Tumor detection using 18F-labeled matrix metalloproteinase-2 inhibitor.

abstract：:The imaging of apoptosis represents an attractive diagnostic goal in the area of tumor therapy, degenerative diseases and organ transplantation. Since caspases play a key role during the early period of the intracellular signal cascade of cells undergoing apoptosis we considered benzyloxycarbonyl-Val-Ala-DL-Asp(O-meth...

journal_title：Nuclear medicine and biology

authors： Haberkorn U,Kinscherf R,Krammer PH,Mier W,Eisenhut M

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:(99m)Tc-MDP (technetium-99(m)-labeled methylene diphosphonate) has been widely used as a radiopharmaceutical for bone scintigraphy in cases of metastatic bone disease. (177)Lu is presently considered as an excellent radionuclide for developing bone pain palliation agents. No study on preparing a complex of (1...

journal_title：Nuclear medicine and biology

authors： Abbasi IA

更新日期：2011-04-01 00:00:00

abstract：:The anabolism of isotopically labeled amino acids was compared between the cerebrum and the cerebellum in conscious rat at three feeding conditions. After L-[2-18F]fluorophenylalanine and L-[2,6-3H]phenylalanine injections, the incorporation rate of both radioactivity into protein fraction showed no difference between...

journal_title：Nuclear medicine and biology

authors： Nakamichi H,Murakami M,Miura S,Kondoh Y,Mizusawa S,Ono Y

更新日期：1994-10-01 00:00:00

abstract：INTRODUCTION:The cellular binding and processing of an epidermal growth factor receptor (EGFR) targeting affibody molecule, (Z(EGFR:955))(2), was studied. This new and small molecule is aimed for applications in nuclear medicine. The natural ligand epidermal growth factor (EGF) and the antibody cetuximab were studied f...

journal_title：Nuclear medicine and biology

authors： Nordberg E,Friedman M,Göstring L,Adams GP,Brismar H,Nilsson FY,Ståhl S,Glimelius B,Carlsson J

更新日期：2007-08-01 00:00:00

abstract：UNLABELLED:In recent years, several PET and SPECT studies have shown loss of striatal dopamine transporter (DAT) binding in amphetamine (AMPH) users. However, the use of DAT SPECT tracers to detect AMPH-induced changes in DAT binding has not been validated. We therefore examined if repeated administration of D-AMPH or ...

journal_title：Nuclear medicine and biology

authors： Booij J,de Bruin K,Gunning WB

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:The norepinephrine analogue (11)C-meta-hydroxyephedrine (HED) has been used to interrogate sympathetic neuronal reuptake in cardiovascular disease. Application for longitudinal studies in small animal models of disease necessitates an understanding of test-retest variability. This study evaluated the repea...

journal_title：Nuclear medicine and biology

authors： Thackeray JT,Renaud JM,Kordos M,Klein R,Dekemp RA,Beanlands RS,DaSilva JN

更新日期：2013-07-01 00:00:00

abstract：:188Re-perrhenate has been reported effective in preventing restenosis after percutaneous transluminal coronary angioplasty. However, if the balloon ruptures, 188Re-perrhenate is released into the circulation, causing high radiation dosing to the thyroid and stomach. In this study, we evaluated the effects of perchlora...

journal_title：Nuclear medicine and biology

authors： Lin WY,Hsieh JF,Tsai SC,Yen TC,Wang SJ,Knapp FF Jr

更新日期：2000-01-01 00:00:00

abstract：:A positron-emitter labeled radioligand for the glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor, [(11)C]L-703,717, was examined for its ability to penetrate the brain in animals by simultaneous use with drugs having high-affinity separate binding sites on human serum albumin. [(11)C]L-703,717 has poor ...

journal_title：Nuclear medicine and biology

authors： Haradahira T,Zhang M,Maeda J,Okauchi T,Kawabe K,Kida T,Suzuki K,Suhara1 T

