Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method.

abstract：:The goal of this study was to investigate the potential use of a radioiodinated benzamide, N-[2-(1'-piperidinyl)ethyl]-3-iodo[125I]-4-methoxybenzamide (P[125I]MBA), a sigma receptor binding radioligand for imaging breast cancer. The chemical and radiochemical syntheses of PIMBA are described. The pharmacological evalu...

journal_title：Nuclear medicine and biology

authors： John CS,Bowen WD,Fisher SJ,Lim BB,Geyer BC,Vilner BJ,Wahl RL

更新日期：1999-05-01 00:00:00

abstract：:The properties of two prospective positron emission tomography (PET) ligands for the delta-opioid receptor, N1'-fluoroethyl-naltrindole (BU97001) and N1'-fluoroethyl-(14-formylamino)-naltrindole (BU97018) were investigated. Both were antagonists in the mouse vas deferens, and showed high affinity and selectivity, 1.81...

journal_title：Nuclear medicine and biology

authors： Tyacke RJ,Robinson ES,Schnabel R,Lewis JW,Husbands SM,Nutt DJ,Hudson AL

更新日期：2002-05-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) such as the tumor-specific anti-epidermal growth factor receptor variant III (EGFRvIII) that are internalized and degraded after cell binding necessitate the use of radioiodination methods that minimize the loss of radioactivity from the tumor cell after intracellular processing. The purpo...

journal_title：Nuclear medicine and biology

authors： Vaidyanathan G,Affleck DJ,Bigner DD,Zalutsky MR

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Noninvasive imaging of small animals to measure biodistributions and pharmacokinetics of radiolabeled agents is increasingly seen as an effective alternative to external counting of tissues obtained by sacrifice and dissection. However, we have observed important disagreements in measuring the accumulation...

journal_title：Nuclear medicine and biology

authors： Cheng D,Rusckowski M,Pretorius PH,Chen L,Xiao N,Liu Y,Liu G,Liang M,Liu X,Dou S,Hnatowich DJ

更新日期：2011-08-01 00:00:00

abstract：:3-Amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile, labeled with carbon-11 ([11C]-DASB), is a recently introduced radiotracer for imaging the serotonin transporter (SERT) by positron emission tomography (PET). A series of in vitro and in vivo experiments were performed to further characterise the properties...

journal_title：Nuclear medicine and biology

authors： Wilson AA,Ginovart N,Hussey D,Meyer J,Houle S

更新日期：2002-07-01 00:00:00

abstract：INTRODUCTION:Telmisartan, a nonpeptide angiotensin II AT1 receptor antagonist used as an antihypertensive drug, is specifically taken up by the liver through the OATP1B3. PET imaging with [(11)C]telmisartan is expected to provide information about the whole body pharmacokinetics of telmisartan as well as its transport ...

journal_title：Nuclear medicine and biology

authors： Shimizu K,Takashima T,Yamane T,Sasaki M,Kageyama H,Hashizume Y,Maeda K,Sugiyama Y,Watanabe Y,Senda M

更新日期：2012-08-01 00:00:00

abstract：:The aim of the study was to evaluate the diagnostic accuracy of scintimammography with Tc-99m MIBI for the detection of breast cancer. Patients with a suspicious lesion detected by palpation or mammography were included in the study. Excisional biopsy was performed on all patients. Mammography was performed within 3 w...

journal_title：Nuclear medicine and biology

authors： Palmedo H,Schomburg A,Grünwald F,Mallmann P,Boldt I,Biersack HJ

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:To evaluate the effectiveness of PET in differentiating malignant from benign pancreatic cystic tumors. METHODS:Between 2009 and 2010, all patients with pancreatic cystic tumors who had PET, triple phase contrast computed tomography (CT) and endoscopic ultrasound (EUS) were reviewed. Clinicopathological cha...

journal_title：Nuclear medicine and biology

authors： Zhang Y,Frampton AE,Martin JL,Kyriakides C,Bong JJ,Habib NA,Vlavianos P,Jiao LR

