Positron emission tomography in drug evaluation: influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-L-dopa in rhesus monkey.

abstract：:The anti-human epidermal growth factor receptor (EGF-R) humanized antibody h-R3 (IgG(1)), which binds to an extracellular domain of EGF-R, was used to evaluate the biodistribution on nude mice xenografted with A431 epidermoid carcinoma cell line. Results are compared with its murine version ior egf/r3 monoclonal antib...

journal_title：Nuclear medicine and biology

authors： Morales AA,Ducongé J,Alvarez-Ruiz D,Becquer-Viart ML,Núñez-Gandolff G,Fernández E,Caballero-Torres I,Iznaga-Escobar N

更新日期：2000-02-01 00:00:00

abstract：:Radiolabeled lipiodol has been used for targeting liver cancer. We developed a lipiodol solution of (188)Re-TDD (2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol) and investigated its feasibility for the treatment of liver cancer. The lipiodol solution of (188)Re-TDD was well-retained in the lipiodol phase in vitro. A...

journal_title：Nuclear medicine and biology

authors： Jeong JM,Kim YJ,Lee YS,Ko JI,Son M,Lee DS,Chung JK,Park JH,Lee MC

更新日期：2001-02-01 00:00:00

abstract：UNLABELLED:Gastrin-releasing peptide receptors (GRPr) are a member of the bombesin (BBN) receptor family. GRPr are expressed in high numbers on specific human cancers, including human prostate cancer. Therefore, copper-64 ((64)Cu) radiolabeled BBN(7-14)NH(2) conjugates could have potential for diagnosis of human prosta...

journal_title：Nuclear medicine and biology

authors： Lane SR,Nanda P,Rold TL,Sieckman GL,Figueroa SD,Hoffman TJ,Jurisson SS,Smith CJ

更新日期：2010-10-01 00:00:00

abstract：:111In-LDTPA galactose BSA (bovine serum albumin) was used to evaluate the asialoglycoprotein receptor (ASGPR) system in both normal and ASGPR-deficient mice. The radiolabeled glycoprotein had complete liver uptake in both normal and ASGPR-deficient mice. Metabolism and hepatic cell-type distribution studies were perfo...

journal_title：Nuclear medicine and biology

authors： Deal KA,Cristel ME,Welch MJ

更新日期：1998-05-01 00:00:00

abstract：:Fluorine-18 labeled 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nort ropane (FECNT) was synthesized in the development of a dopamine transporter (DAT) imaging ligand for positron emission tomography (PET). The methods of radiolabeling and ligand synthesis of FECNT, and the results of the in vitro charac...

journal_title：Nuclear medicine and biology

authors： Goodman MM,Kilts CD,Keil R,Shi B,Martarello L,Xing D,Votaw J,Ely TD,Lambert P,Owens MJ,Camp VM,Malveaux E,Hoffman JM

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Radiolabeled 2-nitroimidazoles (azomycins) are a prominent class of biomarkers for PET imaging of hypoxia. [18F]Fluoro-azomycin-α-arabinoside ([18F]FAZA) - already in clinical use - may be seen as α-configuration nucleoside, but enters cells only via diffusion and is not transported by cellular nucleoside ...

journal_title：Nuclear medicine and biology

authors： Schweifer A,Maier F,Ehrlichmann W,Lamparter D,Kneilling M,Pichler BJ,Hammerschmidt F,Reischl G

更新日期：2016-12-01 00:00:00

abstract：:The radiolabelled amino acid 3-[(123)I]iodo-L-alpha-methyl tyrosine ([(123)I]IMT) is a promising tool for the diagnosis and monitoring of brain tumors using single-photon emission tomography (SPECT). However, little is known about the precise kinetics of [(123)I]IMT uptake in human glioma cells. The kinetic analysis o...

journal_title：Nuclear medicine and biology

authors： Riemann B,Kopka K,Stögbauer F,Halfter H,Ketteler S,Phan TQ,Franzius C,Weckesser M,Ringelstein EB,Schober O

