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Physical optimization of production by deuteron irradiation of high specific activity (177g)Lu suitable for radioimmunotherapy.

Abstract：

:Deuteron-induced nuclear reactions for generation of no-carrier-added (NCA) Lu isotopes were investigated using the stacked-foil activation technique on natural Yb targets at energies up to Ed=18.18MeV. The decay curve of ¹⁷⁷Yb, the growth curve of the cumulative (direct and indirect) and the direct production of (177g)Lu were determined. The analysis of these curves conducts to the evidence that the predominant route for the production of (177g)Lu is the indirect reaction ¹⁷⁶Yb(d,p)¹⁷⁷Yb, which decays to (177g)Lu. In the spectra acquired one year from the EOB the γ lines of (177m)Lu are not evident. A comparison between the calculated activity of (177g)Lu produced with a cyclotron and with a nuclear reactor is given.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Manenti S,Bonardi ML,Gini L,Groppi F

doi

10.1016/j.nucmedbio.2014.02.007

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

407-9

issue

5

eissn

0969-8051

issn

1872-9614

pii

S0969-8051(14)00048-1

journal_volume

41

pub_type

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