11C-5-hydroxytryptophan positron emission tomography after radiofrequency ablation of neuroendocrine tumor liver metastases.

abstract：:An ultrafast and efficient high-performance liquid chromatographic (LC) method was developed to purify positron emission tomography (PET) radiopharmaceuticals as well as for metabolite analysis of the plasma sample. Chromatographic separation was achieved on a short (60 mm length) semipreparative (10 mm I.D.) column p...

journal_title：Nuclear medicine and biology

authors： Nakao R,Ito T,Hayashi K,Fukumura T,Suzuki K

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Prognostic markers for progression of polycystic kidney disease (PKD) are limited. We evaluated the potential of early para-[(18)F]fluorohippurate ([(18)F]PFH) positron emission tomography (PET) renography to predict future progression of PKD in Han:SPRD rats with slowly progressive autosomal dominant PKD....

journal_title：Nuclear medicine and biology

authors： Pathuri G,Hedrick AF,Awasthi V,Cowley BD Jr,Gali H

更新日期：2016-01-01 00:00:00

abstract：:Pharmacokinetic computer simulations reveal a discrepancy between the in vivo and in vitro neuroreceptor subtype selectivity of radioligands. For radioligands with an in vitro neuroreceptor subtype selectivity between 0.1 and 10.0, the in vivo neuroreceptor subtype selectivity appears to be constrained to be between 0...

journal_title：Nuclear medicine and biology

authors： Zeeberg BR

更新日期：1999-10-01 00:00:00

abstract：INTRODUCTION:To determine the availability of nicotinic acetylcholine receptors in different human brain regions using the positron emission tomography (PET) radioligand 2-[18F]fluoro-A-85380 (2-[18F]FA) and invasive approaches for quantification, it is important to correct the arterial input function as well for plasm...

journal_title：Nuclear medicine and biology

authors： Sorger D,Becker GA,Hauber K,Schildan A,Patt M,Birkenmeier G,Otto A,Meyer P,Kluge M,Schliebs R,Sabri O

更新日期：2006-10-01 00:00:00

abstract：:The anabolism of isotopically labeled amino acids was compared between the cerebrum and the cerebellum in conscious rat at three feeding conditions. After L-[2-18F]fluorophenylalanine and L-[2,6-3H]phenylalanine injections, the incorporation rate of both radioactivity into protein fraction showed no difference between...

journal_title：Nuclear medicine and biology

authors： Nakamichi H,Murakami M,Miura S,Kondoh Y,Mizusawa S,Ono Y

更新日期：1994-10-01 00:00:00

abstract：INTRODUCTION:Noninvasive imaging of small animals to measure biodistributions and pharmacokinetics of radiolabeled agents is increasingly seen as an effective alternative to external counting of tissues obtained by sacrifice and dissection. However, we have observed important disagreements in measuring the accumulation...

journal_title：Nuclear medicine and biology

authors： Cheng D,Rusckowski M,Pretorius PH,Chen L,Xiao N,Liu Y,Liu G,Liang M,Liu X,Dou S,Hnatowich DJ

更新日期：2011-08-01 00:00:00

abstract：:9-[(3-[18F]Fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG, 2) has been synthesized by nucleophilic substitution of N(2)-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-toluenesulfonyloxy-2-propoxy]methyl]guanine (1) with potassium [18F]fluoride/Kryptofix 2.2.2 followed by deprotection with 1 N HCl and...

journal_title：Nuclear medicine and biology

authors： Shiue GG,Shiue CY,Lee RL,MacDonald D,Hustinx R,Eck SL,Alavi AA

更新日期：2001-10-01 00:00:00

abstract：:The herpes simplex virus type 1 thymidine kinase (HSV1-TK) reporter system is being used to directly and indirectly monitor therapeutic gene expression, immune cell trafficking and protein-protein interactions in various living animals. However, the issues of HSV1-TK enzyme stability in living cells and whether this r...

journal_title：Nuclear medicine and biology

authors： Hsieh CH,Liu RS,Wang HE,Hwang JJ,Deng WP,Chen JC,Chen FD

更新日期：2006-07-01 00:00:00

abstract：INTRODUCTION:Detection of vulnerable plaques is critically important for the selection of appropriate treatment and/or the prevention of atherosclerosis and ensuing cardiovascular diseases. In order to clarify the utility of [11C]acetate for atherosclerosis imaging, we determined the uptake and metabolism of acetate by...

journal_title：Nuclear medicine and biology

authors： Yamasaki K,Yamashita A,Zhao Y,Shimizu Y,Nishii R,Kawai K,Tamaki N,Zhao S,Asada Y,Kuge Y

更新日期：2018-01-01 00:00:00

abstract：:A new 99mTc labelling method using a cleavable chelator, RP-1, was developed. In this study Balb/c mice with ovarian carcinoma xenografts received various Fab' fragments labelled with 99mTc either directly or via RP-1. Kidney uptake was significantly lower for the RP-1 linked conjugates. Tumour uptake showed no signif...

