Column-switching HPLC for the analysis of plasma in PET imaging studies.

Abstract:

:A column-switch high performance liquid chromatography method for the analysis of 4 mL of plasma is described with six examples of chromatography of [(11)C]-labeled positron-emission tomography imaging agents. Complete extraction of all but the most polar metabolites by the reverse phase capture column is achieved by disruption of plasma protein binding by 8 M urea.

journal_name

Nucl Med Biol

authors

Hilton J,Yokoi F,Dannals RF,Ravert HT,Szabo Z,Wong DF

doi

10.1016/s0969-8051(00)00125-6

keywords:

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

627-30

issue

6

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(00)00125-6

journal_volume

27

pub_type

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