[125/123I] 5-Iodo-3-pyridyl ethers. syntheses and binding to neuronal nicotinic acetylcholine receptors.

abstract：:The herpes simplex virus type 1 thymidine kinase (HSV1-TK) reporter system is being used to directly and indirectly monitor therapeutic gene expression, immune cell trafficking and protein-protein interactions in various living animals. However, the issues of HSV1-TK enzyme stability in living cells and whether this r...

journal_title：Nuclear medicine and biology

authors： Hsieh CH,Liu RS,Wang HE,Hwang JJ,Deng WP,Chen JC,Chen FD

更新日期：2006-07-01 00:00:00

abstract：INTRODUCTION:(99m)Tc-BnAO is one of the nonnitroimidazole hypoxia markers with the highest citation and could be potentially useful in both oncology and other clinical applications. However, it appears inferior in vitro due to lower absolute accumulation and smaller anoxic/normoxic uptake ratio. It is possible that the...

journal_title：Nuclear medicine and biology

authors： Sun X,Chu T,Wang X

更新日期：2010-02-01 00:00:00

abstract：:The chemical purity and stability of a radio pharmaceutical 99mTc-N-(2,6-diethyl-3-iodo-phenylcarbamoylmethyl)-iminodiacetic acid (IODIDA) has been studied using HPLC. The HPLC results indicate that IODIDA decomposed into at least three species after 99mTc labelling, and the amount of these varied with time. Mass spec...

journal_title：Nuclear medicine and biology

authors： Lundberg PS,Jacobsson L,Stenhagen G,Mårtensson J,Fjälling M

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:This study aimed to assess the striatal [(18)F]FE-PE2I binding and the immunohistochemical stain of tyrosine hydroxylase (TH) in the striatum, and to evaluate the effects of therapeutic drugs on [(18)F]FE-PE2I binding. METHODS:Dynamic PET/CT of [(18)F]FE-PE2I was performed in Parkinson's disease (PD) rat model...

journal_title：Nuclear medicine and biology

authors： Bang JI,Jung IS,Song YS,Park HS,Moon BS,Lee BC,Kim SE

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the biodistribution and localization of an anti-inflammatory nonapeptide coupled to synovial targeting peptide (HAP-1) in rat adjuvant-induced arthritis. PROCEDURE:N(ε)-functionalized histidine derivative was coupled to the N-terminus of core peptide (CP) and HAP-1 to a...

journal_title：Nuclear medicine and biology

authors： Ali M,Vanniasinghe A,Kumar V,Barnett R,Alberto R,Manolios N

更新日期：2011-07-01 00:00:00

abstract：INTRODUCTION:We measured the tiagabine-induced enhancement of the GABAA receptor's affinity for benzodiazepine ligands ("GABA shift") using [18F]flumazenil (FMZ) PET with preclinical application of bolus plus constant infusion (B/I). Differences in quantified results of [18F]FMZ binding were compared to that of [18F]FM...

journal_title：Nuclear medicine and biology

authors： Kim W,Park HS,Moon BS,Lee BC,Kim SE

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Rodent models are extensively used to assess the biochemical and physiological changes associated with aging. They play a major role in the development of therapies for age-related pathologies such as Parkinson's disease. To validate the usefulness of these animal models in aging or age-related disease res...

journal_title：Nuclear medicine and biology

authors： Niñerola-Baizán A,Rojas S,Roé-Vellvé N,Lomeña F,Ros D,Pavía J

更新日期：2015-04-01 00:00:00

abstract：:An in vivo estimation of the newly synthesized MAO-A specific inhibitor, [125I]-labeled N-[3(2,4-dichloro-6-iodophenoxy)propyl]-N-methyl-2- propynylamine ([125I]-iodoclorgyline), was performed. Retention of the radioactivity of this radioligand was observed in the brain from 1 h post-injection. Pretreatments with clor...

journal_title：Nuclear medicine and biology

authors： Hirata M,Magata Y,Ohmomo Y,Saji H,Murakami K,Takagaki T,Yamamura N,Tanaka C,Konishi J,Yokoyama A

更新日期：1995-02-01 00:00:00

abstract：INTRODUCTION:This study investigated radiolabeled bacteriophages for specific detection of infection through gamma imaging. Previously, a (99m)Tc-labeled M13 phage demonstrated specific binding for its host Escherichia coli in vitro and in mice through imaging. METHODS:This study was extended to phages P22, E79, VD-13...

journal_title：Nuclear medicine and biology

authors： Rusckowski M,Gupta S,Liu G,Dou S,Hnatowich DJ

更新日期：2008-05-01 00:00:00

abstract：:Melanin, a natural biological pigment present in many organisms, has been found to exhibit multiple functions. An important property of melanin is its ability to chelate metal ions strongly, which might be developed as an iron chelator for iron overload therapy. Herein, we prepared the ultrasmall water-soluble melanin...

