Fluorine-18-labeled fluorine gas for synthesis of tracer molecules.

abstract：OBJECTIVE:(99m)Tc-MDP (technetium-99(m)-labeled methylene diphosphonate) has been widely used as a radiopharmaceutical for bone scintigraphy in cases of metastatic bone disease. (177)Lu is presently considered as an excellent radionuclide for developing bone pain palliation agents. No study on preparing a complex of (1...

journal_title：Nuclear medicine and biology

authors： Abbasi IA

更新日期：2011-04-01 00:00:00

abstract：:To investigate possible changes in somatostatin receptor expression during treatment with high dose lanreotide, eight patients with neuroendocrine tumors were investigated by [(111)In-DTPA-D-Phe1]-octreotide scintigraphy before and during treatment. The spleen-to-background ratio decreased in all patients, whereas tum...

journal_title：Nuclear medicine and biology

authors： Janson ET,Kälkner KM,Eriksson B,Westlin JE,Oberg K

更新日期：1999-11-01 00:00:00

abstract：INTRODUCTION:Targeted α-radionuclide therapy has attracted attention as a promising therapy for refractory cancers. However, the application is limited to certain types of cancer. Since L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers, we prepared an LAT1-selective α-radionuclide-labe...

journal_title：Nuclear medicine and biology

authors： Ohshima Y,Suzuki H,Hanaoka H,Sasaki I,Watanabe S,Haba H,Arano Y,Tsushima Y,Ishioka NS

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Thymidylate synthase and folate receptors are well-developed targets of cancer therapy. Discovery of a simple and fast method for the conversion of 11CH3Ito[11C]-formaldehyde (11CH2O) encouraged us to label the co-factor of this enzyme. Preliminary studies conducted on cell lines have demonstrated a prefer...

journal_title：Nuclear medicine and biology

authors： Saeed M,Tewson TJ,Erdahl CE,Kohen A

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:Leukemia stem cells (LSCs) are believed to be responsible for initiating and propagating acute myeloid leukemia (AML) and for causing relapse after treatment. Radioimmunotherapy (RIT) targeting these cells may improve the treatment of AML, but is limited by the low density of target epitopes. Our objective...

journal_title：Nuclear medicine and biology

authors： Zereshkian A,Leyton JV,Cai Z,Bergstrom D,Weinfeld M,Reilly RM

更新日期：2014-05-01 00:00:00

abstract：:We report herein the preparation and biological evaluation of two radioastatinated biotin conjugates, (3-[211At]astatobenzoyl)norbiotinamide and ((5-[211At]astato-3-pyridinyl)carbonyl)norbiotinamide. Both conjugates were stable in the presence of human serum and cerebrospinal fluid as well as murine serum, indicating ...

journal_title：Nuclear medicine and biology

authors： Foulon CF,Alston KL,Zalutsky MR

更新日期：1998-02-01 00:00:00

abstract：:In this study we demonstrated that significant egress of FDG from myocardium occurs within the first hour after tracer injection leading to nonlinear Patlak plots. There are also significant amounts of acidic FDG metabolites present in the blood. However, the impact of these metabolites on the estimates of myocardial ...

journal_title：Nuclear medicine and biology

authors： Herrero P,Dence CS,Sharp TL,Welch MJ,Gropler RJ

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:To evaluate the effectiveness of PET in differentiating malignant from benign pancreatic cystic tumors. METHODS:Between 2009 and 2010, all patients with pancreatic cystic tumors who had PET, triple phase contrast computed tomography (CT) and endoscopic ultrasound (EUS) were reviewed. Clinicopathological cha...

journal_title：Nuclear medicine and biology

authors： Zhang Y,Frampton AE,Martin JL,Kyriakides C,Bong JJ,Habib NA,Vlavianos P,Jiao LR

更新日期：2012-10-01 00:00:00

abstract：:Ex vivo and in vitro autoradiography (ARG) with radioluminography is a useful technique to characterize newly developed 11C-labeled positron emission tomography (PET) tracers and to apply them to biological and pharmacological studies. In this report, we have described a method of evaluating the radioactivity distribu...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Ogi N,Tanaka A,Senda M

更新日期：1999-04-01 00:00:00

abstract：:In the past 10 years, significant progress has been made in using a technetium-99m dopamine transporter imaging agent, [99mTc]TRODAT, for routine clinical studies. Developing a molecular imaging agent from bench to the bedside is more than a simple scientific venture. Currently, Taiwan is the only place where [99mTc]T...

journal_title：Nuclear medicine and biology

authors： Kung HF,Kung MP,Wey SP,Lin KJ,Yen TC

更新日期：2007-10-01 00:00:00

abstract：:The properties of two prospective positron emission tomography (PET) ligands for the delta-opioid receptor, N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) were investigated. Both were antagonists in the mouse vas deferens, and showed high affinity and selectivity, 1.81...

