Decreased kidney uptake of technetium-99m-labelled Fab' fragments in ovarian carcinoma bearing nude mice using a cleavable chelator.

abstract：INTRODUCTION:Several psychiatric and neurodegenerative diseases are associated with malfunction of brain norepinephrine transporter (NET). However, current clinical evaluations of NET function are limited by the lack of sufficiently sensitive methods of detection. To this end, we have synthesized exo-3-[(6-[18F]fluoro-...

journal_title：Nuclear medicine and biology

authors： Kirjavainen AK,Forsback S,López-Picón FR,Marjamäki P,Takkinen J,Haaparanta-Solin M,Peters D,Solin O

更新日期：2018-01-01 00:00:00

abstract：:The in vivo brain regional distribution of 2-[18F]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followed the regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in vivo was demonstrated by inhibition with nAC...

journal_title：Nuclear medicine and biology

authors： Horti AG,Scheffel U,Koren AO,Ravert HT,Mathews WB,Musachio JL,Finley PA,London ED,Dannals RF

更新日期：1998-10-01 00:00:00

abstract：:Brofaromine (4-5(-methoxy-7-bromobenzofuranyl)-2-piperidine-HCl) is a potent and selective inhibitor of monoamine oxidase (MAO) A. Two methods for its synthesis and a preliminary positron emission tomography (PET) evaluation in monkey brain are described. The first method, at low carrier concentration of CO2, consiste...

journal_title：Nuclear medicine and biology

authors： Ametamey SM,Beer HF,Guenther I,Antonini A,Leenders KL,Waldmeier PC,Schubiger PA

更新日期：1996-04-01 00:00:00

abstract：:The ability to measure blood flow to tumors non-invasively may be of importance in monitoring tumor therapies, assessing drug delivery, and understanding tumor physiology. Of all the radiotracer methods that have been proposed to measure tumor blood flow, the method based on labeled water-H(2)(15)O-may be the most app...

journal_title：Nuclear medicine and biology

authors： Bacharach SL,Libutti SK,Carrasquillo JA

更新日期：2000-10-01 00:00:00

abstract：:The diagnostic potential of PET using the amino acid analogue O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) in brain tumor diagnostics has been proven in many studies during the last two decades and is still the subject of multiple studies every year. In addition to standard magnetic resonance imaging (MRI), positron e...

journal_title：Nuclear medicine and biology

authors： Stegmayr C,Stoffels G,Filß C,Heinzel A,Lohmann P,Willuweit A,Ermert J,Coenen HH,Mottaghy FM,Galldiks N,Langen KJ

更新日期：2020-02-19 00:00:00

abstract：INTRODUCTION:The present article demonstrates a 'mix-and-use' approach for radiolabeling RGD peptide derivative with (68)Ga, which is easily adaptable in hospital radiopharmacy practice. The radiotracer thus formulated was successfully used for positron emission tomography (PET) imaging of breast cancer in human patien...

journal_title：Nuclear medicine and biology

authors： Chakraborty S,Chakravarty R,Vatsa R,Bhusari P,Sarma HD,Shukla J,Mittal BR,Dash A

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid (anti-[(18)F]FACBC) is a positron emission tomography (PET) tracer used to visualize prostate cancer (PCa). In this study, we investigated the differences in anti-[(18)F]FACBC accumulation between metastatic and inflamed lymph node (LN) lesions. METH...

journal_title：Nuclear medicine and biology

authors： Kanagawa M,Doi Y,Oka S,Kobayashi R,Nakata N,Toyama M,Shirakami Y

更新日期：2014-08-01 00:00:00

abstract：:Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sen...

journal_title：Nuclear medicine and biology

authors： Liu Z,Stevenson GD,Barrett HH,Kastis GA,Bettan M,Furenlid LR,Wilson DW,Woolfenden JM

更新日期：2004-01-01 00:00:00

abstract：:In this study, the (+)-enantiomer of radioiodinated 2-[4-(4-iodophenyl)piperidino]cyclohexanol [(+)-[(125)I]-p-iodovesamicol] [(+)-[(125)I]pIV], which is reported to bind with high affinity to sigma-1 receptors in vitro, was tested for its usefulness in imaging sigma-1 receptors in the central nervous system (CNS) in ...

journal_title：Nuclear medicine and biology

authors： Akhter N,Shiba K,Ogawa K,Kinuya S,Nakajima K,Mori H

更新日期：2007-08-01 00:00:00

abstract：:A new tetrahydrazido-germanium (GeTH) ligand was synthesized, characterized and complexed with 99mTc. The negatively charged 99mTc-chelate was shown to form in high yields at neutral pH in the absence of other reducing agents and exhibits high in vitro and in vivo stability. ...

journal_title：Nuclear medicine and biology

authors： Singh PR,Katti KK,Katti KV,Corlija M,Ketring AR,Volkert WA,Holmes RR

更新日期：1994-11-01 00:00:00

abstract：INTRODUCTION:Gonadotropin releasing hormone (GnRH) receptor is overexpressed in many human tumors. Previously we developed a 18F-labelled GnRH peptide. Although the GnRH-targeted PET probe can be clearly visualized by microPET imaging in a PC-3 xenograft model, clinical applications of the probe have been limited by co...

