Effect of arteriovenous difference in measuring renal function by single-injection plasma clearance: role of bolus.

abstract：:In this study we demonstrated that significant egress of FDG from myocardium occurs within the first hour after tracer injection leading to nonlinear Patlak plots. There are also significant amounts of acidic FDG metabolites present in the blood. However, the impact of these metabolites on the estimates of myocardial ...

journal_title：Nuclear medicine and biology

authors： Herrero P,Dence CS,Sharp TL,Welch MJ,Gropler RJ

更新日期：2004-10-01 00:00:00

abstract：:188Re-perrhenate has been reported effective in preventing restenosis after percutaneous transluminal coronary angioplasty. However, if the balloon ruptures, 188Re-perrhenate is released into the circulation, causing high radiation dosing to the thyroid and stomach. In this study, we evaluated the effects of perchlora...

journal_title：Nuclear medicine and biology

authors： Lin WY,Hsieh JF,Tsai SC,Yen TC,Wang SJ,Knapp FF Jr

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:The identification of sentinel lymph nodes (SLNs) is important in deciding the resection range during surgery. 99mTc-labeled mannosylated human serum albumin ([99mTc]Tc-MSA) is a radiopharmaceutical developed for SLN detection by targeting macrophages. Evans blue (EB) is a blue dye binding strongly to albu...

journal_title：Nuclear medicine and biology

authors： Lee JY,Kim HY,Lee YS,Seo HY,Park JY,Jeong JM

更新日期：2020-01-01 00:00:00

abstract：:The advent of antibody-based cancer therapeutics has led to the concomitant rise in the development of companion diagnostics for these therapies, particularly nuclear imaging agents. A number of radioisotopes have been employed for antibody-based PET and SPECT imaging, notably ⁶⁴Cu, ¹²⁴I, ¹¹¹In, and (99m)Tc; in recent...

journal_title：Nuclear medicine and biology

authors： Deri MA,Zeglis BM,Francesconi LC,Lewis JS

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Thymidylate synthase and folate receptors are well-developed targets of cancer therapy. Discovery of a simple and fast method for the conversion of 11CH3Ito[11C]-formaldehyde (11CH2O) encouraged us to label the co-factor of this enzyme. Preliminary studies conducted on cell lines have demonstrated a prefer...

journal_title：Nuclear medicine and biology

authors： Saeed M,Tewson TJ,Erdahl CE,Kohen A

更新日期：2012-07-01 00:00:00

abstract：:Matrix metalloproteinase-2 (MMP-2) is a key enzyme involved in tumor invasiveness. (2R)-2- [4-(6-[(18)F]Fluorohex-1-ynyl)-benzenesulfonylamino]-3-methylbutyric acid ([(18)F]SAV03), a new fluorine-18 labeled MMP-2 inhibitor developed for tumor imaging with PET, was biologically evaluated using in vivo tumor model. Enzy...

journal_title：Nuclear medicine and biology

authors： Furumoto S,Takashima K,Kubota K,Ido T,Iwata R,Fukuda H

更新日期：2003-02-01 00:00:00

abstract：:Positron emission tomography (PET) studies of cancer with the glucose analog 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) have emerged as both a useful research and clinical method for detecting (diagnosing), staging, and monitoring treatment responses in a variety of neoplasms, including tumors of the brain, head and neck,...

journal_title：Nuclear medicine and biology

authors： Hawkins RA,Hoh CK

更新日期：1994-07-01 00:00:00

abstract：:Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. [(166)Dy]Dy/(166)Ho-ethylenediaminetetramethylene phosphonate (EDTMP) forms a stable in vivo generator system with selective skeletal uptake in mice; therefore, i...

journal_title：Nuclear medicine and biology

authors： Pedraza-López M,Ferro-Flores G,Arteaga de Murphy C,Morales-Ramírez P,Piedras-Ross J,Murphy-Stack E,Hernández-Oviedo O

更新日期：2004-11-01 00:00:00

abstract：:The present study was undertaken to investigate if pretreatment with pharmacological agents could change the organ uptake of 11C-labelled L-DOPA, and especially if the urinary excretion could be decreased. L-[beta-11C]DOPA was injected IV into unanesthetized Sprague-Dawley rats. After 20 min the rats were decapitated ...

journal_title：Nuclear medicine and biology

authors： Bergström M,Lu L,Marquez M,Fasth KJ,Bjurling P,Watanabe Y,Eriksson B,Långström B

更新日期：1997-01-01 00:00:00

abstract：:The gastrin releasing peptide (GRP) receptor is becoming an increasingly attractive target for development of new radiolabeled peptides with diagnostic and therapeutic potential. The attractiveness of the GRP receptor as a target is based upon the functional expression of GRP receptors in several tumors of neuroendocr...