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:The neurohistological findings in patients treated with targeted beta emitters such as (131)I are poorly described. We report a histopathologic analysis from patients treated with combined external beam therapy and a brachytherapy consisting of a (131)I-labeled monoclonal antibody (mAb) injected into surgi...

journal_title：Nuclear medicine and biology

authors： McLendon RE,Akabani G,Friedman HS,Reardon DA,Cleveland L,Cokgor I,Herndon JE 2nd,Wikstrand C,Boulton ST,Friedman AH,Bigner DD,Zalutsky MR

更新日期：2007-05-01 00:00:00

abstract：:An in vivo estimation of the newly synthesized MAO-A specific inhibitor, [125I]-labeled N-[3(2,4-dichloro-6-iodophenoxy)propyl]-N-methyl-2- propynylamine ([125I]-iodoclorgyline), was performed. Retention of the radioactivity of this radioligand was observed in the brain from 1 h post-injection. Pretreatments with clor...

journal_title：Nuclear medicine and biology

authors： Hirata M,Magata Y,Ohmomo Y,Saji H,Murakami K,Takagaki T,Yamamura N,Tanaka C,Konishi J,Yokoyama A

更新日期：1995-02-01 00:00:00

abstract：:The pyridopyrimidinones are a potent class of inhibitors of c-Abl kinase and Bcr-Abl kinase, the causative fusion protein in chronic myelogenous leukemia and Src family kinases. A novel method for routine, high-yield no-carrier-added synthesis of [(124)I]-, [(125)I]- and [(131)I]-6-(2,6-dichlorophenyl)-2-(4-iodophenyl...

journal_title：Nuclear medicine and biology

authors： Veach DR,Namavari M,Beresten T,Balatoni J,Minchenko M,Djaballah H,Finn RD,Clarkson B,Gelovani JG,Bornmann WG,Larson SM

更新日期：2005-05-01 00:00:00

abstract：:A new positron emission tomography (PET) radioligand for the serotonin transporter (SERT), [(11)C]2-[2-[[(dimethylamino)methyl]phenyl]thio]-5-(2-fluoroethyl)phenylamine ([(11)C]AFE, 12), was synthesized and evaluated in vivo in rats and baboons. [(11)C]AFE (12) was prepared from its monomethylamino precursor 11 by rea...

journal_title：Nuclear medicine and biology

authors： Zhu Z,Guo N,Narendran R,Erritzoe D,Ekelund J,Hwang DR,Bae SA,Laruelle M,Huang Y

更新日期：2004-11-01 00:00:00

abstract：:Most radioligands are substantially metabolised in peripheral organs during the course of positron emission tomography (PET) recordings. Accurate determination of plasma concentrations of unmetabolised radioligands is often important for quantification of data from PET studies. The fractions of untransformed radioliga...

journal_title：Nuclear medicine and biology

authors： Gillings NM,Bender D,Falborg L,Marthi K,Munk OL,Cumming P

更新日期：2001-01-01 00:00:00

abstract：METHODS:Anesthetized pigs were studied with [(11)C]-labeled fatty acids (FAs) with carbon chain length ranging from 8 to 16 carbon atoms, during control conditions and during inhibition of carnitine-palmitoyl transferase I (CPT I) with oxfenicine. The myocardial uptake of [(11)C]-FAs from blood was measured together wi...

journal_title：Nuclear medicine and biology

authors： Angsten G,Valind S,Takalo R,Neu H,Meurling S,Långström B

更新日期：2005-07-01 00:00:00

abstract：:The pituitary gonadotropins FSH and LH are secreted into blood as dimeric glycoproteins which display a wide heterogeneity when submitted to technique of separation based on electric charge. That supports the assumption of a major role of the carbohydrates moieties as a source of heterogeneity. No clear difference how...