更新日期：2001-04-01 00:00:00

abstract：:In vivo pharmacokinetic and brain binding characteristics of [18F]RP 62203, a selective high-affinity serotonergic 5-HT2A receptor antagonist, were assessed in the rat following intravenous injection of trace amount of the radioligand. The radioactive distribution profile observed in the brain 60 min after injection w...

journal_title：Nuclear medicine and biology

authors： Besret L,Dauphin F,Huard C,Lasne MC,Vivet R,Mickala P,Barbelivien A,Baron JC

更新日期：1996-02-01 00:00:00

abstract：:We describe the synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ), which differs from the typically used [(18)F]fluoroethylflumazenil (FEFMZ) for benzodiazepine receptor imaging. For one-pot one-step labeling, the precursors, 2'-tosyloxyflumazenil (TFMZ) and 2'-mesyloxyflumazenil (MFMZ), were synthesized in three steps. ...

journal_title：Nuclear medicine and biology

authors： Yoon YH,Jeong JM,Kim HW,Hong SH,Lee YS,Kil HS,Chi DY,Lee DS,Chung JK,Lee MC

更新日期：2003-07-01 00:00:00

abstract：:HeLa S-3 cells were treated with 195mPt-radiolabeled trans-diaminedichloroplatinum(II) (TDDP) under various conditions, and the relationship between lethal effect and the number of Pt atoms binding to DNA, RNA and proteins was examined. The mean lethal concentrations for the cells treated with TDDP at 37 degrees C for...

journal_title：Nuclear medicine and biology

authors： Akaboshi M,Kawai K,Maki H,Akuta K,Ujeno Y,Ono K,Miyahara T

更新日期：1993-05-01 00:00:00

abstract：INTRODUCTION:Targeted α-radionuclide therapy has attracted attention as a promising therapy for refractory cancers. However, the application is limited to certain types of cancer. Since L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers, we prepared an LAT1-selective α-radionuclide-labe...

journal_title：Nuclear medicine and biology

authors： Ohshima Y,Suzuki H,Hanaoka H,Sasaki I,Watanabe S,Haba H,Arano Y,Tsushima Y,Ishioka NS

更新日期：2020-01-01 00:00:00

abstract：:meta-[18F]Fluorobenzylguanidine ([18F]MFBG) and para-[18F]fluorobenzylguanidine ([18F]PFBG) were synthesized in three steps beginning with a fluoro for nitro exchange reaction on 3- and 4-nitrobenzonitrile, respectively. Overall radiochemical yields were 10-15% for [18F]MFBG and 50-55% for [18F]PFBG in a total synthes...

journal_title：Nuclear medicine and biology

authors： Garg PK,Garg S,Zalutsky MR

更新日期：1994-01-01 00:00:00

abstract：:Asynchronous exponentially growing EL4 murine T lymphoma cells were exposed either to high LET alpha-radiation from 212Bi-DTPA or to gamma-radiation from a 137Cs source. Radiation-induced cell cycle perturbation was studied by flow cytometry. Alpha irradiation, like gamma, transiently arrested cells in the G2M phase i...

journal_title：Nuclear medicine and biology

authors： Palayoor ST,Humm JL,Atcher RW,Hines JJ,Macklis RM

更新日期：1993-08-01 00:00:00

abstract：:The discovery of neuroendocrine differentiation in hormone-refractory prostatic adenocarcinoma has opened a potentially new therapeutic approach in this group of patients with a poor prognosis and few effective therapy modalities. Based on previous findings of increased uptake of 11C-5-hydroxytryptophan (11C-5-HTP) in...

journal_title：Nuclear medicine and biology

authors： Kälkner KM,Ginman C,Nilsson S,Bergström M,Antoni G,Ahlström H,Långström B,Westlin JE

