当前位置： SCI文献检索 > NUCLEAR MEDICINE AND BIOLOGY期刊下所有文献 > Inhibition of carnitine-acyl transferase I by oxfenicine studied in vivo with [11C]-labeled fatty acids.

Inhibition of carnitine-acyl transferase I by oxfenicine studied in vivo with [11C]-labeled fatty acids.

Abstract：

METHODS:Anesthetized pigs were studied with [(11)C]-labeled fatty acids (FAs) with carbon chain length ranging from 8 to 16 carbon atoms, during control conditions and during inhibition of carnitine-palmitoyl transferase I (CPT I) with oxfenicine. The myocardial uptake of [(11)C]-FAs from blood was measured together with the relative distribution of [(11)C]-acyl-CoA between rapid mitochondrial oxidation and incorporation into slow turnover lipid pools in the heart. RESULTS:During baseline conditions, the fractional oxidative utilization of palmitate was almost as high as that of carnitine-independent short-chain FAs, unless the carnitine shuttle was inhibited by high levels of lactate. Inhibition of CPT I almost completely blocked the oxidative pathway for palmitic acid and reduced the fractional oxidative utilization, while the rate of oxidative metabolism of acyl-CoA was unaffected. CONCLUSIONS:[(11)C]-Labeled FAs allow rapid oxidation to be well separated from esterification into slow turnover lipid pools in the heart of anaesthetized pigs. The fractional oxidative utilization of [(11)C]-palmitate serves well to characterize, in vivo, the carnitine-dependent transfer of long-chain FAs.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Angsten G,Valind S,Takalo R,Neu H,Meurling S,Långström B

doi

10.1016/j.nucmedbio.2005.03.003

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

495-503

issue

5

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(05)00071-5

journal_volume

32

pub_type

杂志文章

相关文献

NUCLEAR MEDICINE AND BIOLOGY文献大全
  • Fluorine-18-labelled NCQ 115, a selective dopamine D-2 receptor ligand. Preparation and positron emission tomography.

    abstract：:NCQ 115 ((+)-(R)-5-bromo-N-((1-(4-fluorobenzyl)-2-pyrrolidinyl)methyl)-2, 3-dimethoxybenzamide) is a selective dopamine D-2 receptor antagonist. NCQ 115 has a fluorine in a synthetically suitable position in the parent compound and was therefore suggested as a potential 18F-labelled radioligand for positron emission t...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/0969-8051(94)90028-0

    authors： Halldin C,Högberg T,Farde L

    更新日期：1994-05-01 00:00:00

  • 18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation.

    abstract：INTRODUCTION:Several psychiatric and neurodegenerative diseases are associated with malfunction of brain norepinephrine transporter (NET). However, current clinical evaluations of NET function are limited by the lack of sufficiently sensitive methods of detection. To this end, we have synthesized exo-3-[(6-[18F]fluoro-...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2017.10.005

    authors： Kirjavainen AK,Forsback S,López-Picón FR,Marjamäki P,Takkinen J,Haaparanta-Solin M,Peters D,Solin O

    更新日期：2018-01-01 00:00:00

  • Synthesis and evaluation of benzothiophene derivatives as ligands for imaging beta-amyloid plaques in Alzheimer's disease.

    abstract：:The imaging of the distribution of beta-amyloid (Abeta) plaques in the brain is becoming an important diagnostic modality in Alzheimer's disease (AD). Here, we synthesized novel benzothiophene derivatives and labeled them with (18)F for the potential diagnostic imaging of AD patients using positron emission tomography...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2006.06.006

    authors： Chang YS,Jeong JM,Lee YS,Kim HW,Ganesha RB,Kim YJ,Lee DS,Chung JK,Lee MC

    更新日期：2006-08-01 00:00:00

  • 18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury.

    abstract：INTRODUCTION:Molecular imaging of the earliest events related to the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) could facilitate therapeutic development and patient management. We previously reported that 18F-fluoro-2-deoxyglucose (18F-FDG) PET identifies ALI/ARDS prior to radiogr...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2017.01.005

    authors： Rodrigues RS,Bozza FA,Hanrahan CJ,Wang LM,Wu Q,Hoffman JM,Zimmerman GA,Morton KA

