hahn Kkeywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
383-9issue
4eissn
0969-8051issn
1872-9614pii
S0969-8051(01)00199-8journal_volume
28pub_type
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