Comparison of in vivo dopamine D2 receptor binding of [(123)I]AIBZM and [(123)I]IBZM in rat brain.

Abstract:

:[(123)I]AIBZM, (S)-5-[(123)I]-Iodo-N-[(1-ethyl-2-pyrrolidinyl)]methyl-4-amine-2-methoxybenzamide is a derivative with high affinity for the D2 receptor. Labeling was achieved by the Iodogen method. The in vivo affinity for the D2 receptor and the biological characteristics were performed in rats. The brain uptake of [(123)I]AIBZM was significantly lower, however the striatum/cerebellum ratio (2h p.i.) was higher than that of [(123)I]IBZM. Because of the high affinity and its possibly lower unspecific binding compared to [(123)I]IBZM, [(123)I]AIBZM may be a potential imaging agent for the D2 dopamine receptor.

journal_name

Nucl Med Biol

authors

Li H,Gildehaus FJ,Dresel S,Patt JT,Shen M,Zhu T,Liu B,Tang Z,Tatsch K,Hahn K

keywords:

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

383-9

issue

4

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(01)00199-8

journal_volume

28

pub_type

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