journal_title：Nuclear medicine and biology

authors： Tyacke RJ,Robinson ES,Schnabel R,Lewis JW,Husbands SM,Nutt DJ,Hudson AL

更新日期：2002-05-01 00:00:00

abstract：INTRODUCTION:After its intravenous injection, [18F]fluorocholine is oxidized by choline-oxidase into its main plasma metabolite, [18F]fluorobetaine. If PET kinetic modeling quantification of [18F]fluorocholine uptake is intended, the plasma input time-activity-curve of the parent tracer must be obtained, i.e., the frac...

journal_title：Nuclear medicine and biology

authors： Villar M,Valiente M,Toscano M,Galmés M,González C,Ortiz M,Vega F,Oporto M,Bibiloni P,Chinchilla JL,Molina J,Ríos Á,Peña C,Rubí S

更新日期：2019-01-01 00:00:00

abstract：:We have identified the value of 18F-fallypride [(S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide], as a dopamine D-2 receptor radiotracer for the study of striatal and extrastriatal receptors. Fallypride exhibits high affinities for D-2 and D-3 subtypes and low affinity for D-4 (3...

journal_title：Nuclear medicine and biology

authors： Mukherjee J,Yang ZY,Brown T,Lew R,Wernick M,Ouyang X,Yasillo N,Chen CT,Mintzer R,Cooper M

更新日期：1999-07-01 00:00:00

abstract：:Deuteron-induced nuclear reactions for generation of no-carrier-added (NCA) Lu isotopes were investigated using the stacked-foil activation technique on natural Yb targets at energies up to Ed=18.18MeV. The decay curve of ¹⁷⁷Yb, the growth curve of the cumulative (direct and indirect) and the direct production of (177...

journal_title：Nuclear medicine and biology

authors： Manenti S,Bonardi ML,Gini L,Groppi F

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Prognostic markers for progression of polycystic kidney disease (PKD) are limited. We evaluated the potential of early para-[(18)F]fluorohippurate ([(18)F]PFH) positron emission tomography (PET) renography to predict future progression of PKD in Han:SPRD rats with slowly progressive autosomal dominant PKD....

journal_title：Nuclear medicine and biology

authors： Pathuri G,Hedrick AF,Awasthi V,Cowley BD Jr,Gali H

更新日期：2016-01-01 00:00:00

abstract：:Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [18O]O2. A method for the routine production of clinically useful quantities of [18F]F2 having a specific activity of 35 Ci/mmol has been developed...

journal_title：Nuclear medicine and biology

authors： Chirakal R,Adams RM,Firnau G,Schrobilgen GJ,Coates G,Garnett ES

更新日期：1995-01-01 00:00:00

abstract：:Cocaine was initially labeled with carbon-11 in order to track the distribution and pharmacokinetics of this powerful stimulant and drug of abuse in the human brain and body. It was soon discovered that [(11)C]cocaine was not only useful for measuring cocaine pharmacokinetics and its relationship to behavior but that ...

journal_title：Nuclear medicine and biology

authors： Fowler JS,Volkow ND,Wang GJ,Gatley SJ,Logan J

更新日期：2001-07-01 00:00:00

abstract：:Structural variations of the nicotinic acetylcholine receptor radioligand N-[(11)C]methyl-epibatidine were made to form (11)C-labeled N-methyl-norchloroepibatidine (N-methyl-NorchloroEPB) and N-methyl-2-(2-pyridyl)-7-azabicyclo[2.2.1]heptane (N-methyl-2PABH). Radiosyntheses were performed by methylation with high radi...

journal_title：Nuclear medicine and biology

authors： Spang JE,Patt JT,Westera G,Schubiger PA

更新日期：2000-04-01 00:00:00

abstract：:A recently developed pinhole high-resolution SPECT system was used to measure striatal to non-specific binding ratios in rats (n = 9), after injection of the dopamine transporter ligand (123)I-FP-CIT, and to assess its test/retest reproducibility. For co-alignment purposes, the rat brain was imaged on a 1.5 Tesla clin...

journal_title：Nuclear medicine and biology

authors： Booij J,de Bruin K,de Win MM,Lavini C,den Heeten GJ,Habraken JB

更新日期：2003-08-01 00:00:00

abstract：:[11C]Methamphetamine, a psychotropic agent, was synthesized by N-methylation of amphetamine with [11C]CH3 I in hopes that it could be applied in the near future to assist positron emission tomography (PET) in the imaging of its distribution in the human brain. The regional distribution of [11C]methamphetamine was inve...

journal_title：Nuclear medicine and biology

authors： Mizugaki M,Hishinuma T,Nakamura H,Yamashita M,Shimomura K,Itoh K,Hirose A,Tomioka Y,Aso H,Edo K

更新日期：1993-05-01 00:00:00

abstract：INTRODUCTION:VEGF receptors play a key role in angiogenesis and are important targets for several approved and many experimental drugs. Imaging of VEGF receptor expression in malignant tumors would provide important information, which can influence patient management. The aim of this study was the development of an eas...

