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First-pass studies of acute lung injury.

Abstract：

:Mild hydrochloric acid was introduced to a caudal lung section in each of eight dogs to induce injury. Transits of 99mTc-labeled red blood cells (RBC) and [123I]iodoantipyrine (IAP) injected intravenously were recorded by a scintillation camera. Lungs and blood samples were analyzed post-mortem. Peak-to-equilibrium ratios (P/E) of RBC time-activity curves were computed to be 3.83 +/- 0.54 for the control lung, 2.58 +/- 0.55 for the injured lung and 2.23 +/- 0.58 for the injured caudal section. For IAP, the respective results were 3.78 +/- 0.29, 2.02 +/- 0.18 and 1.77 +/- 0.17. The decrease of P/E in injured areas was attributed to reduced blood flow. Using mean transit times of the tracers, we computed extravascular lung water per unit blood volume to be 0.35 +/- 0.18 for the control lungs and an increased value of 0.68 +/- 0.24 for the injured lungs. These results displayed sensitivity to injury, but were gross underestimates relative to the corresponding values of 2.04 +/- 0.54 and 4.56 +/- 1.85 in post-mortem analyses.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

Chu RY,Sidhu N,Basmadjian G,Burow R,Allen EW

doi

10.1016/0969-8051(93)90154-m

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

875-9

issue

7

eissn

0969-8051

issn

1872-9614

pii

0969-8051(93)90154-M

journal_volume

20

pub_type

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