更新日期：1997-05-01 00:00:00

abstract：INTRODUCTION:Telmisartan, a nonpeptide angiotensin II AT1 receptor antagonist used as an antihypertensive drug, is specifically taken up by the liver through the OATP1B3. PET imaging with [(11)C]telmisartan is expected to provide information about the whole body pharmacokinetics of telmisartan as well as its transport ...

journal_title：Nuclear medicine and biology

authors： Shimizu K,Takashima T,Yamane T,Sasaki M,Kageyama H,Hashizume Y,Maeda K,Sugiyama Y,Watanabe Y,Senda M

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Earlier studies indicated that bevacizumab could favorably be combined with radiation. However excessive damage to tumor vasculature can result in radioresistance and clinical data suggest that treatment sequencing may be important when combining bevacizumab with radiation. The aim of this study was to eva...

journal_title：Nuclear medicine and biology

authors： Becker S,Bohn P,Bouyeure-Petit AC,Modzelewski R,Gensanne D,Picquenot JM,Dubray B,Vera P

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Cu-diacetyl-bis(N4-methylthiosemicarbazone) [Cu-ATSM], although excellent for oncology applications, may not be suitable for delineating cardiovascular or neurological hypoxia. For this reason, new Cu hypoxia positron emission tomography (PET) imaging agents are being examined to search for a higher selectiv...

journal_title：Nuclear medicine and biology

authors： McQuade P,Martin KE,Castle TC,Went MJ,Blower PJ,Welch MJ,Lewis JS

更新日期：2005-02-01 00:00:00

abstract：INTRODUCTION:Human epidermal growth factor receptor type 2 (HER2) overexpression supports proliferation of androgen-independent prostate cancer (PC). Radionuclide molecular imaging of HER2 expression in disseminated PC would aid in the selection of patients who are likely responders to HER2 targeting therapy. In this s...

journal_title：Nuclear medicine and biology

authors： Malmberg J,Sandström M,Wester K,Tolmachev V,Orlova A

更新日期：2011-11-01 00:00:00

abstract：:The premise that, over the course of Alzheimer's disease (AD), changes in the levels of the vesicular acetylcholine transporter (VAChT) occur in parallel with changes to other cholinergic marker proteins provides the basis for the applicability of benzovesamicol derivatives as radioligands for AD studies by single pho...

journal_title：Nuclear medicine and biology

authors： Emond P,Mavel S,Zea-Ponce Y,Kassiou M,Garreau L,Bodard S,Drossard ML,Chalon S,Guilloteau D

更新日期：2007-11-01 00:00:00

abstract：:We have previously performed quantitative kinetic modeling of [(123)I]CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 hea...

journal_title：Nuclear medicine and biology

authors： Bressan RA,Erlandsson K,Mulligan RS,Gunn RN,Cunningham VJ,Owens J,Cullum ID,Ell PJ,Pilowsky LS

更新日期：2004-02-01 00:00:00

abstract：:Dithiocarboxylate ligands were synthesized and characterised. New nitrido 99m-technetium complexes were obtained with these ligands and identified by thin layer chromatography. The nitrido complexes were tested in vitro in whole blood for leucocyte labelling and the design of the ligand was optimized. Best results wer...

journal_title：Nuclear medicine and biology

authors： Demaimay F,Noiret N,Roucoux A,Patin H,Bellande E,Pasqualini R,Moisan A

更新日期：1997-07-01 00:00:00

abstract：INTRODUCTION:Renal uptake of Tc-99m-MG3 involves organic anion transporter (OAT). Treatment with drugs showing OAT affinity might interfere with renal uptake of Tc-99m-MAG3, leading to misinterpretation in Tc-99m-MAG3. This study was conducted to discuss a possible drug interference with Tc-99m-MAG3 diagnosis on OAT si...

journal_title：Nuclear medicine and biology

authors： Takahara N,Saga T,Inubushi M,Kusuhara H,Seki C,Ito S,Oyama N,Yokoyama O,Sugiyama Y,Fujibayashi Y