journal_title：Nuclear medicine and biology

authors： Tibben JG,Massuger LF,Boerman OC,Claessens RA,Borm GF,Pak KY,Koenders EB,Corstens FH

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:Radiopharmaceuticals that can bind selectively the kappa-opioid receptor may present opportunities for staging clinical brain disorders and evaluating the efficiency of new therapies related to stroke, neurodegenerative diseases or opiate addiction. The N-methylated derivative of JDTic (named MeJDTic), whi...

journal_title：Nuclear medicine and biology

authors： Poisnel G,Oueslati F,Dhilly M,Delamare J,Perrio C,Debruyne D,Barré L

更新日期：2008-07-01 00:00:00

abstract：:The gastrin releasing peptide (GRP) receptor is becoming an increasingly attractive target for development of new radiolabeled peptides with diagnostic and therapeutic potential. The attractiveness of the GRP receptor as a target is based upon the functional expression of GRP receptors in several tumors of neuroendocr...

journal_title：Nuclear medicine and biology

authors： Smith CJ,Volkert WA,Hoffman TJ

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:In previous in-vitro and ex-vivo studies we proved the specific uptake of (99m)Tc radiolabeled chondroitin sulfate (CS) in human articular cartilage. As a logical next step for the clinical use for imaging osteoarthritis we investigated in-vivo uptake of (99m)TcCS in dogs. PROCEDURES:The radiolabeling of CS Co...

journal_title：Nuclear medicine and biology

authors： Sobal G,Velusamy K,Kosik S,Menzel J,Hacker M,Pagitz M

更新日期：2016-06-01 00:00:00

abstract：:The discovery of neuroendocrine differentiation in hormone-refractory prostatic adenocarcinoma has opened a potentially new therapeutic approach in this group of patients with a poor prognosis and few effective therapy modalities. Based on previous findings of increased uptake of 11C-5-hydroxytryptophan (11C-5-HTP) in...

journal_title：Nuclear medicine and biology

authors： Kälkner KM,Ginman C,Nilsson S,Bergström M,Antoni G,Ahlström H,Långström B,Westlin JE

更新日期：1997-05-01 00:00:00

abstract：:A positron-emitter labeled radioligand for the glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor, [(11)C]L-703,717, was examined for its ability to penetrate the brain in animals by simultaneous use with drugs having high-affinity separate binding sites on human serum albumin. [(11)C]L-703,717 has poor ...

journal_title：Nuclear medicine and biology

authors： Haradahira T,Zhang M,Maeda J,Okauchi T,Kawabe K,Kida T,Suzuki K,Suhara1 T

更新日期：2000-05-01 00:00:00

abstract：INTRODUCTION:Bromodomain and extra-terminal domain (BET) family proteins play a vital role in the epigenetic regulation process by interacting with acetylated lysine (Ac-K) residues in histones. BET inhibitors have become promising candidates to treat various diseases through the inhibition of the interaction between B...

journal_title：Nuclear medicine and biology

authors： Bai P,Lu X,Lan Y,Chen Z,Patnaik D,Fiedler S,Striar R,Haggarty SJ,Wang C

更新日期：2020-01-01 00:00:00

abstract：:The in vivo brain regional distribution of 2-[18F]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followed the regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in vivo was demonstrated by inhibition with nAC...

journal_title：Nuclear medicine and biology

authors： Horti AG,Scheffel U,Koren AO,Ravert HT,Mathews WB,Musachio JL,Finley PA,London ED,Dannals RF

更新日期：1998-10-01 00:00:00

abstract：:A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation peri...

journal_title：Nuclear medicine and biology

authors： Zalutsky MR,Stabin MG,Larsen RH,Bigner DD

更新日期：1997-04-01 00:00:00

abstract：:A new tetrahydrazido-germanium (GeTH) ligand was synthesized, characterized and complexed with 99mTc. The negatively charged 99mTc-chelate was shown to form in high yields at neutral pH in the absence of other reducing agents and exhibits high in vitro and in vivo stability. ...

journal_title：Nuclear medicine and biology

authors： Singh PR,Katti KK,Katti KV,Corlija M,Ketring AR,Volkert WA,Holmes RR

更新日期：1994-11-01 00:00:00

abstract：UNLABELLED:The purpose of this study is to reveal characteristics of (64)Cu-labeled diacetyl-bis(N(4)-methylthiosemicarbazone) ([(64)Cu]Cu-ATSM) during cell proliferation and hypoxia by autoradiography imaging and immunohistochemical staining. METHODS:The intratumoral distributions of [(64)Cu]Cu-ATSM and [(18)F]-2-flu...

journal_title：Nuclear medicine and biology

authors： Oh M,Tanaka T,Kobayashi M,Furukawa T,Mori T,Kudo T,Fujieda S,Fujibayashi Y

