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Imaging of striatal dopamine transporters in rat brain with single pinhole SPECT and co-aligned MRI is highly reproducible.

Abstract：

:A recently developed pinhole high-resolution SPECT system was used to measure striatal to non-specific binding ratios in rats (n = 9), after injection of the dopamine transporter ligand (123)I-FP-CIT, and to assess its test/retest reproducibility. For co-alignment purposes, the rat brain was imaged on a 1.5 Tesla clinical MRI scanner using a specially developed surface coil. The SPECT images showed clear striatal uptake. On the MR images, cerebral and extra-cerebral structures could be easily delineated. The mean striatal to non-specific [(123)I]FP-CIT binding ratios of the test/retest studies were 1.7 +/- 0.2 and 1.6 +/- 0.2, respectively. The test/retest variability was approximately 9%. We conclude that the assessment of striatal [(123)I]FP-CIT binding ratios in rats is highly reproducible.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Booij J,de Bruin K,de Win MM,Lavini C,den Heeten GJ,Habraken JB

doi

10.1016/s0969-8051(03)00046-5

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

643-9

issue

6

eissn

0969-8051

issn

1872-9614

pii

S0969805103000465

journal_volume

30

pub_type

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