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Fluorine-18-labelled NCQ 115, a selective dopamine D-2 receptor ligand. Preparation and positron emission tomography.

Abstract：

:NCQ 115 ((+)-(R)-5-bromo-N-((1-(4-fluorobenzyl)-2-pyrrolidinyl)methyl)-2, 3-dimethoxybenzamide) is a selective dopamine D-2 receptor antagonist. NCQ 115 has a fluorine in a synthetically suitable position in the parent compound and was therefore suggested as a potential 18F-labelled radioligand for positron emission tomography (PET). [18F]4-Fluorobenzyl iodide was prepared in a 3-step synthesis from [18F]fluoride. N-4-Fluorobenzylation of the corresponding secondary pyrrolidine precursor was performed in DMF followed by purification with semi-preparative HPLC. The total radiochemical yield (EOB and decay-corrected) was 15-20% with a total synthesis time of 90 min and a radiochemical purity > 99%. The specific radioactivity at the end of synthesis (EOS) was about 1500 Ci/mmol (55.5 GBq/mumol). [18F]NCQ 115 was injected into a Cynomolgus monkey for PET examination of brain in vivo. There was a conspicuous uptake of radioactivity in the monkey striatum. A specific [18F]NCQ 115 binding reached a peak after about 60 min which indicates equilibrium.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Halldin C,Högberg T,Farde L

doi

10.1016/0969-8051(94)90028-0

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

627-31

issue

4

eissn

0969-8051

issn

1872-9614

pii

0969-8051(94)90028-0

journal_volume

21

pub_type

杂志文章

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