journal_title：Nuclear medicine and biology

authors： Eder M,Krivoshein AV,Backer M,Backer JM,Haberkorn U,Eisenhut M

更新日期：2010-05-01 00:00:00

abstract：:Rhenium-186 (Re-186) hydroxyethylidene diphosphonate (HEDP) has been shown to localize in metastatic foci within bone in a manner similar to Tc-99m bone-seeking agents. Usually, in the preparation of diagnostic Tc-99m radiopharmaceuticals, the concentration of Tc is at trace level (10(-8) M). However, large amounts of...

journal_title：Nuclear medicine and biology

authors： Lin WY,Hsieh JF,Lin CP,Hsieh BT,Ting G,Wang SJ,Knapp FF Jr

更新日期：1999-05-01 00:00:00

abstract：:Macrophages are a major inflammatory cell type involved in the development and progression of many important chronic inflammatory diseases. We previously found that apolipoprotein E-deficient (Apoe(-/-)) mice with the C57BL/6 (B6) background develop type 2 diabetes mellitus (T2DM) and accelerated atherosclerosis when ...

journal_title：Nuclear medicine and biology

authors： Zhang Y,Kundu B,Zhong M,Huang T,Li J,Chordia MD,Chen MH,Pan D,He J,Shi W

更新日期：2015-04-01 00:00:00

abstract：:An iodinated analog of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide , a specific antagonist of the peripheral-type benzodiazepine receptor (omega 3), has been synthesized in three steps with an overall chemical yield of 40%. Both [123I]- and [125I]-Iodo-PK11195 have been synthesize...

journal_title：Nuclear medicine and biology

authors： Gildersleeve DL,Van Dort ME,Johnson JW,Sherman PS,Wieland DM

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:⁶⁸Ga-labeled RGD peptides in combination with PET allow non-invasive determination of α(v)β₃ integrin expression which is highly increased during tumor-induced angiogenesis. The aim of this study was to synthesize and evaluate two RGD peptides containing alternative chelating systems, namely [⁶⁸Ga]NS₃-RGD-...

journal_title：Nuclear medicine and biology

authors： Knetsch PA,Petrik M,Rangger C,Seidel G,Pietzsch HJ,Virgolini I,Decristoforo C,Haubner R

更新日期：2013-01-01 00:00:00

abstract：:The Cu(I)-assisted aromatic halogen exchange proved useful for preparation of macroscopic amounts of 2-iodophenyl-metyrapone as well as for the n.c.a. radioiodinated analogue. Semi-preparative HPLC-isolation provided the compound with high purity for use as chromatographic standard and for the determination of the inh...

journal_title：Nuclear medicine and biology

authors： Schirbel A,Coenen HH

更新日期：1995-11-01 00:00:00

abstract：:Mild hydrochloric acid was used to induce injury in the caudal section of one lung in each of 10 dogs. 99mTc-red blood cells were injected intravenously. Blood samples were drawn prior to sacrifice. Lung and blood samples were weighed, assayed for radioactivity and dried to constant weight. Assuming a uniform hematocr...

journal_title：Nuclear medicine and biology

authors： Chu RY,Sidhu N,Carlile P Jr

更新日期：1993-02-01 00:00:00

abstract：INTRODUCTION:Dopamine D3 receptors are implicated in various neuropsychiatric diseases, drug abuse and alcoholism, but specific agents for D3 molecular imaging are lacking. We evaluated two in vitro selective fluorine-18-labeled radioligand candidates ([(18)F]5 and [(18)F]6) for positron emission tomography (PET) imagi...

journal_title：Nuclear medicine and biology

authors： Hocke C,Cumming P,Maschauer S,Kuwert T,Gmeiner P,Prante O

更新日期：2014-03-01 00:00:00

abstract：:Antimicrobial peptides have been proposed as new agents to distinguish between bacterial infections and sterile inflammatory processes. (99m)Tc-UBI labeled by a direct method has shown high in vitro and in vivo stability, specific uptake at the site of infection, rapid background clearance, minimal accumulation in non...

journal_title：Nuclear medicine and biology

authors： Meléndez-Alafort L,Rodríguez-Cortés J,Ferro-Flores G,Arteaga De Murphy C,Herrera-Rodríguez R,Mitsoura E,Martínez-Duncker C

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:The present article demonstrates a 'mix-and-use' approach for radiolabeling RGD peptide derivative with (68)Ga, which is easily adaptable in hospital radiopharmacy practice. The radiotracer thus formulated was successfully used for positron emission tomography (PET) imaging of breast cancer in human patien...

journal_title：Nuclear medicine and biology

authors： Chakraborty S,Chakravarty R,Vatsa R,Bhusari P,Sarma HD,Shukla J,Mittal BR,Dash A

更新日期：2016-01-01 00:00:00