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Pretargeted tumour imaging with streptavidin immunoconjugates of monoclonal antibody CC49 and 111In-DTPA-biocytin.

Abstract：

:Pretargeted tumour imaging was performed in nude mice bearing subcutaneous LS174T human colon cancer xenografts with streptavidin-CC49 monoclonal antibody and 111In-DTPA-biocytin. Mice were administered 250 micrograms of streptavidin-CC49, followed 6 or 9 days later by 40 ng (250 microCi) of 111In-DTPA-biocytin. Tumors were visualized at 24 h postinjection of 111In-DTPA-biocytin. Tumour uptake was 0.9-2.5% injected dose/g with tumour/nontarget ratios from 2:1 to 37:1 (except for kidney, which was 0.5-3:1). Tumour uptake in mice pretargeted with streptavidin or streptavidin-conjugated nonspecific normal mouse IgG was < 0.1% i.d./g.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Alvarez-Diez TM,Polihronis J,Reilly RM

doi

10.1016/0969-8051(96)00022-4

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

459-66

issue

4

eissn

0969-8051

issn

1872-9614

pii

0969-8051(96)00022-4

journal_volume

23

pub_type

杂志文章

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