    更新日期：2017-05-01 00:00:00

  • Novel one-pot one-step synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ) for benzodiazepine receptor imaging.

    abstract：:We describe the synthesis of 2'-[(18)F]fluoroflumazenil (FFMZ), which differs from the typically used [(18)F]fluoroethylflumazenil (FEFMZ) for benzodiazepine receptor imaging. For one-pot one-step labeling, the precursors, 2'-tosyloxyflumazenil (TFMZ) and 2'-mesyloxyflumazenil (MFMZ), were synthesized in three steps. ...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(03)00030-1

    authors： Yoon YH,Jeong JM,Kim HW,Hong SH,Lee YS,Kil HS,Chi DY,Lee DS,Chung JK,Lee MC

    更新日期：2003-07-01 00:00:00

  • Difference in brain distributions of carbon 11-labeled 4-hydroxy-2(1H)-quinolones as PET radioligands for the glycine-binding site of the NMDA ion channel.

    abstract：:High-affinity iodine- and ethyl-C-5 substituted analogs of 4-hydroxy-3-(3-[11C]methoxyphenyl)-2(1H)-quinolone ([11C]4HQ) were synthesized as new positron emission tomography radioligands for the glycine-binding sites of the N-methyl-d-aspartate (NMDA) ion channel. Although both radioligands showed high in vitro specif...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2007.10.007

    authors： Fuchigami T,Haradahira T,Fujimoto N,Okauchi T,Maeda J,Suzuki K,Suhara T,Yamamoto F,Sasaki S,Mukai T,Yamaguchi H,Ogawa M,Magata Y,Maeda M

    更新日期：2008-02-01 00:00:00

  • Investigation of a potential scintigraphic marker of apoptosis: radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone.

    abstract：:The imaging of apoptosis represents an attractive diagnostic goal in the area of tumor therapy, degenerative diseases and organ transplantation. Since caspases play a key role during the early period of the intracellular signal cascade of cells undergoing apoptosis we considered benzyloxycarbonyl-Val-Ala-DL-Asp(O-meth...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(01)00247-5

    authors： Haberkorn U,Kinscherf R,Krammer PH,Mier W,Eisenhut M

    更新日期：2001-10-01 00:00:00

  • Radioiodinated N-(alkylaminoalkyl)-substituted 4-methoxy-, 4-hydroxy-, and 4-aminobenzamides: biological investigations for the improvement of melanoma-imaging agents.

    abstract：:The syntheses and radiolabelling of 27 new N-(alkylaminoalkyl)-4-methoxy-, -4-hydroxy-, and -4-aminobenzamides are described and evaluated in C57B1/6 mice with subcutaneously transplanted B16 melanoma in order to screen the optimal chemical structure for melanoma scintigraphy. Using T1(TFA)3 for 131I- labelling, a ser...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(97)00024-3

    authors： Mohammed A,Nicholl C,Titsch U,Eisenhut M

    更新日期：1997-07-01 00:00:00

  • Imaging of striatal dopamine transporters in rat brain with single pinhole SPECT and co-aligned MRI is highly reproducible.

    abstract：:A recently developed pinhole high-resolution SPECT system was used to measure striatal to non-specific binding ratios in rats (n = 9), after injection of the dopamine transporter ligand (123)I-FP-CIT, and to assess its test/retest reproducibility. For co-alignment purposes, the rat brain was imaged on a 1.5 Tesla clin...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(03)00046-5

    authors： Booij J,de Bruin K,de Win MM,Lavini C,den Heeten GJ,Habraken JB

    更新日期：2003-08-01 00:00:00

  • Determination of the target volume of HeLa cells treated with platinum-195m radiolabeled trans-diaminedichloroplatinum(II): a comparison with cis-diaminedichloroplatinum(II).

    abstract：:HeLa S-3 cells were treated with 195mPt-radiolabeled trans-diaminedichloroplatinum(II) (TDDP) under various conditions, and the relationship between lethal effect and the number of Pt atoms binding to DNA, RNA and proteins was examined. The mean lethal concentrations for the cells treated with TDDP at 37 degrees C for...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/0969-8051(93)90068-6

    authors： Akaboshi M,Kawai K,Maki H,Akuta K,Ujeno Y,Ono K,Miyahara T

    更新日期：1993-05-01 00:00:00

  • The synthesis, magnetic purification and evaluation of 99mTc-labeled microbubbles.

