Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats.

abstract：INTRODUCTION:Choline, acetate and glucose ([2-(18)F]fluoro-2-deoxyglucose, [(18)F]FDG) analogs are under investigation as positron emission tomography (PET) tracers for the imaging of prostate cancer; however, their response to tumor hypoxia has not been clarified. METHODS:The uptake of [methyl-(3)H]choline, [1-(14)C]...

journal_title：Nuclear medicine and biology

authors： Hara T,Bansal A,DeGrado TR

更新日期：2006-11-01 00:00:00

abstract：INTRODUCTION:Porphyrin and its derivatives exhibit inherent affinity for localization in tumors. Hence, porphyrin derivatives radiolabeled with suitable therapeutic radionuclides could be envisaged as potential agents for targeted tumor therapy. In this direction, a water-soluble porphyrin derivative, viz., 5,10,15,20-...

journal_title：Nuclear medicine and biology

authors： Das T,Chakraborty S,Sarma HD,Banerjee S,Venakatesh M

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:HDAC6, a structural and functional distinct member of the HDAC-family, shows great promise as a target to treat several cancers and neurodegenerative diseases. Several clinical trials are evaluating HDAC6 inhibitors in solid tumours and haematological malignancies, but so far no HDAC6 inhibitor has receive...

journal_title：Nuclear medicine and biology

authors： Vermeulen K,Ahamed M,Luyten K,Bormans G

更新日期：2019-01-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) such as the tumor-specific anti-epidermal growth factor receptor variant III (EGFRvIII) that are internalized and degraded after cell binding necessitate the use of radioiodination methods that minimize the loss of radioactivity from the tumor cell after intracellular processing. The purpo...

journal_title：Nuclear medicine and biology

authors： Vaidyanathan G,Affleck DJ,Bigner DD,Zalutsky MR

更新日期：2002-01-01 00:00:00

abstract：:We describe the synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ), which differs from the typically used [(18)F]fluoroethylflumazenil (FEFMZ) for benzodiazepine receptor imaging. For one-pot one-step labeling, the precursors, 2'-tosyloxyflumazenil (TFMZ) and 2'-mesyloxyflumazenil (MFMZ), were synthesized in three steps. ...

journal_title：Nuclear medicine and biology

authors： Yoon YH,Jeong JM,Kim HW,Hong SH,Lee YS,Kil HS,Chi DY,Lee DS,Chung JK,Lee MC

更新日期：2003-07-01 00:00:00

abstract：:Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [18O]O2. A method for the routine production of clinically useful quantities of [18F]F2 having a specific activity of 35 Ci/mmol has been developed...

journal_title：Nuclear medicine and biology

authors： Chirakal R,Adams RM,Firnau G,Schrobilgen GJ,Coates G,Garnett ES

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:Established radiotracers for positron emission tomography (PET) myocardial perfusion study are commonly labeled with short-lived radio-isotopes that limit their widespread clinical use. Thus, we synthesized (2-(2-[(18)F]fluoroethoxy)ethyl)tris(4-methoxyphenyl)phosphonium salt ([(18)F]FETMP) as a novel myoc...

journal_title：Nuclear medicine and biology

authors： Kim DY,Kim HJ,Yu KH,Min JJ

更新日期：2012-10-01 00:00:00

abstract：UNLABELLED:The radiolabelled bombesin analogue AMBA shows high potential for diagnosis and treatment of prostate and breast cancer, but the influence of different chelators, which differ in terms of radiochemical reactivity and stability, have not been explored so far. In order to find the best suitable chelator for la...

journal_title：Nuclear medicine and biology

authors： Asti M,Iori M,Capponi PC,Atti G,Rubagotti S,Martin R,Brennauer A,Müller M,Bergmann R,Erba PA,Versari A

更新日期：2014-01-01 00:00:00

abstract：:We present a method for estimating 99mTc-MAG3 clearance from both a single injection and two blood samples that is valid for both adults and children. It was obtained by fitting a scaled two-compartment model (having only two adjustable parameters) to adult and pediatric data from multiple centers. ...

journal_title：Nuclear medicine and biology

authors： Russell CD,Taylor AT Jr,Dubovsky EV,Eshima D

更新日期：1995-01-01 00:00:00

abstract：:The anabolism of isotopically labeled amino acids was compared between the cerebrum and the cerebellum in conscious rat at three feeding conditions. After L-[2-18F]fluorophenylalanine and L-[2,6-3H]phenylalanine injections, the incorporation rate of both radioactivity into protein fraction showed no difference between...

journal_title：Nuclear medicine and biology

authors： Nakamichi H,Murakami M,Miura S,Kondoh Y,Mizusawa S,Ono Y

更新日期：1994-10-01 00:00:00

abstract：INTRODUCTION:Radiolabeled 2-nitroimidazoles (azomycins) are a prominent class of biomarkers for PET imaging of hypoxia. [18F]Fluoro-azomycin-α-arabinoside ([18F]FAZA) - already in clinical use - may be seen as α-configuration nucleoside, but enters cells only via diffusion and is not transported by cellular nucleoside ...