journal_title：Nuclear medicine and biology

authors： Zhang P,Yue Y,Pan D,Yang R,Xu Y,Wang L,Yan J,Li X,Yang M

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:The commercially available 68Ge/68Ga generators are generally used in clinical context in conjunction with automated or semi-automated modules for the syntheses of 68Ga radiopharmaceuticals. It is desirable to develop strategies for the formulation of 68Ga-radiopharmaceuticals without use of such expensive...

journal_title：Nuclear medicine and biology

authors： Chakravarty R,Chakraborty S,Radhakrishnan ER,Kamaleshwaran K,Shinto A,Dash A

更新日期：2017-03-01 00:00:00

abstract：:Error estimates for arteriovenous difference were calculated by two models, a lag time model and a compartmental model, using Tc99m-diethylenetriaminepentaacetic acid (DTPA) plasma clearance curves from 40 subjects and Tc99m-MAG3 (mercaptoacetyltriglycine) curves from 18 subjects. It was found that correcting for the ...

journal_title：Nuclear medicine and biology

authors： Russell CD,Dubovsky EV

更新日期：1999-08-01 00:00:00

abstract：INTRODUCTION:Gonadotropin releasing hormone (GnRH) receptor is overexpressed in many human tumors. Previously we developed a 18F-labelled GnRH peptide. Although the GnRH-targeted PET probe can be clearly visualized by microPET imaging in a PC-3 xenograft model, clinical applications of the probe have been limited by co...

journal_title：Nuclear medicine and biology

authors： Huang S,Wu H,Li B,Fu L,Sun P,Wang M,Hu K

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene in combination with radiolabeled nucleoside substrates is the most widely used reporter system. This study characterized 1-(2'-deoxy-2'-[(18)F]fluoro-β-D-arabinofuranosyl)-5-iodocytosine ((18)F-FIAC) as a new potential positron emission tomography (P...

journal_title：Nuclear medicine and biology

authors： Chan PC,Wu CY,Chang WY,Chang WT,Alauddin M,Liu RS,Lin WJ,Chen FD,Chen CL,Wang HE

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Necrosis is a form of cell death that occurs in a variety of pathological conditions but can also be the result of therapy in cancer treatment. A radiotracer that could image necrotic cell death using PET could therefore be a useful tool to provide relevant information on the disease activity or therapeuti...

journal_title：Nuclear medicine and biology

authors： Prinsen K,Cona MM,Cleynhens BJ,Li J,Vanbilloen H,Dyubankova N,Lescrinier E,Ni Y,Bormans GM,Verbruggen AM

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Radiolabeled gastrin analogs represent attractive candidates for diagnosis and therapy of cholecystokinin subtype-2 receptor (CCK2R)-expressing tumors. Radiolabeled des(Glu)5-gastrins show favorably low renal accumulation, but localize poorly in CCK2R-positive lesions. We introduce herein three truncated [...

journal_title：Nuclear medicine and biology

authors： Kaloudi A,Nock BA,Lymperis E,Sallegger W,Krenning EP,de Jong M,Maina T

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Renal uptake of Tc-99m-MG3 involves organic anion transporter (OAT). Treatment with drugs showing OAT affinity might interfere with renal uptake of Tc-99m-MAG3, leading to misinterpretation in Tc-99m-MAG3. This study was conducted to discuss a possible drug interference with Tc-99m-MAG3 diagnosis on OAT si...

journal_title：Nuclear medicine and biology

authors： Takahara N,Saga T,Inubushi M,Kusuhara H,Seki C,Ito S,Oyama N,Yokoyama O,Sugiyama Y,Fujibayashi Y

更新日期：2013-07-01 00:00:00

abstract：:Porcine insulin was labeled with 99mTc by direct tin reduction. More than 95% labeling efficiency was obtained on paper chromatography in saline and methyl ethyl ketone. The stability of the labeled compound was confirmed by paper chromatography at 3 h post-labeling and by human serum albumin (HSA) challenge. PAGE pat...

journal_title：Nuclear medicine and biology

authors： Awasthi V,Gambhir S,Sewatkar AB

更新日期：1994-02-01 00:00:00

abstract：:Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake ...

journal_title：Nuclear medicine and biology

authors： McCarthy TJ,Dence CS,Holmberg SW,Markham J,Schuster DP,Welch MJ

更新日期：1996-08-01 00:00:00

abstract：:We prepared 5-HT(1A) receptor ligands (S)-N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]-3-[11C]methylthiobenzamide ([11C](S)-PPMMB) (Ki = 4.3 nM) and the less active [(11)C](R)-PPMMB (Ki = 160 nM) by reduction of the disulfide dimer and subsequent [(11)C]methylation of demethyl (S)- and (R)-PPMMB, respectively. Both ra...

journal_title：Nuclear medicine and biology

authors： Fujio M,Nagata S,Kawamura K,Sugiyama N,Tanaka H,Uno K,Ishiwata K

更新日期：2002-08-01 00:00:00

abstract：:Most radioligands are substantially metabolised in peripheral organs during the course of positron emission tomography (PET) recordings. Accurate determination of plasma concentrations of unmetabolised radioligands is often important for quantification of data from PET studies. The fractions of untransformed radioliga...