    abstract：INTRODUCTION:Ultrasound (US) contrast agents based on microbubbles (MBs) are being investigated as platforms for drug and gene delivery. A methodology for determining the distribution and fate of modified MBs quantitatively in vivo can be achieved by tagging MBs directly with (99m)Tc. This creates the opportunity to em...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2011.04.008

    authors： Lazarova N,Causey PW,Lemon JA,Czorny SK,Forbes JR,Zlitni A,Genady A,Foster FS,Valliant JF

    更新日期：2011-11-01 00:00:00

  • Liver distribution of 99mTc-DL-homocysteine in experimental hepatitis rats.

    abstract：:Liver accumulation of 99mTc-DL-homocysteine (99mTc-Hcy), which had been found to accumulate in several experimental tumors, was studied using experimental hepatitis models of rats. The distribution of this compound in liver of rats treated with CCl4 (25-100 microL/100 g body weight) was more than five times higher tha...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/0969-8051(93)90091-8

    authors： Takeda A,Okumura H,Okada S

    更新日期：1993-11-01 00:00:00

  • A strategy for increasing the brain uptake of a radioligand in animals: use of a drug that inhibits plasma protein binding.

    abstract：:A positron-emitter labeled radioligand for the glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor, [(11)C]L-703,717, was examined for its ability to penetrate the brain in animals by simultaneous use with drugs having high-affinity separate binding sites on human serum albumin. [(11)C]L-703,717 has poor ...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(00)00096-2

    authors： Haradahira T,Zhang M,Maeda J,Okauchi T,Kawabe K,Kida T,Suzuki K,Suhara1 T

    更新日期：2000-05-01 00:00:00

  • Comparison of non-isotopic exchange methods for n.c.a. labelling of 2-iodophenyl-metyrapone.

    abstract：:The Cu(I)-assisted aromatic halogen exchange proved useful for preparation of macroscopic amounts of 2-iodophenyl-metyrapone as well as for the n.c.a. radioiodinated analogue. Semi-preparative HPLC-isolation provided the compound with high purity for use as chromatographic standard and for the determination of the inh...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/0969-8051(95)02033-0

    authors： Schirbel A,Coenen HH

    更新日期：1995-11-01 00:00:00

  • Novel chelating agents for potential clinical applications of copper.

    abstract：:Copper offers a unique selection of radioisotopes ((60)Cu, (61)Cu, (62)Cu, (64)Cu, and (67)Cu) with half-lives ranging from 9.8 min to 61.9 h suitable for imaging and/or radiotherapy. In peptide/antibody targeted radiotherapy one of the most studied chelating agents for copper, 1,4,8,11-tetraazacyclotetradecane-1,4,8,...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1016/s0969-8051(01)00287-6

    authors： Ma D,Lu F,Overstreet T,Milenic DE,Brechbiel MW

    更新日期：2002-01-01 00:00:00

  • Radiolabelling and evaluation of a novel sulfoxide as a PET imaging agent for tumor hypoxia.

    abstract：:[¹⁸F]FMISO is the most widely validated PET radiotracer for imaging hypoxic tissue. However, as a result of the pharmacokinetics of [¹⁸F]FMISO a 2h wait between tracer administration and patient scanning is required for optimal image acquisition. In order to develop hypoxia imaging agents with faster kinetics, we have...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2014.03.001

    authors： Laurens E,Yeoh SD,Rigopoulos A,Cao D,Cartwright GA,O'Keefe GJ,Tochon-Danguy HJ,White JM,Scott AM,Ackermann U

    更新日期：2014-05-01 00:00:00

  • N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) potential delta-opioid receptor PET ligands.

