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Metabolism of receptor targeted 111In-DTPA-glycoproteins: identification of 111In-DTPA-epsilon-lysine as the primary metabolic and excretory product.

Abstract：

:The hepatic and renal retention of indium-111 (111In) from 111In-labeled polypeptides has been the subject of many investigations. Because the lysosome is a common intracellular destination for the degradation of polypeptides, we studied the lysosomal metabolism of 111In-DTPA-labeled glycoproteins targeted to cell surface receptors in vitro and in vivo. We found that 111In-DTPA-glycoproteins were degraded to 111In-DTPA-epsilon-lysine, which was slowly released from cells and recovered intact in urine and feces. These results suggest a mechanism for 111In retention at target and non-target sites.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Franano FN,Edwards WB,Welch MJ,Duncan JR

doi

10.1016/0969-8051(94)90174-0

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

1023-34

issue

8

eissn

0969-8051

issn

1872-9614

journal_volume

21

pub_type

杂志文章

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