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Cellular distribution of 111In-LDTPA galactose BSA in normal and asialoglycoprotein receptor-deficient mouse liver.

Abstract：

:111In-LDTPA galactose BSA (bovine serum albumin) was used to evaluate the asialoglycoprotein receptor (ASGPR) system in both normal and ASGPR-deficient mice. The radiolabeled glycoprotein had complete liver uptake in both normal and ASGPR-deficient mice. Metabolism and hepatic cell-type distribution studies were performed. The normal mouse excreted greater than 60% of the hepatic activity, while the ASGPR-deficient mouse excreted less than 40% of the hepatic activity. 111In-LDTPA galactose BSA was metabolized to 111In-LDTPA-L-lysine in both mouse types. Normal mice showed 70% of the radioactivity in the hepatocyte, whereas the homozygous ASGPR-deficient mouse had equal activity in the hepatocyte and the hepatic endothelial cell.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Deal KA,Cristel ME,Welch MJ

doi

10.1016/s0969-8051(97)00222-9

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

379-85

issue

4

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(97)00222-9

journal_volume

25

pub_type

杂志文章

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