    abstract：:The properties of two prospective positron emission tomography (PET) ligands for the delta-opioid receptor, N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) were investigated. Both were antagonists in the mouse vas deferens, and showed high affinity and selectivity, 1.81...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(02)00300-1

    authors： Tyacke RJ,Robinson ES,Schnabel R,Lewis JW,Husbands SM,Nutt DJ,Hudson AL

    更新日期：2002-05-01 00:00:00

  • Synthesis and in vivo evaluation of [O-methyl-11C](2R,4R)-4-hydroxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine as a 5-HT2A receptor PET ligand.

    abstract：:The serotonin2A (5-HT2A) receptor is implicated in the pathophysiology of schizophrenia and mood disorders, and in vivo studies of this receptor would be of value in studying the pathophysiology of these disorders and in measuring the relationship of clinical response to receptor occupancy for 5-HT2A antagonists such ...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2006.02.001

    authors： Kumar JS,Prabhakaran J,Erlandsson K,Majo VJ,Simpson NR,Pratap M,Van Heertum RL,Mann JJ,Parsey RV

    更新日期：2006-05-01 00:00:00

  • Studies on 177Lu-labeled methylene diphosphonate as potential bone-seeking radiopharmaceutical for bone pain palliation.

    abstract：OBJECTIVE:(99m)Tc-MDP (technetium-99(m)-labeled methylene diphosphonate) has been widely used as a radiopharmaceutical for bone scintigraphy in cases of metastatic bone disease. (177)Lu is presently considered as an excellent radionuclide for developing bone pain palliation agents. No study on preparing a complex of (1...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2010.09.013

    authors： Abbasi IA

    更新日期：2011-04-01 00:00:00

  • Fluorine-18 labeled diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain.

    abstract：OBJECTIVES:Serotonin transporters (SERT) play an important role in controlling serotonin concentration in the synaptic cleft and in managing postsynaptic signal transduction. Inhibitors of SERT binding are well known as selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, sertraline, paroxetine, and esci...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2018.06.008

    authors： Zhang Y,Liu F,Xiao H,Yao X,Li G,Choi SR,Ploessl K,Zha Z,Zhu L,Kung HF

    更新日期：2018-11-01 00:00:00

  • Optimization, biological evaluation and microPET imaging of copper-64-labeled bombesin agonists, [64Cu-NO2A-(X)-BBN(7-14)NH2], in a prostate tumor xenografted mouse model.

    abstract：UNLABELLED:Gastrin-releasing peptide receptors (GRPr) are a member of the bombesin (BBN) receptor family. GRPr are expressed in high numbers on specific human cancers, including human prostate cancer. Therefore, copper-64 ((64)Cu) radiolabeled BBN(7-14)NH(2) conjugates could have potential for diagnosis of human prosta...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2010.04.016

    authors： Lane SR,Nanda P,Rold TL,Sieckman GL,Figueroa SD,Hoffman TJ,Jurisson SS,Smith CJ

    更新日期：2010-10-01 00:00:00

  • [(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy.

    abstract：:Cocaine was initially labeled with carbon-11 in order to track the distribution and pharmacokinetics of this powerful stimulant and drug of abuse in the human brain and body. It was soon discovered that [(11)C]cocaine was not only useful for measuring cocaine pharmacokinetics and its relationship to behavior but that ...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章,评审

    doi：10.1016/s0969-8051(01)00211-6

    authors： Fowler JS,Volkow ND,Wang GJ,Gatley SJ,Logan J

    更新日期：2001-07-01 00:00:00

  • Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model.

    abstract：UNLABELLED:The purpose of this study is to reveal characteristics of (64)Cu-labeled diacetyl-bis(N(4)-methylthiosemicarbazone) ([(64)Cu]Cu-ATSM) during cell proliferation and hypoxia by autoradiography imaging and immunohistochemical staining. METHODS:The intratumoral distributions of [(64)Cu]Cu-ATSM and [(18)F]-2-flu...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2009.01.016

    authors： Oh M,Tanaka T,Kobayashi M,Furukawa T,Mori T,Kudo T,Fujieda S,Fujibayashi Y

    更新日期：2009-05-01 00:00:00

  • A new 99mTc-complex with a germanium-hydrazide (GeTH) ligand.