更新日期：2000-05-01 00:00:00

abstract：:The pituitary gonadotropins FSH and LH are secreted into blood as dimeric glycoproteins which display a wide heterogeneity when submitted to technique of separation based on electric charge. That supports the assumption of a major role of the carbohydrates moieties as a source of heterogeneity. No clear difference how...

journal_title：Nuclear medicine and biology

authors： Roger M,Lalhou N

更新日期：1994-04-01 00:00:00

abstract：:The properties of two prospective positron emission tomography (PET) ligands for the delta-opioid receptor, N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) were investigated. Both were antagonists in the mouse vas deferens, and showed high affinity and selectivity, 1.81...

journal_title：Nuclear medicine and biology

authors： Tyacke RJ,Robinson ES,Schnabel R,Lewis JW,Husbands SM,Nutt DJ,Hudson AL

更新日期：2002-05-01 00:00:00

abstract：:L-2,4-Diamino[4-11C]butyric acid (DAB) was synthesized by an enzyme catalysed carrier added (0.1 micromol KCN) reaction of hydrogen [11C]cyanide with O-acetyl-L-serine followed by reduction. L-[11C]DAB was obtained with a radiochemical purity higher than 96% and with a decay corrected radiochemical yield of 30-40% wit...

journal_title：Nuclear medicine and biology

authors： Antoni G,Omura H,Bergström M,Furuya Y,Moulder R,Roberto A,Sundin A,Watanabe Y,Långström B

更新日期：1997-08-01 00:00:00

abstract：:High-affinity iodine- and ethyl-C-5 substituted analogs of 4-hydroxy-3-(3-[11C]methoxyphenyl)-2(1H)-quinolone ([11C]4HQ) were synthesized as new positron emission tomography radioligands for the glycine-binding sites of the N-methyl-d-aspartate (NMDA) ion channel. Although both radioligands showed high in vitro specif...

journal_title：Nuclear medicine and biology

authors： Fuchigami T,Haradahira T,Fujimoto N,Okauchi T,Maeda J,Suzuki K,Suhara T,Yamamoto F,Sasaki S,Mukai T,Yamaguchi H,Ogawa M,Magata Y,Maeda M

更新日期：2008-02-01 00:00:00

abstract：:[¹⁸F]FMISO is the most widely validated PET radiotracer for imaging hypoxic tissue. However, as a result of the pharmacokinetics of [¹⁸F]FMISO a 2h wait between tracer administration and patient scanning is required for optimal image acquisition. In order to develop hypoxia imaging agents with faster kinetics, we have...

journal_title：Nuclear medicine and biology

authors： Laurens E,Yeoh SD,Rigopoulos A,Cao D,Cartwright GA,O'Keefe GJ,Tochon-Danguy HJ,White JM,Scott AM,Ackermann U

更新日期：2014-05-01 00:00:00

abstract：:Fluorine-18 labeled analogs of 8-fluorooctanoic acid and its structurally modified derivatives with methyl or gem-dimethyl branching or with oxygen substitution at the C3 position were prepared using nucleophilic substitution of the tosylate precursors by [18F]fluoride ion, for evaluation as tracers for cerebral fatty...

journal_title：Nuclear medicine and biology

authors： Nagatsugi F,Sasaki S,Maeda M

更新日期：1994-08-01 00:00:00

abstract：:The in vivo brain regional distribution of 2-[18F]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followed the regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in vivo was demonstrated by inhibition with nAC...

journal_title：Nuclear medicine and biology

authors： Horti AG,Scheffel U,Koren AO,Ravert HT,Mathews WB,Musachio JL,Finley PA,London ED,Dannals RF

更新日期：1998-10-01 00:00:00

abstract：INTRODUCTION:Radiolabeled 2-nitroimidazoles (azomycins) are a prominent class of biomarkers for PET imaging of hypoxia. [18F]Fluoro-azomycin-α-arabinoside ([18F]FAZA) - already in clinical use - may be seen as α-configuration nucleoside, but enters cells only via diffusion and is not transported by cellular nucleoside ...