journal_title：Nuclear medicine and biology

authors： Schweifer A,Maier F,Ehrlichmann W,Lamparter D,Kneilling M,Pichler BJ,Hammerschmidt F,Reischl G

更新日期：2016-12-01 00:00:00

abstract：:Antimicrobial peptides have been proposed as new agents to distinguish between bacterial infections and sterile inflammatory processes. (99m)Tc-UBI labeled by a direct method has shown high in vitro and in vivo stability, specific uptake at the site of infection, rapid background clearance, minimal accumulation in non...

journal_title：Nuclear medicine and biology

authors： Meléndez-Alafort L,Rodríguez-Cortés J,Ferro-Flores G,Arteaga De Murphy C,Herrera-Rodríguez R,Mitsoura E,Martínez-Duncker C

更新日期：2004-04-01 00:00:00

abstract：:In connection with pretargeting, an amine-derivatized morpholino phosphorodiamidate oligomer (NH(2)-cMORF) was conjugated conventionally with p-isothiocyanate benzyl-DTPA (p-SCN-Bn-DTPA). However, after (111)In radiolabeling, unexpected label instability was observed. To understand this instability, the NH(2)-cMORF an...

journal_title：Nuclear medicine and biology

authors： Liu G,Dou S,Liu Y,Liang M,Chen L,Cheng D,Greiner D,Rusckowski M,Hnatowich DJ

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:Telmisartan, a nonpeptide angiotensin II AT1 receptor antagonist used as an antihypertensive drug, is specifically taken up by the liver through the OATP1B3. PET imaging with [(11)C]telmisartan is expected to provide information about the whole body pharmacokinetics of telmisartan as well as its transport ...

journal_title：Nuclear medicine and biology

authors： Shimizu K,Takashima T,Yamane T,Sasaki M,Kageyama H,Hashizume Y,Maeda K,Sugiyama Y,Watanabe Y,Senda M

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Currently, the reference method of brown adipose tissue (BAT) imaging is 18F-fluorodeoxyglucose positron emission tomography ([18F]FDG PET). BAT imaging by [18F]FDG PET requires additional stimulation process, which is inconvenient and hard to be standardized. The translocator protein 18 kDa (TSPO) PET has...

journal_title：Nuclear medicine and biology

authors： Oh C,Song IH,Lee W,Jeon M,Choi J,Baek S,Lee BC,Kim SE,Im HJ

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Noninvasive imaging of small animals to measure biodistributions and pharmacokinetics of radiolabeled agents is increasingly seen as an effective alternative to external counting of tissues obtained by sacrifice and dissection. However, we have observed important disagreements in measuring the accumulation...

journal_title：Nuclear medicine and biology

authors： Cheng D,Rusckowski M,Pretorius PH,Chen L,Xiao N,Liu Y,Liu G,Liang M,Liu X,Dou S,Hnatowich DJ

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:Myocardial perfusion gating techniques offer the possibility of measurement of left ventricular end-systolic (ESV) and end-diastolic volume (EDV) and left ventricular ejection fraction (LVEF) in clinical and preclinical trials. The aim of this study was to evaluate left ventricular volumes (LVV) and LVEF w...

journal_title：Nuclear medicine and biology

authors： Szymanski MK,Kruizinga S,Tio RA,Willemsen AT,Schäfers MA,Stegger L,Dierckx RA,Hillege HL,Slart RH

更新日期：2012-07-01 00:00:00

abstract：:The in vitro stability and animal pharmacokinetics of 99mTc bound to Sandoz and C110 IgG antibodies via a modified MAG3 has been compared with the hydrazino nicotinamide (SHNH) moiety as standard. For both antibodies, the stabilities of the label to challenge at up to 50:1 cysteine: IgG molar ratio were comparable, bu...

journal_title：Nuclear medicine and biology

authors： Lei K,Rusckowski M,Chang F,Qu T,Mardirossian G,Hnatowich DJ

更新日期：1996-10-01 00:00:00

abstract：:[11C]Methamphetamine, a psychotropic agent, was synthesized by N-methylation of amphetamine with [11C]CH3 I in hopes that it could be applied in the near future to assist positron emission tomography (PET) in the imaging of its distribution in the human brain. The regional distribution of [11C]methamphetamine was inve...

journal_title：Nuclear medicine and biology

authors： Mizugaki M,Hishinuma T,Nakamura H,Yamashita M,Shimomura K,Itoh K,Hirose A,Tomioka Y,Aso H,Edo K

更新日期：1993-05-01 00:00:00

abstract：:A simple method is described for affinity purification of radiolabeled antibodies using glutaraldehyde-fixed tumor target cells. The cell-bound antibody fraction is removed from the cells by an acid wash and then immediately subjected to buffer-exchange chromatography. The method was applied to the D3 murine monoclona...

journal_title：Nuclear medicine and biology

authors： Juweid M,Sato J,Paik C,Onay-Basaran S,Weinstein JN,Neumann RD

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:Herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene in combination with radiolabeled nucleoside substrates is the most widely used reporter system. This study characterized 1-(2'-deoxy-2'-[(18)F]fluoro-β-D-arabinofuranosyl)-5-iodocytosine ((18)F-FIAC) as a new potential positron emission tomography (P...

