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Evaluation of radioiodinated iodoclorgyline as a SPECT radiopharmaceutical for MAO-A in the brain.

Abstract：

:An in vivo estimation of the newly synthesized MAO-A specific inhibitor, [125I]-labeled N-[3(2,4-dichloro-6-iodophenoxy)propyl]-N-methyl-2- propynylamine ([125I]-iodoclorgyline), was performed. Retention of the radioactivity of this radioligand was observed in the brain from 1 h post-injection. Pretreatments with clorgyline and l-deprenyl showed selective binding of [125I]-iodoclorgyline to MAO-A in the brain at 24 h post-injection. Moreover, a good correlation (r = 0.907) between the uptake of [125I]-iodoclorgyline and MAO-A enzyme activity in the cortex was observed in the pretreatment study with several doses of clorgyline. Although improvement to increase the brain/blood ratio is desirable because of slow blood clearance of the radioactivity, radioiodinated iodoclorgyline may serve as a useful SPECT radiopharmaceutical for quantitative analysis of MAO-A in the brain.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Hirata M,Magata Y,Ohmomo Y,Saji H,Murakami K,Takagaki T,Yamamura N,Tanaka C,Konishi J,Yokoyama A

doi

10.1016/0969-8051(94)00105-s

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

175-80

issue

2

eissn

0969-8051

issn

1872-9614

pii

096980519400105S

journal_volume

22

pub_type

杂志文章

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