journal_title：Nuclear medicine and biology

authors： Huang S,Wu H,Li B,Fu L,Sun P,Wang M,Hu K

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Telmisartan, a nonpeptide angiotensin II AT1 receptor antagonist used as an antihypertensive drug, is specifically taken up by the liver through the OATP1B3. PET imaging with [(11)C]telmisartan is expected to provide information about the whole body pharmacokinetics of telmisartan as well as its transport ...

journal_title：Nuclear medicine and biology

authors： Shimizu K,Takashima T,Yamane T,Sasaki M,Kageyama H,Hashizume Y,Maeda K,Sugiyama Y,Watanabe Y,Senda M

更新日期：2012-08-01 00:00:00

abstract：:We investigated sigma(1) and dopamine D(2) receptor occupancy in mouse brain after a single injection of haloperidol, nemonapride, or spiperone using [(11)C]SA4503 and [(11)C]raclopride, respectively. Co-injection of the three compounds significantly blocked the uptake of each radioligand. Six hours later, only halope...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Kawamura K,Kobayashi T,Matsuno K

更新日期：2003-05-01 00:00:00

abstract：:With [11C]raclopride,[11C]nemonapride and [11C]N-methylspiperone, degeneration of dopamine D2-like receptors in the unilaterally quinolinic acid-lesioned rats was evaluated by positron emission tomography (PET) and ex vivo and in vitro autoradiography. PET showed a decreased uptake of [11C]raclopride in the lesioned s...

journal_title：Nuclear medicine and biology

authors： Ishiwata K,Ogi N,Hayakawa N,Umegaki H,Nagaoka T,Oda K,Toyama H,Endo K,Tanaka A,Senda M

更新日期：2002-04-01 00:00:00

abstract：:Porcine insulin was labeled with 99mTc by direct tin reduction. More than 95% labeling efficiency was obtained on paper chromatography in saline and methyl ethyl ketone. The stability of the labeled compound was confirmed by paper chromatography at 3 h post-labeling and by human serum albumin (HSA) challenge. PAGE pat...

journal_title：Nuclear medicine and biology

authors： Awasthi V,Gambhir S,Sewatkar AB

更新日期：1994-02-01 00:00:00

abstract：:Central benzodiazepine receptor binding was studied in spontaneously epileptic rats (SER) and in their parent strain. Kyoto-Wistar (KW) rats, by ex vivo quantitative autoradiography with [125I]iomazenil. Thirteen-week-old SER developed tonic and absence-like seizures following mild stimulation by tapping at 5 min befo...

journal_title：Nuclear medicine and biology

authors： Nagata T,Saji H,Nishizawa S,Yonekura Y,Yamamoto I,Iida Y,Magata Y,Konishi J,Serikawa T,Yokoyama A

更新日期：1995-05-01 00:00:00

abstract：:Synthesis and preliminary biological evaluation of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl)-guanine ([18F]FHBG) is reported. 9-(4-Hydroxy-3-hydroxymethylbutyl)-guanine (penciclovir) 4 was converted to 9-[N2, O-bis-(methoxytrityl)-3-(tosylmethybutyl)]guanine 7 by treatment with methoxytrityl chloride followed by tosylat...

journal_title：Nuclear medicine and biology

authors： Alauddin MM,Conti PS

更新日期：1998-04-01 00:00:00

abstract：:A consensus has emerged that early imaging (within 20 min post-injection [p.i.] of sestamibi) has the highest diagnostic yield. Tc-99m-sestamibi uptake has been associated with P-glycoprotein-mediated multi-drug resistance (MDR), tumor vascularization, invasiveness, and cell proliferation. The aim of this study was to...

journal_title：Nuclear medicine and biology

authors： Leitha T,Glaser C,Lang S

更新日期：1998-08-01 00:00:00

abstract：INTRODUCTION:Histone deacetylases (HDACs) are enzymes involved in epigenetic modifications that shift the balance toward chromatin condensation and silencing of gene expression. Here, we evaluate the utility of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide ([(18)F]FAHA) for positron emission tomography imaging of HDAC a...

journal_title：Nuclear medicine and biology

authors： Reid AE,Hooker J,Shumay E,Logan J,Shea C,Kim SW,Collins S,Xu Y,Volkow N,Fowler JS

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Detection of vulnerable plaques is critically important for the selection of appropriate treatment and/or the prevention of atherosclerosis and ensuing cardiovascular diseases. In order to clarify the utility of [11C]acetate for atherosclerosis imaging, we determined the uptake and metabolism of acetate by...

journal_title：Nuclear medicine and biology

authors： Yamasaki K,Yamashita A,Zhao Y,Shimizu Y,Nishii R,Kawai K,Tamaki N,Zhao S,Asada Y,Kuge Y