journal_title：Nuclear medicine and biology

authors： Smith CJ,Volkert WA,Hoffman TJ

更新日期：2003-11-01 00:00:00

abstract：:NCQ 115 ((+)-(R)-5-bromo-N-((1-(4-fluorobenzyl)-2-pyrrolidinyl)methyl)-2, 3-dimethoxybenzamide) is a selective dopamine D-2 receptor antagonist. NCQ 115 has a fluorine in a synthetically suitable position in the parent compound and was therefore suggested as a potential 18F-labelled radioligand for positron emission t...

journal_title：Nuclear medicine and biology

authors： Halldin C,Högberg T,Farde L

更新日期：1994-05-01 00:00:00

abstract：:The Cu(I)-assisted aromatic halogen exchange proved useful for preparation of macroscopic amounts of 2-iodophenyl-metyrapone as well as for the n.c.a. radioiodinated analogue. Semi-preparative HPLC-isolation provided the compound with high purity for use as chromatographic standard and for the determination of the inh...

journal_title：Nuclear medicine and biology

authors： Schirbel A,Coenen HH

更新日期：1995-11-01 00:00:00

abstract：INTRODUCTION:The heavy halogen (211)At is of great interest for targeted radiotherapy because it decays by the emission of short-range, high-energy α-particles. However, many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking other (211)At labeling strategies. One relat...

journal_title：Nuclear medicine and biology

authors： Pruszyński M,Łyczko M,Bilewicz A,Zalutsky MR

更新日期：2015-05-01 00:00:00

abstract：:6-Hydrazinopyridine-3-carboxylic acid (HYNIC) is a representative agent used to prepare technetium-99m ((99m)Tc)-labeled polypeptides with tricine as a coligand. However, (99m)Tc-HYNIC-labeled polypeptides show delayed elimination rates of the radioactivity not only from the blood but also from nontarget tissues such ...

journal_title：Nuclear medicine and biology

authors： Ono M,Arano Y,Mukai T,Fujioka Y,Ogawa K,Uehara T,Saga T,Konishi J,Saji H

更新日期：2001-04-01 00:00:00

abstract：:Cocaine was initially labeled with carbon-11 in order to track the distribution and pharmacokinetics of this powerful stimulant and drug of abuse in the human brain and body. It was soon discovered that [(11)C]cocaine was not only useful for measuring cocaine pharmacokinetics and its relationship to behavior but that ...

journal_title：Nuclear medicine and biology

authors： Fowler JS,Volkow ND,Wang GJ,Gatley SJ,Logan J

更新日期：2001-07-01 00:00:00

abstract：INTRODUCTION:Nuclear and optical imaging are complementary in many aspects and there would be many advantages when optical imaging probes are prepared using radionuclides rather than classic fluorophores, and when nuclear and optical dual images are obtained using single imaging probe. METHODS:The luminescence intensi...

journal_title：Nuclear medicine and biology

authors： Park JC,Il An G,Park SI,Oh J,Kim HJ,Su Ha Y,Wang EK,Min Kim K,Kim JY,Lee J,Welch MJ,Yoo J

更新日期：2011-04-01 00:00:00

abstract：:We have synthesized three different PET ligands to investigate the physiological function of metabotropic glutamate subtype 5 receptors (mGluR5) in vivo: 2-[(11)C]methyl-6-(2-phenylethynyl)pyridine ([(11)C]MPEP), 2-(2-(3-[(11)C]methoxyphenyl)ethynyl)pyridine ([(11)C]M-MPEP) and 2-(2-(5-[(11)C]methoxypyridin-3-yl)ethyn...

journal_title：Nuclear medicine and biology

authors： Yu M,Tueckmantel W,Wang X,Zhu A,Kozikowski AP,Brownell AL

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:The cellular binding and processing of an epidermal growth factor receptor (EGFR) targeting affibody molecule, (Z(EGFR:955))(2), was studied. This new and small molecule is aimed for applications in nuclear medicine. The natural ligand epidermal growth factor (EGF) and the antibody cetuximab were studied f...

journal_title：Nuclear medicine and biology

authors： Nordberg E,Friedman M,Göstring L,Adams GP,Brismar H,Nilsson FY,Ståhl S,Glimelius B,Carlsson J

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION:Hypoxia plays a negative role in the clinical management of cancer. Detection of hypoxic status of a cancer is important for selecting patients for hypoxia directed therapy. Though [(18)F]fluoromisonidazole ([(18)F]FMISO), a PET radiopharmaceutical, is presently being used in the clinic for the detection o...

journal_title：Nuclear medicine and biology

authors： Mallia MB,Subramanian S,Mathur A,Sarma HD,Banerjee S

更新日期：2014-08-01 00:00:00

abstract：:The uptake, retention and tissue to blood ratios of two non-steroidal, 125I-labeled iodoestrogens, an iodotrihydroxyphenylethylene, 2-iodo-1,2-bis(4-hydroxyphenyl)-2-(3-hydroxyphenyl)ethylene and an iododihydroxyphenylethylene, 2-iodo-1,1-bis(4-hydroxyphenyl)-2-phenylethylene, were compared after intraperitoneal injec...

