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Inhaled [13N]nitric oxide: a positron emission tomography (PET) study.

Abstract：

:Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [13N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.

journal_name

Nucl Med Biol

journal_title

Nuclear medicine and biology

authors

McCarthy TJ,Dence CS,Holmberg SW,Markham J,Schuster DP,Welch MJ

doi

10.1016/0969-8051(96)00072-8

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

773-7

issue

6

eissn

0969-8051

issn

1872-9614

pii

0969-8051(96)00072-8

journal_volume

23

pub_type

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