Quantitative ex vivo and in vitro receptor autoradiography using 11C-labeled ligands and an imaging plate: a study with a dopamine D2-like receptor ligand [11C]nemonapride.

abstract：INTRODUCTION:The functions of I₂-imidazoline receptors (I₂Rs) are unknown, but evidence exists for their involvement in various neuropsychiatric disorders. Although a few positron emission tomography (PET) I₂R ligands have been developed, of which [(11)C]FTIMD and [(11)C]BU99008 were evaluated as PET I₂R imaging ligand...

journal_title：Nuclear medicine and biology

authors： Kawamura K,Shimoda Y,Kumata K,Fujinaga M,Yui J,Yamasaki T,Xie L,Hatori A,Wakizaka H,Kurihara Y,Ogawa M,Nengaki N,Zhang MR

更新日期：2015-04-01 00:00:00

abstract：:A positron-emitter labeled radioligand for the glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor, [(11)C]L-703,717, was examined for its ability to penetrate the brain in animals by simultaneous use with drugs having high-affinity separate binding sites on human serum albumin. [(11)C]L-703,717 has poor ...

journal_title：Nuclear medicine and biology

authors： Haradahira T,Zhang M,Maeda J,Okauchi T,Kawabe K,Kida T,Suzuki K,Suhara1 T

更新日期：2000-05-01 00:00:00

abstract：INTRODUCTION:Amino acid based radiotracers target tumor cells through increased uptake by membrane-associated amino acid transport (AAT) systems. In the present study, four structurally related non-natural (18)F-labeled amino acids, (R)- and (S)-[(18)F]FAMP 1 and (R)- and (S)-[(18)F]MeFAMP 2 have been prepared and eval...

journal_title：Nuclear medicine and biology

authors： Yu W,McConathy J,Olson JJ,Goodman MM

更新日期：2015-01-01 00:00:00

abstract：:The Cu(I)-assisted aromatic halogen exchange proved useful for preparation of macroscopic amounts of 2-iodophenyl-metyrapone as well as for the n.c.a. radioiodinated analogue. Semi-preparative HPLC-isolation provided the compound with high purity for use as chromatographic standard and for the determination of the inh...

journal_title：Nuclear medicine and biology

authors： Schirbel A,Coenen HH

更新日期：1995-11-01 00:00:00

abstract：:An in vivo estimation of the newly synthesized MAO-A specific inhibitor, [125I]-labeled N-[3(2,4-dichloro-6-iodophenoxy)propyl]-N-methyl-2- propynylamine ([125I]-iodoclorgyline), was performed. Retention of the radioactivity of this radioligand was observed in the brain from 1 h post-injection. Pretreatments with clor...

journal_title：Nuclear medicine and biology

authors： Hirata M,Magata Y,Ohmomo Y,Saji H,Murakami K,Takagaki T,Yamamura N,Tanaka C,Konishi J,Yokoyama A

更新日期：1995-02-01 00:00:00

abstract：INTRODUCTION:Targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as(223)Ra, (225)Ra, and (225)Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during...

journal_title：Nuclear medicine and biology

authors： Rojas JV,Woodward JD,Chen N,Rondinone AJ,Castano CH,Mirzadeh S

更新日期：2015-07-01 00:00:00

abstract：:Fluorine-18 labeled analogs of 8-fluorooctanoic acid and its structurally modified derivatives with methyl or gem-dimethyl branching or with oxygen substitution at the C3 position were prepared using nucleophilic substitution of the tosylate precursors by [18F]fluoride ion, for evaluation as tracers for cerebral fatty...

journal_title：Nuclear medicine and biology

authors： Nagatsugi F,Sasaki S,Maeda M

更新日期：1994-08-01 00:00:00

abstract：:Porcine insulin was labeled with 99mTc by direct tin reduction. More than 95% labeling efficiency was obtained on paper chromatography in saline and methyl ethyl ketone. The stability of the labeled compound was confirmed by paper chromatography at 3 h post-labeling and by human serum albumin (HSA) challenge. PAGE pat...

journal_title：Nuclear medicine and biology

authors： Awasthi V,Gambhir S,Sewatkar AB

更新日期：1994-02-01 00:00:00

abstract：:3-Amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile, labeled with carbon-11 ([11C]-DASB), is a recently introduced radiotracer for imaging the serotonin transporter (SERT) by positron emission tomography (PET). A series of in vitro and in vivo experiments were performed to further characterise the properties...

journal_title：Nuclear medicine and biology

authors： Wilson AA,Ginovart N,Hussey D,Meyer J,Houle S

更新日期：2002-07-01 00:00:00

abstract：:The aim of this work was to develop a method to produce 18F-labeled fluorine gas ([18F]F2) with high specific radioactivity (SA, radioactivity/mass-ratio). 18F-Labeled methyl fluoride ([18F]CH3F) was synthesized from [18F]F-aq and mixed with carrier F2 in an inert neon matrix. The constituents were atomized in an elec...

