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Functional comparison of annexin V analogues labeled indirectly and directly with iodine-124.

Abstract：

:We are interested in imaging cell death in vivo using annexin V radiolabeled with (124)I. In this study, [(124)I]4IB-annexin V and [(124)I]4IB-ovalbumin were made using [(124)I]N-hydroxysuccinimidyl-4-iodobenzoate prepared by iododestannylation of N-hydroxysuccinimidyl-4-(tributylstannyl)benzoate. [(124)I]4IB-annexin V binds to phosphatidylserine-coated microtiter plates and apoptotic Jurkat cells and accumulates in hepatic apoptotic lesions in mice treated with anti-Fas antibody, while [(124)I]4IB-ovalbumin does not. In comparison with (124)I-annexin V, [(124)I]4IB-annexin V has a higher rate of binding to phosphatidylserine in vitro, a higher kidney and urine uptake, a lower thyroid and stomach content uptake, greater plasma stability and a lower rate of plasma clearance. Binding of radioactivity to apoptotic cells relative to normal cells in vitro and in vivo appears to be lower for [(124)I]4IB-annexin V than for (124)I-annexin V.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Dekker B,Keen H,Shaw D,Disley L,Hastings D,Hadfield J,Reader A,Allan D,Julyan P,Watson A,Zweit J

doi

10.1016/j.nucmedbio.2005.02.002

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

403-13

issue

4

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(05)00052-1

journal_volume

32

pub_type

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