journal_title：Nuclear medicine and biology

authors： Gillings NM,Bender D,Falborg L,Marthi K,Munk OL,Cumming P

更新日期：2001-01-01 00:00:00

abstract：:111In-LDTPA galactose BSA (bovine serum albumin) was used to evaluate the asialoglycoprotein receptor (ASGPR) system in both normal and ASGPR-deficient mice. The radiolabeled glycoprotein had complete liver uptake in both normal and ASGPR-deficient mice. Metabolism and hepatic cell-type distribution studies were perfo...

journal_title：Nuclear medicine and biology

authors： Deal KA,Cristel ME,Welch MJ

更新日期：1998-05-01 00:00:00

abstract：:We have synthesized three different PET ligands to investigate the physiological function of metabotropic glutamate subtype 5 receptors (mGluR5) in vivo: 2-[(11)C]methyl-6-(2-phenylethynyl)pyridine ([(11)C]MPEP), 2-(2-(3-[(11)C]methoxyphenyl)ethynyl)pyridine ([(11)C]M-MPEP) and 2-(2-(5-[(11)C]methoxypyridin-3-yl)ethyn...

journal_title：Nuclear medicine and biology

authors： Yu M,Tueckmantel W,Wang X,Zhu A,Kozikowski AP,Brownell AL

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:The present article demonstrates a 'mix-and-use' approach for radiolabeling RGD peptide derivative with (68)Ga, which is easily adaptable in hospital radiopharmacy practice. The radiotracer thus formulated was successfully used for positron emission tomography (PET) imaging of breast cancer in human patien...

journal_title：Nuclear medicine and biology

authors： Chakraborty S,Chakravarty R,Vatsa R,Bhusari P,Sarma HD,Shukla J,Mittal BR,Dash A

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Several 11C and 18F labeled 3,4-dihydroxy-l-phenylalanine (l-DOPA) analogues have been used for neurologic and oncologic diseases, especially for brain tumors and neuroendocrine tumors PET imaging. However, 18F-labeled N-substituted l-DOPA analogues have not been reported so far. In the current study, radi...

journal_title：Nuclear medicine and biology

authors： Tang C,Nie D,Tang G,Gao S,Liu S,Wen F,Tang X

更新日期：2017-07-01 00:00:00

abstract：UNLABELLED:The radiolabelled bombesin analogue AMBA shows high potential for diagnosis and treatment of prostate and breast cancer, but the influence of different chelators, which differ in terms of radiochemical reactivity and stability, have not been explored so far. In order to find the best suitable chelator for la...

journal_title：Nuclear medicine and biology

authors： Asti M,Iori M,Capponi PC,Atti G,Rubagotti S,Martin R,Brennauer A,Müller M,Bergmann R,Erba PA,Versari A

更新日期：2014-01-01 00:00:00

abstract：:The anabolism of isotopically labeled amino acids was compared between the cerebrum and the cerebellum in conscious rat at three feeding conditions. After L-[2-18F]fluorophenylalanine and L-[2,6-3H]phenylalanine injections, the incorporation rate of both radioactivity into protein fraction showed no difference between...

journal_title：Nuclear medicine and biology

authors： Nakamichi H,Murakami M,Miura S,Kondoh Y,Mizusawa S,Ono Y

更新日期：1994-10-01 00:00:00

abstract：:The premise that, over the course of Alzheimer's disease (AD), changes in the levels of the vesicular acetylcholine transporter (VAChT) occur in parallel with changes to other cholinergic marker proteins provides the basis for the applicability of benzovesamicol derivatives as radioligands for AD studies by single pho...

journal_title：Nuclear medicine and biology

authors： Emond P,Mavel S,Zea-Ponce Y,Kassiou M,Garreau L,Bodard S,Drossard ML,Chalon S,Guilloteau D

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:The utility of [(18)F]FPBM [2-(2'-((dimethylamino)methyl)-4'-(3-[(18)F]-fluoropropoxy)phenylthio)benzenamine], a selective serotonin transporter (SERT) tracer, and [(18)F]AV-133 [(+)-2-Hydroxy-3-isobutyl-9-(3-fluoropropoxy)-10-methoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine], a selective vesicular m...

journal_title：Nuclear medicine and biology

authors： Wang JL,Oya S,Parhi AK,Lieberman BP,Ploessl K,Hou C,Kung HF

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the effectiveness of PET in differentiating malignant from benign pancreatic cystic tumors. METHODS:Between 2009 and 2010, all patients with pancreatic cystic tumors who had PET, triple phase contrast computed tomography (CT) and endoscopic ultrasound (EUS) were reviewed. Clinicopathological cha...

journal_title：Nuclear medicine and biology

authors： Zhang Y,Frampton AE,Martin JL,Kyriakides C,Bong JJ,Habib NA,Vlavianos P,Jiao LR

更新日期：2012-10-01 00:00:00