journal_title：Nuclear medicine and biology

authors： Roger M,Lalhou N

更新日期：1994-04-01 00:00:00

abstract：:Multiple myeloma and other hematological malignancies have been treated by myeloablative radiotherapy/chemotherapy and subsequent stem cell transplantation. [(166)Dy]Dy/(166)Ho-ethylenediaminetetramethylene phosphonate (EDTMP) forms a stable in vivo generator system with selective skeletal uptake in mice; therefore, i...

journal_title：Nuclear medicine and biology

authors： Pedraza-López M,Ferro-Flores G,Arteaga de Murphy C,Morales-Ramírez P,Piedras-Ross J,Murphy-Stack E,Hernández-Oviedo O

更新日期：2004-11-01 00:00:00

abstract：INTRODUCTION:As the use of metallic radionuclides increases, so does the demand for a simple production method. In this study, we demonstrated an in situ target processing concept for automated metallic radionuclide production without the use of any robotic device. METHODS:An alumina ceramic vessel for a vertical irra...

journal_title：Nuclear medicine and biology

authors： Nagatsu K,Suzuki H,Fukada M,Minegishi K,Tsuji A,Fukumura T

更新日期：2012-11-01 00:00:00

abstract：:Cocaine was initially labeled with carbon-11 in order to track the distribution and pharmacokinetics of this powerful stimulant and drug of abuse in the human brain and body. It was soon discovered that [(11)C]cocaine was not only useful for measuring cocaine pharmacokinetics and its relationship to behavior but that ...

journal_title：Nuclear medicine and biology

authors： Fowler JS,Volkow ND,Wang GJ,Gatley SJ,Logan J

更新日期：2001-07-01 00:00:00

abstract：UNLABELLED:(18)F-9-fluoropropyl-(+)-dihydrotetrabenazine ((18)F-AV-133) is a novel positron emission tomography tracer for imaging the vesicular monoamine transporter II in dopaminergic neuron degeneration, which might be indicative for Parkinson's disease (PD) and other parkinsonism. Studies were performed to optimize...

journal_title：Nuclear medicine and biology

authors： Lin KJ,Lin WY,Hsieh CJ,Weng YH,Wey SP,Lu CS,Skovronsky D,Yen TC,Chang CJ,Kung MP,Hsiao IT

更新日期：2011-11-01 00:00:00

abstract：:The herpes simplex virus type 1 thymidine kinase (HSV1-TK) reporter system is being used to directly and indirectly monitor therapeutic gene expression, immune cell trafficking and protein-protein interactions in various living animals. However, the issues of HSV1-TK enzyme stability in living cells and whether this r...

journal_title：Nuclear medicine and biology

authors： Hsieh CH,Liu RS,Wang HE,Hwang JJ,Deng WP,Chen JC,Chen FD

更新日期：2006-07-01 00:00:00

abstract：:Fluorine-18 labeled 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nort ropane (FECNT) was synthesized in the development of a dopamine transporter (DAT) imaging ligand for positron emission tomography (PET). The methods of radiolabeling and ligand synthesis of FECNT, and the results of the in vitro charac...

journal_title：Nuclear medicine and biology

authors： Goodman MM,Kilts CD,Keil R,Shi B,Martarello L,Xing D,Votaw J,Ely TD,Lambert P,Owens MJ,Camp VM,Malveaux E,Hoffman JM

更新日期：2000-01-01 00:00:00

abstract：:We investigated sigma(1) and dopamine D(2) receptor occupancy in mouse brain after a single injection of haloperidol, nemonapride, or spiperone using [(11)C]SA4503 and [(11)C]raclopride, respectively. Co-injection of the three compounds significantly blocked the uptake of each radioligand. Six hours later, only halope...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Kawamura K,Kobayashi T,Matsuno K

更新日期：2003-05-01 00:00:00

abstract：:We examined transport of 3-[(125)I]iodo-alpha-methyl-L-tyrosine ([(125)I]IMT) in Xenopus laevis oocytes co-expressing human L-type amino acid transporter 1 (a component of system L) and human 4F2hc. Human LAT1 mediated transport of [(125)I]IMT. [(125)I]IMT uptake was decreased by the presence of L-isomers of Cys, Leu,...