journal_title：Nuclear medicine and biology

authors： Bergman J,Solin O

更新日期：1997-10-01 00:00:00

abstract：METHODS:Anesthetized pigs were studied with [(11)C]-labeled fatty acids (FAs) with carbon chain length ranging from 8 to 16 carbon atoms, during control conditions and during inhibition of carnitine-palmitoyl transferase I (CPT I) with oxfenicine. The myocardial uptake of [(11)C]-FAs from blood was measured together wi...

journal_title：Nuclear medicine and biology

authors： Angsten G,Valind S,Takalo R,Neu H,Meurling S,Långström B

更新日期：2005-07-01 00:00:00

abstract：:The premise that, over the course of Alzheimer's disease (AD), changes in the levels of the vesicular acetylcholine transporter (VAChT) occur in parallel with changes to other cholinergic marker proteins provides the basis for the applicability of benzovesamicol derivatives as radioligands for AD studies by single pho...

journal_title：Nuclear medicine and biology

authors： Emond P,Mavel S,Zea-Ponce Y,Kassiou M,Garreau L,Bodard S,Drossard ML,Chalon S,Guilloteau D

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:In previous in-vitro and ex-vivo studies we proved the specific uptake of (99m)Tc radiolabeled chondroitin sulfate (CS) in human articular cartilage. As a logical next step for the clinical use for imaging osteoarthritis we investigated in-vivo uptake of (99m)TcCS in dogs. PROCEDURES:The radiolabeling of CS Co...

journal_title：Nuclear medicine and biology

authors： Sobal G,Velusamy K,Kosik S,Menzel J,Hacker M,Pagitz M

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:The present article demonstrates a 'mix-and-use' approach for radiolabeling RGD peptide derivative with (68)Ga, which is easily adaptable in hospital radiopharmacy practice. The radiotracer thus formulated was successfully used for positron emission tomography (PET) imaging of breast cancer in human patien...

journal_title：Nuclear medicine and biology

authors： Chakraborty S,Chakravarty R,Vatsa R,Bhusari P,Sarma HD,Shukla J,Mittal BR,Dash A

更新日期：2016-01-01 00:00:00

abstract：:Antagonists of neurokinin receptors such as CP-643,051 are presently under investigation as potential antidepressants, but little is known about the brain uptake and distribution of these agents. We developed a method for the efficient N-[11C]methylation of CP-122,721, yielding the NK1 antagonist N-[11C]methyl CP-643,...

journal_title：Nuclear medicine and biology

authors： Bender D,Olsen AK,Marthi MK,Smith DF,Cumming P

更新日期：2004-08-01 00:00:00

abstract：:PET centers without particle accelerators make clinical PET widely available at reduced cost. For myocardial perfusion tracers, these satellite PET centers are limited to generator- produced 82Rb(+) and 62Cu[PTSM]. Their limitations motivate a search for transportable alternatives. In search of new tracers we have syn...

journal_title：Nuclear medicine and biology

authors： Studenov AR,Berridge MS

更新日期：2001-08-01 00:00:00

abstract：UNLABELLED:Several radiopharmaceuticals and imaging techniques are proposed for breast cancer imaging. Since limited data are available of the uptake of SPECT and PET radiopharmaceuticals in malignant breast tumors and their metastases the aim of this study was to compare the uptake values and to correlate these data w...

journal_title：Nuclear medicine and biology

authors： Palmedo H,Hensel J,Reinhardt M,Von Mallek D,Matthies A,Biersack HJ

更新日期：2002-11-01 00:00:00

abstract：:NCQ 115 ((+)-(R)-5-bromo-N-((1-(4-fluorobenzyl)-2-pyrrolidinyl)methyl)-2, 3-dimethoxybenzamide) is a selective dopamine D-2 receptor antagonist. NCQ 115 has a fluorine in a synthetically suitable position in the parent compound and was therefore suggested as a potential 18F-labelled radioligand for positron emission t...

journal_title：Nuclear medicine and biology

authors： Halldin C,Högberg T,Farde L

更新日期：1994-05-01 00:00:00

abstract：:A folate-receptor-targeting radiopharmaceutical, Ga(III)-deferoxamine-folate (Ga-DF-Folate), was radiolabeled with two positron-emitting isotopes of gallium, cyclotron-produced (66)Ga (9.5 hour half-life) and generator-produced (68)Ga (68 minute half-life). The [(66)Ga]Ga-DF-Folate was administered to athymic mice wit...

journal_title：Nuclear medicine and biology

authors： Mathias CJ,Lewis MR,Reichert DE,Laforest R,Sharp TL,Lewis JS,Yang ZF,Waters DJ,Snyder PW,Low PS,Welch MJ,Green MA

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:Currently, the reference method of brown adipose tissue (BAT) imaging is 18F-fluorodeoxyglucose positron emission tomography ([18F]FDG PET). BAT imaging by [18F]FDG PET requires additional stimulation process, which is inconvenient and hard to be standardized. The translocator protein 18 kDa (TSPO) PET has...