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Positron emission tomography (PET) is extensively used in clinical oncology for tumor detection. This study aimed to explore the application of the radiotracers [18F]fluorodeoxyglucose ([18F]FDG), 3'-deoxy-3'- [18F]fluorothymidine ([18F]FLT), and [18F]fluoromisonidazole ([18F]FMISO) in the diagnosis and mo...

journal_title：Nuclear medicine and biology

authors： Jiang H,Zhang R,Jiang H,Zhang M,Guo W,Feng G,Pan W,Xu H,Wang S

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:The cellular binding and processing of an epidermal growth factor receptor (EGFR) targeting affibody molecule, (Z(EGFR:955))(2), was studied. This new and small molecule is aimed for applications in nuclear medicine. The natural ligand epidermal growth factor (EGF) and the antibody cetuximab were studied f...

journal_title：Nuclear medicine and biology

authors： Nordberg E,Friedman M,Göstring L,Adams GP,Brismar H,Nilsson FY,Ståhl S,Glimelius B,Carlsson J

更新日期：2007-08-01 00:00:00

abstract：:NCQ 115 ((+)-(R)-5-bromo-N-((1-(4-fluorobenzyl)-2-pyrrolidinyl)methyl)-2, 3-dimethoxybenzamide) is a selective dopamine D-2 receptor antagonist. NCQ 115 has a fluorine in a synthetically suitable position in the parent compound and was therefore suggested as a potential 18F-labelled radioligand for positron emission t...

journal_title：Nuclear medicine and biology

authors： Halldin C,Högberg T,Farde L

更新日期：1994-05-01 00:00:00

abstract：INTRODUCTION:HDAC6, a structural and functional distinct member of the HDAC-family, shows great promise as a target to treat several cancers and neurodegenerative diseases. Several clinical trials are evaluating HDAC6 inhibitors in solid tumours and haematological malignancies, but so far no HDAC6 inhibitor has receive...

journal_title：Nuclear medicine and biology

authors： Vermeulen K,Ahamed M,Luyten K,Bormans G

更新日期：2019-01-01 00:00:00

abstract：:Three 3-pyridyl ether nicotinic ligands-(S)-5-Iodo-3-[(2-pyrrolidinyl)-methoxy]pyridine (5-iodo-A-85865), (S)-5-Iodo-3-[1-(methyl)-2-pyrrolidinyl-methoxy]pyridine (5-Iodo-A-84543), and (S)-5-iodo-3-[1-methyl-(2-azetidinyl)-methoxy]pyridine (5-iodo-N-Me-A-85380) were labeled with I-125/I-123, and their ability to label...

journal_title：Nuclear medicine and biology

authors： Fan H,Scheffel UA,Rauseo P,Xiao Y,Dogan AS,Yokoi F,Hilton J,Kellar KJ,Wong DF,Musachio JL

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:Serotonin transporters (SERT) play an important role in controlling serotonin concentration in the synaptic cleft and in managing postsynaptic signal transduction. Inhibitors of SERT binding are well known as selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, sertraline, paroxetine, and esci...

journal_title：Nuclear medicine and biology

authors： Zhang Y,Liu F,Xiao H,Yao X,Li G,Choi SR,Ploessl K,Zha Z,Zhu L,Kung HF

更新日期：2018-11-01 00:00:00

abstract：:188Re-perrhenate has been reported effective in preventing restenosis after percutaneous transluminal coronary angioplasty. However, if the balloon ruptures, 188Re-perrhenate is released into the circulation, causing high radiation dosing to the thyroid and stomach. In this study, we evaluated the effects of perchlora...

journal_title：Nuclear medicine and biology

authors： Lin WY,Hsieh JF,Tsai SC,Yen TC,Wang SJ,Knapp FF Jr

更新日期：2000-01-01 00:00:00

abstract：:Melanin, a natural biological pigment present in many organisms, has been found to exhibit multiple functions. An important property of melanin is its ability to chelate metal ions strongly, which might be developed as an iron chelator for iron overload therapy. Herein, we prepared the ultrasmall water-soluble melanin...

journal_title：Nuclear medicine and biology

authors： Zhang P,Yue Y,Pan D,Yang R,Xu Y,Wang L,Yan J,Li X,Yang M

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:In previous in-vitro and ex-vivo studies we proved the specific uptake of (99m)Tc radiolabeled chondroitin sulfate (CS) in human articular cartilage. As a logical next step for the clinical use for imaging osteoarthritis we investigated in-vivo uptake of (99m)TcCS in dogs. PROCEDURES:The radiolabeling of CS Co...

journal_title：Nuclear medicine and biology

authors： Sobal G,Velusamy K,Kosik S,Menzel J,Hacker M,Pagitz M

更新日期：2016-06-01 00:00:00

abstract：:The pituitary gonadotropins FSH and LH are secreted into blood as dimeric glycoproteins which display a wide heterogeneity when submitted to technique of separation based on electric charge. That supports the assumption of a major role of the carbohydrates moieties as a source of heterogeneity. No clear difference how...

journal_title：Nuclear medicine and biology

authors： Roger M,Lalhou N

更新日期：1994-04-01 00:00:00