    abstract：:A new tetrahydrazido-germanium (GeTH) ligand was synthesized, characterized and complexed with 99mTc. The negatively charged 99mTc-chelate was shown to form in high yields at neutral pH in the absence of other reducing agents and exhibits high in vitro and in vivo stability. ...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/0969-8051(94)90184-8

    authors： Singh PR,Katti KK,Katti KV,Corlija M,Ketring AR,Volkert WA,Holmes RR

    更新日期：1994-11-01 00:00:00

  • Luminescence imaging using radionuclides: a potential application in molecular imaging.

    abstract：INTRODUCTION:Nuclear and optical imaging are complementary in many aspects and there would be many advantages when optical imaging probes are prepared using radionuclides rather than classic fluorophores, and when nuclear and optical dual images are obtained using single imaging probe. METHODS:The luminescence intensi...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2010.09.003

    authors： Park JC,Il An G,Park SI,Oh J,Kim HJ,Su Ha Y,Wang EK,Min Kim K,Kim JY,Lee J,Welch MJ,Yoo J

    更新日期：2011-04-01 00:00:00

  • Ultrafast LC method for purification and metabolite analysis of PET probes.

    abstract：:An ultrafast and efficient high-performance liquid chromatographic (LC) method was developed to purify positron emission tomography (PET) radiopharmaceuticals as well as for metabolite analysis of the plasma sample. Chromatographic separation was achieved on a short (60 mm length) semipreparative (10 mm I.D.) column p...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2009.08.002

    authors： Nakao R,Ito T,Hayashi K,Fukumura T,Suzuki K

    更新日期：2010-01-01 00:00:00

  • Radiosynthesis of [11C]brofaromine, a potential tracer for imaging monoamine oxidase A.

    abstract：:Brofaromine (4-5(-methoxy-7-bromobenzofuranyl)-2-piperidine-HCl) is a potent and selective inhibitor of monoamine oxidase (MAO) A. Two methods for its synthesis and a preliminary positron emission tomography (PET) evaluation in monkey brain are described. The first method, at low carrier concentration of CO2, consiste...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/0969-8051(95)02051-9

    authors： Ametamey SM,Beer HF,Guenther I,Antonini A,Leenders KL,Waldmeier PC,Schubiger PA

    更新日期：1996-04-01 00:00:00

  • Synthesis of [11C]interleukin 8 using a cell-free translation system and L-[11C]methionine.

    abstract：:Positron emission tomography (PET), which requires a compound labeled with a positron emitter radioisotope as an imaging probe, is one of the most useful and valuable imaging modalities in molecular imaging. It has several advantages over other imaging modalities, particularly in sensitive and quantitative investigati...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2011.07.005

    authors： Harada R,Furumoto S,Yoshikawa T,Ishikawa Y,Shibuya K,Okamura N,Iwata R,Yanai K

    更新日期：2012-01-01 00:00:00

  • Fluorine-18-labeled fluorine gas for synthesis of tracer molecules.

    abstract：:The aim of this work was to develop a method to produce 18F-labeled fluorine gas ([18F]F2) with high specific radioactivity (SA, radioactivity/mass-ratio). 18F-Labeled methyl fluoride ([18F]CH3F) was synthesized from [18F]F-aq and mixed with carrier F2 in an inert neon matrix. The constituents were atomized in an elec...

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/s0969-8051(97)00078-4

    authors： Bergman J,Solin O

    更新日期：1997-10-01 00:00:00

  • Noninvasive visualization and quantification of tumor αVβ3 integrin expression using a novel positron emission tomography probe, 64Cu-cyclam-RAFT-c(-RGDfK-)4.

    abstract：INTRODUCTION:The α(V)β(3) integrin is a well-known transmembrane receptor involved in tumor invasion, angiogenesis and metastasis. Our aim was to evaluate a novel positron emission tomography (PET) probe, (64)Cu-cyclam-RAFT-c(-RGDfK-)(4), for noninvasive visualization and quantification of α(V)β(3) integrin expression....

    journal_title：Nuclear medicine and biology

    pub_type： 杂志文章

    doi：10.1016/j.nucmedbio.2010.11.008

    authors： Jin ZH,Furukawa T,Galibert M,Boturyn D,Coll JL,Fukumura T,Saga T,Dumy P,Fujibayashi Y

    更新日期：2011-05-01 00:00:00