journal_title：Nuclear medicine and biology

authors： Oh C,Song IH,Lee W,Jeon M,Choi J,Baek S,Lee BC,Kim SE,Im HJ

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Dopamine D3 receptors are implicated in various neuropsychiatric diseases, drug abuse and alcoholism, but specific agents for D3 molecular imaging are lacking. We evaluated two in vitro selective fluorine-18-labeled radioligand candidates ([(18)F]5 and [(18)F]6) for positron emission tomography (PET) imagi...

journal_title：Nuclear medicine and biology

authors： Hocke C,Cumming P,Maschauer S,Kuwert T,Gmeiner P,Prante O

更新日期：2014-03-01 00:00:00

abstract：:Radiolabeled derivatives of WAY-100635 have been shown to be important for imaging in vivo because of their antagonist properties and their specificity for the 5-hydroxytryptamine(1A) (5-HT(1A)) receptor. Our goal is to prepare a series of radiofluorinated derivatives of WAY-100635 that, in the rat, range in pharmacok...

journal_title：Nuclear medicine and biology

authors： Lang L,Jagoda E,Schmall B,Sassaman M,Ma Y,Eckelman WC

更新日期：2000-07-01 00:00:00

abstract：:An iodinated analog of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide , a specific antagonist of the peripheral-type benzodiazepine receptor (omega 3), has been synthesized in three steps with an overall chemical yield of 40%. Both [123I]- and [125I]-Iodo-PK11195 have been synthesize...

journal_title：Nuclear medicine and biology

authors： Gildersleeve DL,Van Dort ME,Johnson JW,Sherman PS,Wieland DM

更新日期：1996-01-01 00:00:00

abstract：:Matrix metalloproteinase-2 (MMP-2) is a key enzyme involved in tumor invasiveness. (2R)-2- [4-(6-[(18)F]Fluorohex-1-ynyl)-benzenesulfonylamino]-3-methylbutyric acid ([(18)F]SAV03), a new fluorine-18 labeled MMP-2 inhibitor developed for tumor imaging with PET, was biologically evaluated using in vivo tumor model. Enzy...

journal_title：Nuclear medicine and biology

authors： Furumoto S,Takashima K,Kubota K,Ido T,Iwata R,Fukuda H

更新日期：2003-02-01 00:00:00

abstract：:We have previously performed quantitative kinetic modeling of [(123)I]CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 hea...

journal_title：Nuclear medicine and biology

authors： Bressan RA,Erlandsson K,Mulligan RS,Gunn RN,Cunningham VJ,Owens J,Cullum ID,Ell PJ,Pilowsky LS

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Hepatic stellate cell (HSC) activation, which is accompanied by increased expression of integrin αvβ3, is an important factor in liver fibrogenesis. Molecular imaging targeting the integrin αvβ3 could provide a non-invasive method for evaluating the expression and the function of the integrin αvβ3 on the acti...

journal_title：Nuclear medicine and biology

authors： Zhang X,Xin J,Shi Y,Xu W,Yu S,Yang Z,Liu C,Cao L,Guo Q

更新日期：2015-03-01 00:00:00

abstract：:We report herein the preparation and biological evaluation of two radioastatinated biotin conjugates, (3-[211At]astatobenzoyl)norbiotinamide and ((5-[211At]astato-3-pyridinyl)carbonyl)norbiotinamide. Both conjugates were stable in the presence of human serum and cerebrospinal fluid as well as murine serum, indicating ...

journal_title：Nuclear medicine and biology

authors： Foulon CF,Alston KL,Zalutsky MR

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:In vivo reporter genes can be powerful tools in supporting and ensuring the success of gene therapy. A careful and rational design of a reporter system is essential to realize a noninvasive in vivo reporter gene imaging system applicable for humans. We designed a new in vivo reporter gene imaging system that us...

journal_title：Nuclear medicine and biology

authors： Furukawa T,Lohith TG,Takamatsu S,Mori T,Tanaka T,Fujibayashi Y

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:3'-Deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) shows great potential as a tracer for proliferative studies with PET. However, its regular application is often limited by low radiochemical yields and the use of a troublesome HPLC separation. Moreover, a high content of ethanol, at least one-fold higher tha...

journal_title：Nuclear medicine and biology

authors： Pascali C,Bogni A,Fugazza L,Cucchi C,Crispu O,Laera L,Iwata R,Maiocchi G,Crippa F,Bombardieri E

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Human epidermal growth factor receptor type 2 (HER2) overexpression supports proliferation of androgen-independent prostate cancer (PC). Radionuclide molecular imaging of HER2 expression in disseminated PC would aid in the selection of patients who are likely responders to HER2 targeting therapy. In this s...

journal_title：Nuclear medicine and biology

authors： Malmberg J,Sandström M,Wester K,Tolmachev V,Orlova A

更新日期：2011-11-01 00:00:00