更新日期：2009-05-01 00:00:00

abstract：:In this study, we present the evaluation of two new ternary ligand (99m)Tc complexes [(99m)Tc(HYNIC tetramer)(tricine)(L)] [L=isonicotinic acid (ISONIC) and 2,5-pyridinedicarboxylic acid (PDA)] as potential radiotracers for tumor imaging. Athymic nude mice bearing MDA-MB-435 human breast cancer xenografts were used to...

journal_title：Nuclear medicine and biology

authors： Liu S,Kim YS,Hsieh WY,Gupta Sreerama S

更新日期：2008-01-01 00:00:00

abstract：:A comprehensive evaluation of the reactivity of 18F electrophilic fluorinating agents derived from the 18O(p,n)18F reaction conducted in target bodies made of aluminum, silver, copper, nickel, and gold-plated copper is reported. Two representative electrophilic reactions, namely addition across a double bond and subst...

journal_title：Nuclear medicine and biology

authors： Bishop A,Satyamurthy N,Bida G,Barrio JR

更新日期：1996-07-01 00:00:00

abstract：:The pituitary gonadotropins FSH and LH are secreted into blood as dimeric glycoproteins which display a wide heterogeneity when submitted to technique of separation based on electric charge. That supports the assumption of a major role of the carbohydrates moieties as a source of heterogeneity. No clear difference how...

journal_title：Nuclear medicine and biology

authors： Roger M,Lalhou N

更新日期：1994-04-01 00:00:00

abstract：:The synthetic porphyrins, N-benzyl-5,10,15,20-tetrakis (4-carboxyphenyl) porphine (N-bzHTCPP) and N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl) porphine (N-bzHCS3P), represent excellent radiocopper chelating agents that may find utility in antibody-mediated diagnosis and/or therapy. N-bzHCS3P was co...

journal_title：Nuclear medicine and biology

authors： Bhalgat MK,Roberts JC,Mercer-Smith JA,Knotts BD,Vessella RL,Lavallee DK

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:(99m)Tc-MDP (technetium-99(m)-labeled methylene diphosphonate) has been widely used as a radiopharmaceutical for bone scintigraphy in cases of metastatic bone disease. (177)Lu is presently considered as an excellent radionuclide for developing bone pain palliation agents. No study on preparing a complex of (1...

journal_title：Nuclear medicine and biology

authors： Abbasi IA

更新日期：2011-04-01 00:00:00

abstract：:Holmium-166 ferric hydroxide macroaggregate (Ho-166 FHMA) particles possess two important properties for radiosynovectomy; relatively short half-life of the radioisotope and appropriate carrier size. Both these minimize radioactive leakage from the treated joint. This study was conducted to assess the effects of Ho-16...

journal_title：Nuclear medicine and biology

authors： Mäkelä O,Penttilä P,Kolehmainen E,Sukura A,Sankari S,Tulamo RM

更新日期：2002-07-01 00:00:00

abstract：:The application of radionuclide-labeled biomolecules such as monoclonal antibodies or antibody fragments for imaging purposes is called immunoscintigraphy. More specifically, when the nuclides used are positron emitters, such as zirconium-89, the technique is referred to as immuno-PET. Currently, there is an urgent ne...

journal_title：Nuclear medicine and biology

authors： Radchenko V,Bouziotis P,Tsotakos T,Paravatou-Petsotas M,la Fuente Ad,Loudos G,Harris AL,Xanthopoulos S,Filosofov D,Hauser H,Eisenhut M,Ponsard B,Roesch F

更新日期：2016-05-01 00:00:00

abstract：:An iodinated analog of PK11195, 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide , a specific antagonist of the peripheral-type benzodiazepine receptor (omega 3), has been synthesized in three steps with an overall chemical yield of 40%. Both [123I]- and [125I]-Iodo-PK11195 have been synthesize...

journal_title：Nuclear medicine and biology

authors： Gildersleeve DL,Van Dort ME,Johnson JW,Sherman PS,Wieland DM

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:Necrosis is a form of cell death that occurs in a variety of pathological conditions but can also be the result of therapy in cancer treatment. A radiotracer that could image necrotic cell death using PET could therefore be a useful tool to provide relevant information on the disease activity or therapeuti...

journal_title：Nuclear medicine and biology

authors： Prinsen K,Cona MM,Cleynhens BJ,Li J,Vanbilloen H,Dyubankova N,Lescrinier E,Ni Y,Bormans GM,Verbruggen AM

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:Telmisartan, a nonpeptide angiotensin II AT1 receptor antagonist used as an antihypertensive drug, is specifically taken up by the liver through the OATP1B3. PET imaging with [(11)C]telmisartan is expected to provide information about the whole body pharmacokinetics of telmisartan as well as its transport ...

journal_title：Nuclear medicine and biology

authors： Shimizu K,Takashima T,Yamane T,Sasaki M,Kageyama H,Hashizume Y,Maeda K,Sugiyama Y,Watanabe Y,Senda M

更新日期：2012-08-01 00:00:00