当前位置： SCI文献检索 > NUCLEAR MEDICINE AND BIOLOGY期刊下所有文献 > Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum: comparison of [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone.

Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum: comparison of [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone.

Abstract：

:With [11C]raclopride,[11C]nemonapride and [11C]N-methylspiperone, degeneration of dopamine D2-like receptors in the unilaterally quinolinic acid-lesioned rats was evaluated by positron emission tomography (PET) and ex vivo and in vitro autoradiography. PET showed a decreased uptake of [11C]raclopride in the lesioned striatum, but an increased uptake of [11C]nemonapride and [11C]N-methylspiperone despite a decreased binding in vitro. Ex vivo autoradiography showed an increased accumulation of the three ligands in the cortical region overlying the injured striatum, probably enlarging PET signals. PET has the limited potential for evaluating the receptor degeneration in the present animal model.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Ishiwata K,Ogi N,Hayakawa N,Umegaki H,Nagaoka T,Oda K,Toyama H,Endo K,Tanaka A,Senda M

doi

10.1016/s0969-8051(01)00307-9

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

307-16

issue

3

eissn

0969-8051

issn

1872-9614

pii

S0969805101003079

journal_volume

29

pub_type

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