更新日期：2013-07-01 00:00:00

abstract：INTRODUCTION:Altered lipid metabolism and subsequent changes in cellular lipid composition have been observed in prostate cancer cells, are associated with poor clinical outcome, and are promising targets for metabolic therapies. This study reports for the first time on the synthesis of a phospholipid radiotracer based...

journal_title：Nuclear medicine and biology

authors： Kwan KH,Burvenich IJG,Centenera MM,Goh YW,Rigopoulos A,Dehairs J,Swinnen JV,Raj GV,Hoy AJ,Butler LM,Scott AM,White JM,Ackermann U

更新日期：2020-11-28 00:00:00

abstract：OBJECTIVES:To compare the radiolabeling performance, stability, and practical efficacy of the chelators CHX-A″-DTPA and H4octapa with the therapeutic radiometal (90)Y. METHODS:The bifunctional chelators p-SCN-Bn-H4octapa and p-SCN-Bn-CHX-A″-DTPA were conjugated to the HER2-targeting antibody trastuzumab. The resulting...

journal_title：Nuclear medicine and biology

authors： Price EW,Edwards KJ,Carnazza KE,Carlin SD,Zeglis BM,Adam MJ,Orvig C,Lewis JS

更新日期：2016-09-01 00:00:00

abstract：:The present study was undertaken to investigate if pretreatment with pharmacological agents could change the organ uptake of 11C-labelled L-DOPA, and especially if the urinary excretion could be decreased. L-[beta-11C]DOPA was injected IV into unanesthetized Sprague-Dawley rats. After 20 min the rats were decapitated ...

journal_title：Nuclear medicine and biology

authors： Bergström M,Lu L,Marquez M,Fasth KJ,Bjurling P,Watanabe Y,Eriksson B,Långström B

更新日期：1997-01-01 00:00:00

abstract：:Liver accumulation of 99mTc-DL-homocysteine (99mTc-Hcy), which had been found to accumulate in several experimental tumors, was studied using experimental hepatitis models of rats. The distribution of this compound in liver of rats treated with CCl4 (25-100 microL/100 g body weight) was more than five times higher tha...

journal_title：Nuclear medicine and biology

authors： Takeda A,Okumura H,Okada S

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:We evaluated new (111)In-labeled amino acid derivatives, in which the amino acids are conjugated with1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetraacetic acid (DOTA), 1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (DO2A) or 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A). METHODS:DOTA-aminoalanine...

journal_title：Nuclear medicine and biology

authors： Lee JJ,Shetty D,Lee YS,Kim SE,Kim YJ,Hong MK,Son JY,Jeong JM

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Imaging of the serotonergic innervation of the brain using positron emission tomography (PET) with the serotonin transporter (SERT) ligand [11C] (+)McN5652 might be affected by serotonin in the synaptic cleft if there is relevant interaction between [11C] (+)McN5652 and serotonin at the SERT. The aim of th...

journal_title：Nuclear medicine and biology

authors： Hummerich R,Schulze O,Rädler T,Mikecz P,Reimold M,Brenner W,Clausen M,Schloss P,Buchert R

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:3'-Deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) shows great potential as a tracer for proliferative studies with PET. However, its regular application is often limited by low radiochemical yields and the use of a troublesome HPLC separation. Moreover, a high content of ethanol, at least one-fold higher tha...

journal_title：Nuclear medicine and biology

authors： Pascali C,Bogni A,Fugazza L,Cucchi C,Crispu O,Laera L,Iwata R,Maiocchi G,Crippa F,Bombardieri E

更新日期：2012-05-01 00:00:00

abstract：:A computer controlled [15O]H2O injection system has been designed for multiple bolus injections during PET cerebral blood flow studies. The system is housed in a lead safe, and radiation exposure to nearby personnel is low; we have measured rates of approx. 100 microSv/h (10 mR/h) during 2 min of [15O]H2O production a...

journal_title：Nuclear medicine and biology

authors： Palmer BM,Sajjad M,Rottenberg DA

更新日期：1995-02-01 00:00:00