journal_title：Nuclear medicine and biology

authors： Desombre ER,Pribish J,Hughes A

更新日期：1995-07-01 00:00:00

abstract：:In the quantitative studies of presynaptic dopamine metabolism by PET with 6-[18F]fluoro-L-dopa (6-[18F]FDOPA), metabolic analysis in the plasma is required to determine the precise input function because of susceptibility of the compound to peripheral metabolism. In this study, we prepared 6-[18F]-fluoro-O-pivaloyl-L...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Shinoda M,Ishii S,Nozaki T,Senda M

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVES:Positron emission tomography (PET) using O-(2-[(18)F]fluoroethyl)-l-tyrosine (FET) has been successfully employed in the diagnostic workup of brain tumors. Knowledge on the mechanisms of the uptake of radiolabeled amino acids into thyroidal tissues and well-differentiated thyroid carcinomas is limited. We th...

journal_title：Nuclear medicine and biology

authors： Prante O,Bläser D,Maschauer S,Kuwert T

更新日期：2007-04-01 00:00:00

abstract：:Antimicrobial peptides have been proposed as new agents to distinguish between bacterial infections and sterile inflammatory processes. (99m)Tc-UBI labeled by a direct method has shown high in vitro and in vivo stability, specific uptake at the site of infection, rapid background clearance, minimal accumulation in non...

journal_title：Nuclear medicine and biology

authors： Meléndez-Alafort L,Rodríguez-Cortés J,Ferro-Flores G,Arteaga De Murphy C,Herrera-Rodríguez R,Mitsoura E,Martínez-Duncker C

更新日期：2004-04-01 00:00:00

abstract：:The aim of this work was to develop a method to produce 18F-labeled fluorine gas ([18F]F2) with high specific radioactivity (SA, radioactivity/mass-ratio). 18F-Labeled methyl fluoride ([18F]CH3F) was synthesized from [18F]F-aq and mixed with carrier F2 in an inert neon matrix. The constituents were atomized in an elec...

journal_title：Nuclear medicine and biology

authors： Bergman J,Solin O

更新日期：1997-10-01 00:00:00

abstract：:Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [18O]O2. A method for the routine production of clinically useful quantities of [18F]F2 having a specific activity of 35 Ci/mmol has been developed...

journal_title：Nuclear medicine and biology

authors： Chirakal R,Adams RM,Firnau G,Schrobilgen GJ,Coates G,Garnett ES

更新日期：1995-01-01 00:00:00

abstract：:The chemokine receptor CXCR4 is highly expressed in tumor cells and plays an important role in tumor metastasis. The aim of this study was to develop a radiopharmaceutical for the imaging of CXCR4-expressing tumors in vivo. Based on structure-activity relationships, we designed a 14-residue peptidic CXCR4 inhibitor, A...

journal_title：Nuclear medicine and biology

authors： Hanaoka H,Mukai T,Tamamura H,Mori T,Ishino S,Ogawa K,Iida Y,Doi R,Fujii N,Saji H

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene in combination with radiolabeled nucleoside substrates is the most widely used reporter system. This study characterized 1-(2'-deoxy-2'-[(18)F]fluoro-β-D-arabinofuranosyl)-5-iodocytosine ((18)F-FIAC) as a new potential positron emission tomography (P...

journal_title：Nuclear medicine and biology

authors： Chan PC,Wu CY,Chang WY,Chang WT,Alauddin M,Liu RS,Lin WJ,Chen FD,Chen CL,Wang HE

更新日期：2011-10-01 00:00:00

abstract：UNLABELLED:In recent years, several PET and SPECT studies have shown loss of striatal dopamine transporter (DAT) binding in amphetamine (AMPH) users. However, the use of DAT SPECT tracers to detect AMPH-induced changes in DAT binding has not been validated. We therefore examined if repeated administration of D-AMPH or ...

journal_title：Nuclear medicine and biology

authors： Booij J,de Bruin K,Gunning WB

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:Gonadotropin releasing hormone (GnRH) receptor is overexpressed in many human tumors. Previously we developed a 18F-labelled GnRH peptide. Although the GnRH-targeted PET probe can be clearly visualized by microPET imaging in a PC-3 xenograft model, clinical applications of the probe have been limited by co...

journal_title：Nuclear medicine and biology

authors： Huang S,Wu H,Li B,Fu L,Sun P,Wang M,Hu K

更新日期：2020-01-01 00:00:00

abstract：:Synthesis and preliminary biological evaluation of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl)-guanine ([18F]FHBG) is reported. 9-(4-Hydroxy-3-hydroxymethylbutyl)-guanine (penciclovir) 4 was converted to 9-[N2, O-bis-(methoxytrityl)-3-(tosylmethybutyl)]guanine 7 by treatment with methoxytrityl chloride followed by tosylat...

journal_title：Nuclear medicine and biology

authors： Alauddin MM,Conti PS

更新日期：1998-04-01 00:00:00