journal_title：Nuclear medicine and biology

authors： Schweifer A,Maier F,Ehrlichmann W,Lamparter D,Kneilling M,Pichler BJ,Hammerschmidt F,Reischl G

更新日期：2016-12-01 00:00:00

abstract：:The application of radionuclide-labeled biomolecules such as monoclonal antibodies or antibody fragments for imaging purposes is called immunoscintigraphy. More specifically, when the nuclides used are positron emitters, such as zirconium-89, the technique is referred to as immuno-PET. Currently, there is an urgent ne...

journal_title：Nuclear medicine and biology

authors： Radchenko V,Bouziotis P,Tsotakos T,Paravatou-Petsotas M,la Fuente Ad,Loudos G,Harris AL,Xanthopoulos S,Filosofov D,Hauser H,Eisenhut M,Ponsard B,Roesch F

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:In previous in-vitro and ex-vivo studies we proved the specific uptake of (99m)Tc radiolabeled chondroitin sulfate (CS) in human articular cartilage. As a logical next step for the clinical use for imaging osteoarthritis we investigated in-vivo uptake of (99m)TcCS in dogs. PROCEDURES:The radiolabeling of CS Co...

journal_title：Nuclear medicine and biology

authors： Sobal G,Velusamy K,Kosik S,Menzel J,Hacker M,Pagitz M

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:3'-Deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) shows great potential as a tracer for proliferative studies with PET. However, its regular application is often limited by low radiochemical yields and the use of a troublesome HPLC separation. Moreover, a high content of ethanol, at least one-fold higher tha...

journal_title：Nuclear medicine and biology

authors： Pascali C,Bogni A,Fugazza L,Cucchi C,Crispu O,Laera L,Iwata R,Maiocchi G,Crippa F,Bombardieri E

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:Positron emission tomography (PET) using O-(2-[(18)F]fluoroethyl)-l-tyrosine (FET) has been successfully employed in the diagnostic workup of brain tumors. Knowledge on the mechanisms of the uptake of radiolabeled amino acids into thyroidal tissues and well-differentiated thyroid carcinomas is limited. We th...

journal_title：Nuclear medicine and biology

authors： Prante O,Bläser D,Maschauer S,Kuwert T

更新日期：2007-04-01 00:00:00

abstract：:The thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) is incorporated into DNA and is resistant to catabolism. We performed pharmacokinetic measurements with [(14)C]FMAU and PET studies with [(11)C]FMAU using rats bearing several different syngeneic tumors. Among normal tissues, FMAU uptake re...

journal_title：Nuclear medicine and biology

authors： Bading JR,Shahinian AH,Vail A,Bathija P,Koszalka GW,Koda RT,Alauddin MM,Fissekis JD,Conti PS

更新日期：2004-05-01 00:00:00

abstract：:Among the ways to deliver comparatively large amounts of boron to cells in vitro for boron neutron capture studies is the linkage of a boronated macromolecule such as polylysine to an antibody. In order to reduce interference with immunoreactivity, boronated polylysine (BPL) was linked to oligosaccharide moieties on t...

journal_title：Nuclear medicine and biology

authors： Novick S,Quastel MR,Marcus S,Chipman D,Shani G,Barth RF,Soloway AH

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:The radiolabeled amino acid O-(2-(18)F-fluoroethyl)-L-tyrosine (FET) and thymidine analogue 3'-deoxy-3'-(18)F-fluorothymidine (FLT) are widely used for positron emission tomography (PET) brain tumor imaging; however, comparative studies are scarce. The aim of this study therefore was to compare FLT and FET P...

journal_title：Nuclear medicine and biology

authors： Nedergaard MK,Michaelsen SR,Perryman L,Erler J,Poulsen HS,Stockhausen MT,Lassen U,Kjaer A

