Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system.

Abstract:

:Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.

journal_name

Nucl Med Biol

authors

Liu Z,Stevenson GD,Barrett HH,Kastis GA,Bettan M,Furenlid LR,Wilson DW,Woolfenden JM

doi

10.1016/s0969-8051(03)00119-7

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

53-65

issue

1

eissn

0969-8051

issn

1872-9614

pii

S0969805103001197

journal_volume

31

pub_type

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