journal_title：Nuclear medicine and biology

authors： Shikano N,Kanai Y,Kawai K,Ishikawa N,Endou H

更新日期：2003-01-01 00:00:00

abstract：:[11C]Methamphetamine, a psychotropic agent, was synthesized by N-methylation of amphetamine with [11C]CH3 I in hopes that it could be applied in the near future to assist positron emission tomography (PET) in the imaging of its distribution in the human brain. The regional distribution of [11C]methamphetamine was inve...

journal_title：Nuclear medicine and biology

authors： Mizugaki M,Hishinuma T,Nakamura H,Yamashita M,Shimomura K,Itoh K,Hirose A,Tomioka Y,Aso H,Edo K

更新日期：1993-05-01 00:00:00

abstract：:Rhenium-186 (Re-186) hydroxyethylidene diphosphonate (HEDP) has been shown to localize in metastatic foci within bone in a manner similar to Tc-99m bone-seeking agents. Usually, in the preparation of diagnostic Tc-99m radiopharmaceuticals, the concentration of Tc is at trace level (10(-8) M). However, large amounts of...

journal_title：Nuclear medicine and biology

authors： Lin WY,Hsieh JF,Lin CP,Hsieh BT,Ting G,Wang SJ,Knapp FF Jr

更新日期：1999-05-01 00:00:00

abstract：:A simple method is described for affinity purification of radiolabeled antibodies using glutaraldehyde-fixed tumor target cells. The cell-bound antibody fraction is removed from the cells by an acid wash and then immediately subjected to buffer-exchange chromatography. The method was applied to the D3 murine monoclona...

journal_title：Nuclear medicine and biology

authors： Juweid M,Sato J,Paik C,Onay-Basaran S,Weinstein JN,Neumann RD

更新日期：1993-04-01 00:00:00

abstract：:Melanin, a natural biological pigment present in many organisms, has been found to exhibit multiple functions. An important property of melanin is its ability to chelate metal ions strongly, which might be developed as an iron chelator for iron overload therapy. Herein, we prepared the ultrasmall water-soluble melanin...

journal_title：Nuclear medicine and biology

authors： Zhang P,Yue Y,Pan D,Yang R,Xu Y,Wang L,Yan J,Li X,Yang M

更新日期：2016-09-01 00:00:00

abstract：:The discovery of neuroendocrine differentiation in hormone-refractory prostatic adenocarcinoma has opened a potentially new therapeutic approach in this group of patients with a poor prognosis and few effective therapy modalities. Based on previous findings of increased uptake of 11C-5-hydroxytryptophan (11C-5-HTP) in...

journal_title：Nuclear medicine and biology

authors： Kälkner KM,Ginman C,Nilsson S,Bergström M,Antoni G,Ahlström H,Långström B,Westlin JE

更新日期：1997-05-01 00:00:00

abstract：:The synthetic porphyrins, N-benzyl-5,10,15,20-tetrakis (4-carboxyphenyl) porphine (N-bzHTCPP) and N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl) porphine (N-bzHCS3P), represent excellent radiocopper chelating agents that may find utility in antibody-mediated diagnosis and/or therapy. N-bzHCS3P was co...

journal_title：Nuclear medicine and biology

authors： Bhalgat MK,Roberts JC,Mercer-Smith JA,Knotts BD,Vessella RL,Lavallee DK

更新日期：1997-02-01 00:00:00

abstract：INTRODUCTION:(99m)Tc-BnAO is one of the nonnitroimidazole hypoxia markers with the highest citation and could be potentially useful in both oncology and other clinical applications. However, it appears inferior in vitro due to lower absolute accumulation and smaller anoxic/normoxic uptake ratio. It is possible that the...

journal_title：Nuclear medicine and biology

authors： Sun X,Chu T,Wang X

更新日期：2010-02-01 00:00:00