更新日期：2016-03-01 00:00:00

abstract：:The niobium-90 radioisotope ((90)Nb) holds considerable promise for use in immuno-PET, due to its decay parameters (t½ = 14.6h, positron yield=53%, Eß(+)(mean) = 0.35 MeV and Eß(+)(max) = 1.5 MeV). In particular, (90)Nb appears well suited to detect in vivo the pharmacokinetics of large targeting vectors (50-150 kDa)....

journal_title：Nuclear medicine and biology

authors： Radchenko V,Busse S,Roesch F

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:This paper proposes liposomes as a potential new tool for radioimmunotherapy in solid tumours with a two step targeting system. Tumour pretargeting is obtained by using a monoclonal bispecific antibody (BsmAb, anti CEA x anti-DTPA-In) and pegylated liposomes containing lipid-hapten (DSPE-DTPA-In or DSPE-PE...

journal_title：Nuclear medicine and biology

authors： Rauscher A,Frindel M,Maurel C,Maillasson M,Le Saëc P,Rajerison H,Gestin JF,Barbet J,Faivre-Chauvet A,Mougin-Degraef M

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:The present article demonstrates a 'mix-and-use' approach for radiolabeling RGD peptide derivative with (68)Ga, which is easily adaptable in hospital radiopharmacy practice. The radiotracer thus formulated was successfully used for positron emission tomography (PET) imaging of breast cancer in human patien...

journal_title：Nuclear medicine and biology

authors： Chakraborty S,Chakravarty R,Vatsa R,Bhusari P,Sarma HD,Shukla J,Mittal BR,Dash A

更新日期：2016-01-01 00:00:00

abstract：:We evaluated 99mTc-labeled mercaptoacetyltriglycine (99mTc-MAG3)-biocytin as a hepatobiliary imaging agent in the absence and presence of bilirubin in mice. We then compared its pharmacokinetic parameters; peak liver/heart activity ratio (rmax) and half clearance time (HCT) with those of 99mTc-labeled diisopropyl-imin...

journal_title：Nuclear medicine and biology

authors： Kim M,Seidel J,Le N,Kim IS,Yoo TM,Barker C,Kobayashi H,Green MV,Carrasquillo JA,Paik CH

更新日期：1999-01-01 00:00:00

abstract：:Poly(adenosine diphosphate-ribose) synthetase (PARS) is a nuclear enzyme that is activated by deoxyribonucleic acid (DNA) strand breaks and participates in DNA repair. Excessive PARS activation, however, leads to cell death due to depletion of adenosine triphosphate (ATP). To evaluate whether it is possible to detect ...

journal_title：Nuclear medicine and biology

authors： Miyake Y,Kuge Y,Shimadzu H,Hashimoto N,Ishida Y,Shibakawa M,Nishimura T

更新日期：2000-11-01 00:00:00

abstract：:PET centers without particle accelerators make clinical PET widely available at reduced cost. For myocardial perfusion tracers, these satellite PET centers are limited to generator- produced 82Rb(+) and 62Cu[PTSM]. Their limitations motivate a search for transportable alternatives. In search of new tracers we have syn...

journal_title：Nuclear medicine and biology

authors： Studenov AR,Berridge MS

更新日期：2001-08-01 00:00:00

abstract：:Pretargeted tumour imaging was performed in nude mice bearing subcutaneous LS174T human colon cancer xenografts with streptavidin-CC49 monoclonal antibody and 111In-DTPA-biocytin. Mice were administered 250 micrograms of streptavidin-CC49, followed 6 or 9 days later by 40 ng (250 microCi) of 111In-DTPA-biocytin. Tumor...

journal_title：Nuclear medicine and biology

authors： Alvarez-Diez TM,Polihronis J,Reilly RM

更新日期：1996-05-01 00:00:00