journal_title：Nuclear medicine and biology

authors： Chan PC,Wu CY,Chang WY,Chang WT,Alauddin M,Liu RS,Lin WJ,Chen FD,Chen CL,Wang HE

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Dysregulation of the hepatocyte growth factor (HGF)/MET pathway has been implicated in various cancers. Rilotumumab is an investigational, fully human monoclonal antibody that binds and neutralizes HGF. The purpose of this study was to evaluate the efficacy of rilotumumab in a U-87 MG mouse xenograft tumor...

journal_title：Nuclear medicine and biology

authors： Rex K,Lewis XZ,Gobalakrishnan S,Glaus C,Silva MD,Radinsky R,Burgess TL,Gambhir SS,Coxon A

更新日期：2013-05-01 00:00:00

abstract：:Radiolabeled lipiodol has been used for targeting liver cancer. We developed a lipiodol solution of (188)Re-TDD (2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol) and investigated its feasibility for the treatment of liver cancer. The lipiodol solution of (188)Re-TDD was well-retained in the lipiodol phase in vitro. A...

journal_title：Nuclear medicine and biology

authors： Jeong JM,Kim YJ,Lee YS,Ko JI,Son M,Lee DS,Chung JK,Park JH,Lee MC

更新日期：2001-02-01 00:00:00

abstract：:An in vivo estimation of the newly synthesized MAO-A specific inhibitor, [125I]-labeled N-[3(2,4-dichloro-6-iodophenoxy)propyl]-N-methyl-2- propynylamine ([125I]-iodoclorgyline), was performed. Retention of the radioactivity of this radioligand was observed in the brain from 1 h post-injection. Pretreatments with clor...

journal_title：Nuclear medicine and biology

authors： Hirata M,Magata Y,Ohmomo Y,Saji H,Murakami K,Takagaki T,Yamamura N,Tanaka C,Konishi J,Yokoyama A

更新日期：1995-02-01 00:00:00

abstract：:In the last few years click chemistry reactions, and in particular copper-catalyzed cycloadditions have been used extensively for the preparation of new bioconjugated molecules such as (18)F-radiolabeled radiopharmaceuticals for positron emission tomography (PET). This study is focused on the synthesis of the Siemens ...

journal_title：Nuclear medicine and biology

authors： Mirfeizi L,Walsh J,Kolb H,Campbell-Verduyn L,Dierckx RA,Feringa BL,Elsinga PH,de Groot T,Sannen I,Bormans G,Celen S

更新日期：2013-07-01 00:00:00

abstract：:The chemokine receptor CXCR4 is highly expressed in tumor cells and plays an important role in tumor metastasis. The aim of this study was to develop a radiopharmaceutical for the imaging of CXCR4-expressing tumors in vivo. Based on structure-activity relationships, we designed a 14-residue peptidic CXCR4 inhibitor, A...

journal_title：Nuclear medicine and biology

authors： Hanaoka H,Mukai T,Tamamura H,Mori T,Ishino S,Ogawa K,Iida Y,Doi R,Fujii N,Saji H

更新日期：2006-05-01 00:00:00

abstract：:The premise that, over the course of Alzheimer's disease (AD), changes in the levels of the vesicular acetylcholine transporter (VAChT) occur in parallel with changes to other cholinergic marker proteins provides the basis for the applicability of benzovesamicol derivatives as radioligands for AD studies by single pho...

journal_title：Nuclear medicine and biology

authors： Emond P,Mavel S,Zea-Ponce Y,Kassiou M,Garreau L,Bodard S,Drossard ML,Chalon S,Guilloteau D

更新日期：2007-11-01 00:00:00

abstract：:Dual probe microdialysis was employed in intact rat brain to investigate the effect of intrastriatal perfusion with selective dopamine D1 and D2 receptor agonists and with c-fos antisense oligonucleotide on (a) local GABA release in the striatum; (b) the internal segment of the globus pallidus and the substantia nigra...

journal_title：Nuclear medicine and biology

authors： O'Connor WT

更新日期：1998-11-01 00:00:00

abstract：INTRODUCTION:3'-Deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) shows great potential as a tracer for proliferative studies with PET. However, its regular application is often limited by low radiochemical yields and the use of a troublesome HPLC separation. Moreover, a high content of ethanol, at least one-fold higher tha...

journal_title：Nuclear medicine and biology

authors： Pascali C,Bogni A,Fugazza L,Cucchi C,Crispu O,Laera L,Iwata R,Maiocchi G,Crippa F,Bombardieri E

更新日期：2012-05-01 00:00:00

abstract：:The pituitary gonadotropins FSH and LH are secreted into blood as dimeric glycoproteins which display a wide heterogeneity when submitted to technique of separation based on electric charge. That supports the assumption of a major role of the carbohydrates moieties as a source of heterogeneity. No clear difference how...

journal_title：Nuclear medicine and biology

authors： Roger M,Lalhou N

更新日期：1994-04-01 00:00:00